Mukund Seshadri

Mukund Seshadri

DDS, PhD

Special Interests:

Vascular biology of head and neck cancers Chemoprevention of oral cancer Multimodal imaging (CT, US, Photoacoustic imaging)

Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • Chair, Department of Oral Oncology
  • Director, Center for Oral Oncology
  • Professor of Oncology
State University of New York at Buffalo
  • Member, Medical Physics Program

Research

Research Overview:

Research in my laboratory is focused on three areas: (i) the use of advanced imaging methods such as MRI, CT in preclinical models and in patients to study tumor angiogenesis and response of tumors to novel vascular targeted therapies, (ii) investigation into the potential of imaging-guided therapies for oral cancers, and, (iii) development of novel multifunctional and multimodal nanoparticles for targeted imaging and therapy of cancer. The work is interdisciplinary in nature and draws on concepts from biophysics, cancer biology, pharmacology, molecular biology and therapeutics. Given my clinical background, I feel strongly about pursuing a research program that addresses clinically-relevant questions in the laboratory setting and potentially translates the knowledge gained into meaningful outcomes for patients.

Sources of funding: National Cancer Institute, National Institute of Dental and Craniofacial Research, National Center for Research Resources, American Brain Tumor Association, American Cancer Society, Roswell Park Alliance Foundation.


Publications

Key Publications

Ku SY, Rosario S, Wang Y, Mu P, Seshadri M, Goodrich ZW, Goodrich MM, Labbé DP, Gomez EC, Wang J, Long HW, Xu B, Brown M, Loda M, Sawyers CL, Ellis L, Goodrich DW. Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance. Science. 2017 Jan 6;355(6320):78-83

Rich L and Seshadri M. Photoacoustic Imaging of Salivary Glands. Biomed Opt Express. 2015 Jul. 6(9):3157-62

Law WC, Xu Z, Yong KT, Liu X, Swihart MT, Seshadri M and Prasad PN. Manganese-doped near-infrared emitting nanocrystals for in vivo biomedical imaging. Opt. Express. 2016;24(16):17553-17561. Rich L and Seshadri M. Photoacoustic imaging of tumor and normal tissue response to radiation. Sci Rep. 2016 Feb 7;6:21237.

Rich LJ, Winslow T, Repasky EA, Seshadri M, Singh AK. Enhanced tumor perfusion by systemic heating in a patient with head and neck cancer:

Folaron M, Seshadri M. Bioluminescence and MR Imaging of the Safety and Efficacy of Vascular Disruption in Gliomas. Mol Imaging Biol. 2016 Dec;18(6):860-869.

Bothwell KD, Shaurova T, Merzianu M, Suresh A, Kuriakose MA, Johnson CS, Hershberger PA, Seshadri M. Impact of Short-term 1,25-Dihydroxyvitamin D3 on the Chemopreventive Efficacy of Erlotinib against Oral Cancer. Cancer Prev Res (Phila). 2015 Sep;8(9):765-76.{Cover Feature}

Rich LJ, Seshadri M. Photoacoustic imaging of vascular hemodynamics: Validation with BOLD MRI. Radiology 2015. 275(1):110-8. {Featured on Science to Practice}

Zhang Y, Jeon M, Rich LJ, Hong H, Geng J, Zhang Y, Shi S, Barnhart TE, Alexandridis P, Huizinga JD, Seshadri M, Cai W, Kim C and Lovell JF. Non-invasive multimodal functional imaging of the intestine with frozen micellar napthalocyanines. Nature Nanotechnol. 2014 Aug;9(8):631-8 Wang E, Pili R and Seshadri M. Modulation of chemotherapeutic efficacy by VDAs: Optimizing the sequence and schedule. J Clin Oncol. 2012 Mar1; 30(7):760-1.