Specializing In:Lung cancer therapeutics Vitamin D-based combination therapies
Research Interests:Chemoprevention of aerodigestive malignancies Elucidating the effects of e-cigarettes and tobacco smoke exposure on the airway epithelium Novel approaches to exploiting vitamin D metabolites in lung cancer treatment
About Pamela Hershberger
- Associate Professor of Oncology
- Associate Dean, Graduate Education
- Department of Educational Affairs
Education and Training:
- Post-doctoral - Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI
- Post-doctoral - Department of Surgery, University of Pittsburgh, Pittsburgh, PA
- PhD - Department of Biochemistry, Case Western Reserve University, Cleveland, OH
- University of Wisconsin, Madison, WI
- University of Pittsburgh, Pittsburgh, PA
- American Association for Cancer Research
Honors & Awards:
- 2019 - Graduate Student Association Award for Faculty Excellence in Mentoring and Teaching
- 2018 - Dean's Award for Excellence in Graduate Education
Work within my laboratory focuses on the prevention and treatment of lung cancer. Specifically, we seek to establish and understand the role of vitamin D metabolites in delaying lung tumor development and progression. Ongoing projects are designed to: (1) establish the role of dietary vitamin D3 in preventing lung cancer; (2) exploit vitamin D-mediated suppression of the epithelial-mesenchymal transition to prevent failure of molecularly targeted agents in lung cancer; and (3) identify novel strategies for overcoming vitamin D resistance in molecularly defined subsets of lung cancer.
Work in my laboratory is supported by NIH/NCI and the Roswell Park Alliance Foundation.
Featured on Cancer Talk
- Upadhyay SK, Verone A, Shoemaker S, Qin M, Liu S, Campbell M, Hershberger PA. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) signaling capacity and the epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC): Implications for use of 1,25(OH)2D3 in NSCLC treatment. Cancers (Basel). 2013 Nov 8;5(4):1504-21.
- Verone-Boyle AR, Shoemaker S, Attwood K, Morrison CD, Hershberger PA. Diet-Derived 25-hydroxyvitamin D3 activates VDR target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo. Oncotarget. 2016. 7(1):995-1013.
- Liu C, Shaurova T, Shoemaker S, Petkovich M, *Hershberger PA, *Wu Y. *Co-corresponding authors. Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer. Molecular Pharmaceutics. 2018. 15:3216-3226.
- Shaurova T, Dy GK, Battaglia S, Hutson A, Zhang L, Zhang Y, Lovly CM, Seshadri M, Goodrich DW, Johnson CS, Hershberger PA. Vitamin D3 metabolites demonstrate prognostic value in EGFR-mutant lung adenocarcinoma and can be deployed to oppose acquired therapeutic resistance. Cancers 2020. 12:675.
- Shaurova T, Zhang L, Goodrich DW, Hershberger PA. Understanding Histologic Transformation as a Path to Targeted Therapy Failure in EGFR-mutant Non-Small Cell Lung Cancer Frontiers in Genetics-Genomic Medicine, 2020.