Clinical Trials

Clinical Trials

  Section Menu

CIMAvax Vaccine

Roswell Park has launched the first clinical trial in the U.S. to study the CIMAvax-EGF ® vaccine, a lung cancer treatment. Learn more about CIMAvax.

A clinical trial is a study designed to evaluate a promising new medical treatment. It includes research done to evaluate new ways to prevent and diagnose and/or treat cancer. At Roswell Park, up to 50% of our patients are eligible to enter clinical trials. Many types of treatment can be tested including:

  • New ways of preventing cancer such as drugs, diet, and/or exercise
  • New drugs to treat cancer
  • New ways to use existing treatment such as surgery or radiation therapy

When clinical trials identify new and effective treatments, these treatments will eventually become the new standard of care that will be offered to future patients. Today’s standard treatments were researched and proven by clinical trials done in the past.

Should I participate in a clinical trial? (Learn more about clinical trials from the NCI.)

Recently Opened Clinical Trials

A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors
Principal Investigator:
Opyrchal, Mateusz
(M15-654) A Phase 1/2, Multicenter, Dose-Escalation and Expansion Study of Combination Therapy with Venetoclax, Daratumumab and Dexamethasone (With and Without Bortezomib) in Subjects with Relapsed or Refractory Multiple Myeloma
Principal Investigator:
Torka, Pallawi
Matched Targeted Therapy (MTT) Recommendation for Patients with Recurrent, Refractory, or High Risk Leukemias and Myelodysplastic Syndrome
Principal Investigator:
Barth, Matthew J
Comparing Unilateral and Bilateral Deep Inferior Epigastric Perforators (DIEP) Flaps for unilateral breast reconstruction
Principal Investigator:
Moon, Wong K
(ADCT-301-103) A Phase 1b, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of Camidanlumab Tesirine (ADCT-301) in Patients With Selected Advanced Solid Tumors
Principal Investigator:
Puzanov, Igor
(TRPH-222-100) Phase 1, Multicenter, Open-Label Study of the Antibody-Drug Conjugate TRPH-222 in Subjects with Relapsed and/or Refractory B Cell Lymphoma
Principal Investigator:
Hernandez-Ilizaliturri, Francisco J
A Phase 1, First-in-Human, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors with a Specific KRAS Mutation (AMG 510 20170543).
Principal Investigator:
Dy, Grace K
Health Promotion in African American Survivors: Pilot Implementation Research (National Witness Project® Witness Role Models Use Precision Nutrition)
Principal Investigator:
Devonish, Julia A
A Randomized, Multi-Center Phase 2 Trial with a Phase 1 Safety Run-in: Porfimer Sodium Mediated Interstitial Photodynamic Therapy and Standard of Care (SoC) Therapy versus SoC Therapy Alone for the Treatment of Patients with Locally Advanced or...
Principal Investigator:
Arshad, Hassan
Enhancing a home-based walking intervention among breast cancer survivors with rTMS: Feasibility and limited efficacy testing
Principal Investigator:
Sheffer, Christine E
Clinical Observational Study of IMLYGIC use in routine Melanoma treatment in the US (COSMUS 2)
Principal Investigator:
Nanni, Michele
(GO39942) A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL COMPARING THE EFFICACY AND SAFETY OF POLATUZUMAB VEDOTIN IN COMBINATION WITH RITUXIMAB AND CHP (R-CHP) VERSUS RITUXIMAB AND CHOP (R-CHOP) IN PREVIOUSLY UNTREATED...
Principal Investigator:
Hernandez-Ilizaliturri, Francisco J
Impact of a National Comprehensive Cancer Network Compliant Multidisciplinary Consortium on Treatment Decisions in Patients with Localized Prostate Cancer
Principal Investigator:
Guru, Khurshid
Pilot Open Label Clinical Trial Evaluating the Safety and Efficacy of Chemokine Modulation to Enhance the Effectiveness of Pembrolizumab in Patients with Metastatic Triple Negative Breast Cancer
Principal Investigator:
Opyrchal, Mateusz
The Impact of Financial Distress on Prostate Cancer Treatment: A Feasibility Study
Principal Investigator:
Sumlin, Adam B
A Phase 1b/2 Study of PCM-075 in Combination with either Low-Dose Cytarabine or Decitabine in Subjects with Acute Myeloid Leukemia (AML)
Principal Investigator:
Wang, Eunice S
A novel parenting skills intervention to improve medication adherence in pediatric cancer
Principal Investigator:
Bouchard, Elizabeth G
(EA2165) A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer
Principal Investigator:
Boland, Patrick M