Functions and regulation of deubiquitinating enzymes (USPs); Epigenetics; Regulation of gene expression, Molecular mechanism of cancer metastasis.
Heat-shock proteins and cell survival, mitochondrial fragmentation and caspase activation, apoptosis signaling in cancer stem cells.
Tumor suppressor protein p53/transcriptional regulation/genomic damage, DNA repair, and cell cycle control/interaction between p53 and estrogen receptor signaling pathways.
Host- and tumor-mediated mechanisms of antiangiogenic drug resistance and their role in metastatic disease progression.
Research focuses on molecular dissection of various epigenetic mechanisms and understanding their roles in tumor progression and metastasis, with the goal of identifying novel therapeutic, diagnostic and prognostic modalities.
Exploring the noncoding genome and GPCR signaling networks driving pancreas and breast cancer pathogenesis; 3D modeling of human tumors for therapeutic and mechanistic studies.
Research is focused on inhibiting the androgen metabolism enzymes that facilitate prostate cancer therapeutic resistance and prostate cancer recurrence.
Prostate cancer; transgenic mouse models; prostate cancer/bone interaction; preclinical testing of novel therapeutic approaches for prevention and treatment of prostate cancer.
Elucidating molecular mechanisms underlying tumor suppression by the Rb1 gene, particularly in cell cycle regulation, with the aim of targeting this pathway for cancer therapy
Cancer Epigenetics, Wnt biology, Acute Myeloid Leukemia
Research focuses on the role of bioactive sphingolipid metabolites, sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) in cancer progression and metastasis, with the aim of targeting these signaling pathways for cancer therapy.
Exploiting nuclear hormone receptor signaling pathways in the prevention and treatment of lung cancer; drug resistance in lung cancer.
Research involves showing the direct interaction between FAK and IGF-1R signal transduction proteins in mammalian and cancer cells. Has patented the invention of novel small molecules that disrupt FAK and IGF-1R protein interactions.
Targeting the prostate tumor stem cell therapeutically in effort to eliminate the source of recurrent prostate cancer.
Drug development of novel agents; preclinical tumor models; mechanistic studies on drugs with novel targets; steroid hormones and their potential as an antiproliferative agent and development of novel approaches in prostate cancer.
My research aims to develop effective immune therapies of cancer, capable of selectively activating effector and memory-type CTLs and Th1 cells and promoting their selective accumulation in tumor tissues.
Mechanism of anti-apoptotic protein function and regulation in cancer cells.
Jacobs School of Medicine & Biomedical Sciences
Current cancer research focus involves light-activated drug delivery and liposome-based vaccine adjuvants.
University at Buffalo School of Pharmacy & Pharmaceutical Sciences
Development of models of pharmacological target-mediated drug disposition and dynamics, and the experimental validation of the primary determinants of PK/PD profiles of drugs that exhibit such phenomena
Activities have focused upon the role for the androgen receptor in prostate cancer recurrence after androgen deprivation therapy and racial differences in prostate cancer aggressiveness.
Development of “Multifunctional Agents” for tumor imaging and therapy.
The laboratory focuses on understanding tumor signaling and growth regulation in prostate cancer and uses this information to identify novel therapeutic and imaging targets for this disease.
Research is focused on the use of advanced imaging techniques such as magnetic resonance imaging, (MRI), computed tomography (CT) and optical molecular imaging techniques in preclinical and clinical studies.
Cell biology and biophysics of membranes and membrane function; use of liposomal drug carriers to improve the efficacy of cancer therapeutics.
Understanding the molecular and cellular basis of tumor cell heterogeneity and developing novel therapeutics targeting cancer stem cells.
Identification of regulators of tumor cell growth control through biochemical and cell-based approaches; development of targeted cancer therapeutics.
Research is focused on the role of genetic and epigenetic changes in bladder and prostate cancer in order to decipher the molecular landscape of the diseases, and to point to novel strategies for improved treatment. Research is also conducted in the area of prostate cancer racial health disparities; specifically, the role of DNA methylation and vitamin D deficiency in aggressiveness of prostate cancer among African-American men.
Research is focused on tumor microenvironment and molecular signaling in prostate cancer.
Non-enzymatic functions of prolidase, modulation of plasma protein degradation for development of protein therapeutics and disease biomarkers, EGFR- and HER2-directed cancer drug discovery and development.