miR-141 appears to interrupt tumor spread, a finding that may lead to development of new prostate cancer therapies
BUFFALO, N.Y. — Metastasis, or spread of a tumor from the site of origin to additional organs, causes >90% of cancer-related deaths, but our understanding of the molecular mechanisms behind metastasis remains limited. A research team led by Dean Tang, PhD, Chair of the Department of Pharmacology and Therapeutics at Roswell Park Comprehensive Cancer Center, examined the multistep process that leads to metastasis and their work, which illuminates the role of prostate cancer stem cells that promote tumor growth and metastasis, has been published online ahead of print in the journal Nature Communications.
MicroRNAs (miRNAs) are small genetic molecules that play an essential role in regulating many aspects of cancer cell behavior. When they performed a screening of the miRNA library, Dr. Tang and colleagues found that, surprisingly, only a few miRNAs are commonly deficient or not expressed in prostate cancer stem cells.
The team found that one specific miRNA molecule, miR-141, not only inhibited tumor growth but significantly retarded cancer metastasis in several preclinical prostate cancer models. Taken together with the findings from previous studies reporting the molecule’s powerful tumor-suppression capability, the current study demonstrates the potential of miR-141 as an inhibitor of prostate cancer cell invasion and metastasis, and suggests that synthetic miR-141 may be developed as a “replacement” therapeutic to target prostate cancer metastasis.
“This study represents the most comprehensive investigation to date of the role of the miR-141 molecule in regulating prostate cancer stem cells and their role in metastasis,” says Dr. Tang, senior author of the new study. “These preliminary findings suggest that miR-141 may suppress the metastatic cascade at an early stage and that the overexpression of miR-141 in prostate cancer cells results in less metastasis. Our observations provide a rationale for developing these targeted miRNA molecules into novel antitumor and antimetastasis replacement therapies.”
This research was supported, in part, by grants from the National Cancer Institute (project no. R01CA155693 and P30CA0016056), Department of Defense (award nos. W81XWH-13-1-0352, W81XWH-14-1-0575 and W81XWH-16-1-0575), the Cancer Prevention Research Institute of Texas, MD Anderson Cancer Center and Roswell Park Comprehensive Cancer Center.
The study, “MicroRNA-141 Suppresses Prostate Cancer Stem Cells and Metastasis by Targeting a Cohort of Pro-Metastasis Genes,” is available at nature.com.
The mission of Roswell Park Comprehensive Cancer Center is to understand, prevent and cure cancer. Founded in 1898, Roswell Park is one of the first cancer centers in the country to be named a National Cancer Institute-designated comprehensive cancer center and remains the only facility with this designation in Upstate New York. The Institute is a member of the prestigious National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers; maintains affiliate sites; and is a partner in national and international collaborative programs. For more information, visit www.roswellpark.org, call 1-800-ROSWELL (1-800-767-9355) or email AskRoswell@Roswellpark.org. Follow Roswell Park on Facebook and Twitter.
Deborah Pettibone, Public Information Specialist