Dr. McLean is a Buffalo Spree Top Doctor! See all of our physicians who made this year's list.
Cancers Treated:
Specializing In:
Cancers of the ovaries, uterus, cervix and vulva/vagina Surgical management of gynecologic malignancies including laparotomy, robotic and conventional laparoscopy, complex pelvic surgeries including bowel and urologic components Chemotherapy and clinical trials Primary radiation for patients unable to undergo surgeryResearch Interests:
Comprehensive care for women with gynecologic cancers Translational laboratory research to discover new cancer treatments Mentorship and education of traineesAbout Karen McLean
Biography:
I am a board-certified gynecologic oncologist with extensive experience as a principal investigator running a basic science laboratory concurrent with an active clinical gynecologic oncology practice including comprehensive surgical and chemotherapy care. I am committed to advancing our understanding of gynecologic cancers with the goal of improving outcomes for our patients.
Positions
- Associate Professor of Oncology
- Department of Gynecologic Oncology
- Department of Pharmacology & Therapeutics
- Dr. M. Steven Piver Endowed Professorship in Gynecologic Oncology
Background
Education and Training:
- 1995-2004 - PhD - Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI
- 1995-2004 - MD - Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI
Residency:
- 2004 -2008 - Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI
Fellowship:
- 2008 - 2011 - Gynecologic Oncology, University of Michigan, Ann Arbor, MI
Board Certification:
- Obstetrics & Gynecology - American Board of Obstetrics and Gynecology
- Gynecologic Oncology - American Board of Obstetrics and Gynecology
Professional Memberships:
- American Association for Cancer Research
- Society of Gynecologic Oncology
Honors & Awards:
- Department of Defense Ovarian Cancer Academy
Research
Research Overview:
Featured on Cancer Talk
Publications
Tan L, Tondo-Steele K, Foster C, McIlwain C, Bolland DE, Crawford HC, Sciallis A, McLean K. Inhibition of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells to Antiestrogen Therapy. Cancers 14:4675, 2022. PMC9564160
McLean K, Tan L, Bolland DE, Coffman LG, Peterson LF, Talpaz M, Neamati N, Buckanovich RJ:
Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth.
Oncogene 38(9): 1576-1584, 2018. PM30305729
Hacker KE, Bolland DE, Tan L, Saha AK, Niknafs YS, Markovitz DM, McLean K: The DEK Oncoprotein
Functions in Ovarian Cancer Growth and Survival. Neoplasia 20(12): 1209-1218, 2018. PM30412857
/PMC6226625
Stasenko M, Plegue M, Sciallis AP, McLean K: Clinical response to antiestrogen therapy in platinum-resistant
ovarian cancer patients and the role of tumor estrogen receptor expression status. International
journal of gynecological cancer: official journal of the International Gynecological Cancer Society 25(2):
222-8, 2015. PM25500503
McLean K, Gong Y, Choi Y, Deng N, Yang K, Bai S, Cabrera L, Keller E, McCauley L, Cho KR,
Buckanovich RJ: Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem
cells and tumorigenesis via altered BMP production. J Clin Invest 121(8): 3206-19, 2011. PM21737876
/PMC3148732