I joined Roswell Park’s Leukemia Service in the Department of Medicine in March 2010. I treat patients with blood disorders, specifically acute myeloid and lymphoid leukemias, as well as bone marrow failure syndromes such as aplastic anemia and myelodysplastic syndrome (MDS). The MDS Foundation recognizes our MDS program as an MDS Center of Excellence. I am an Associate Professor at the State University of New York (SUNY) at Buffalo and a faculty member of the Roswell Park Comprehensive Cancer Center-SUNY Buffalo graduate training programs in the departments of Pharmacology and Therapeutics, Translational Medicine and Immunology.
I joined Roswell Park following completion of a five-year medical oncology and hematology fellowship at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital in Baltimore, MD, where I also completed my internal medicine residency, in 2005. I completed my medical training at the University of North Carolina School of Medicine, Chapel Hill, NC, in 2002, earning my degree as a Doctor of Medicine with Distinction.
I am board certified in hematology, oncology and internal medicine and hold medical licenses in New York and Maryland. I am a member of multiple professional organizations, including the American Society of Hematology, the American Association for Cancer Research, the Society for Immunotherapy of Cancer and the American Society of Oncology.
My research is focused on the mechanism of hypomethylating drugs (HMAs) in patients with myeloid cancer, specifically the contribution of the immune system to these responses. We have examined how HMAs can cause re-expression of proteins in cancer cells that can be targeted by the immune system. I have authored/co-authored more than 50 peer-reviewed publications.
- Garcia-Manero G, Roboz G, Walsh K, Kantarjian H, Ritchie E, Kropf P, O'Connell C, Tibes R, Lunin S, Rosenblat T, Yee K, Stock W, Griffiths E, Mace J, Podoltsev N, Berdeja J, Jabbour E, Issa JJ, Hao Y, Keer HN, Azab M, Savona MR. Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial. Lancet Haematol. 2019;6(6):e317-e327.
- Roloff GW, Griffiths EA. When to obtain genomic data in acute myeloid leukemia (AML) and which mutations matter.Blood Adv. 2018 Nov 13;2(21):3070-3080.
- El Chaer F, Ali OM, Sausville EA, Law JY, Lee ST, Duong VH, Baer MR, Koka R, Singh ZN, Wong J, Yared JA, Griffiths EA, Emadi A. Treatment of CD19-positive mixed phenotype acute leukemia with blinatumomab. Am J Hematol. 2019 Jan;94(1):E7-E8.
- Griffiths EA, Srivastava P*, Matsuzaki J, Brumberger Z*, Wang ES, Kocent J, Miller A, Paluch BE*, Lutgen-Dunckley LE, Martens BL, Odunsi K, Karpf AR, Nemeth MJ. NY-ESO-1 Vaccination in Combination with Decitabine Induces Antigen-Specific T-Lymphocyte Responses in Patients with High-Grade Myeloid Malignancy. Clinical Cancer Research. 2018;24:1019-1029.
5. 18. Krönke J, Fink EC, Hollenbach PW, MacBeth K, Hurst EN, Udeshi ND, Chamberlain PP, Mani DR, Man HW, Gandhi AK, Svinkina T, Schneider RK, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers BE, Carr SA, Chopra R, Ebert BL. Lenalidomide induces ubiquitination and degradation of casein kinase 1A1 in del(5q) MDS. Nature. 2015;523(7559):183-8.