Qian Liu Landscape Qian Liu-Portrait-headshot

Qian Liu

PhD

Specializing In:

Clinical Trials Computational Biology

Special Interests:

Big data representation and comprehension Reproducible bioinformatics analysis

About Qian Liu

Biography:

I joined the Department of Biostatistics & Bioinformatics faculty at Roswell Park Comprehensive Cancer Center as an Assistant Professor of Oncology in October 2019. Prior to that, I was a post-doc affiliate supervised by Dr. Martin Morgan, in the Bioconductor Core Team.

My research interests are in 1) the development of statistical methodology, and application to collaborative clinical and biomedical projects; 2) the development of computational tools in deciphering very large cancer genomic data, to facilitate the scalability and reproducibility of bioinformatics analysis.

My interdisciplinary training in pharmaceutics, molecular biology, and data science has enabled me a solid understanding of the statistical principles behind current best practices in the clinical trials and high-throughput genomic data analysis. I'm passionate about working with clinicians and biologists in translating their data into knowledge.

Positions

Roswell Park Comprehensive Cancer Center

  • Assistant Professor of Oncology
  • Department of Biostatistics & Bioinformatics

Background

Education and Training:

  • 2014-2017 - PhD - Biostatistics, State University of New York at Buffalo, Buffalo, NY
  • 2011-2014 - MA - Biostatistics, State University of New York at Buffalo, Buffalo, NY

Professional Memberships:

  • Society for Immunotherapy of Cancer (SITC)
  • American Statistical Association (ASA)
  • International Society for Computational Biology (ISCB)
  • American Association for Cancer Research (AACR)
  • American Society of Human Genetics (ASHG)

Professional Experience:

  • 2017-2019 - Post-Doctoral Research Affiliate, Bioconductor Core Team, Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY

Publications

Zhu Q, Zhang J, Chen Y, Hu Q, Shen H, Huang RY, Liu Q, Kaur J, Long M, Battaglia S, Eng KH, Lele SB, Zsiros E, Villella J, Lugade A, Yao S, Liu S, Moysich K, Odunsi KO. Whole-exome sequencing of ovarian cancer families uncovers putative predisposition genes. Int J Cancer, 2020; 146(8):2147-2155. PMCID: PMC7065147

Karaesmen E, Hahn T, Dile AJ, Rizvi AA, Wang J, Wang T, Haagenson MD, Preus L, Zhu Q, Liu Q, Yan L, Liu S, Haiman CA, Stram D, Pooler L, Sheng X, Van Den Berg D, Brock G, Webb A, McCarthy PL, Pasquini MC, Spellman SR, Lee SJ, Paczesny S, Sucheston-Campbell LE. Multiple functional variants in the IL1RL1 region are pretransplant markers for risk of GVHD and infection deaths. Blood Adv, 2019; 3(16):2512-2524. PMCID: PMC6712530

Liu Q, Hu Q, Yao S, Kwan ML, Roh JM, Zhao H, Ambrosone CB, Kushi LH, Liu S, Zhu Q. SeqSQC: A Bioconductor Package for Evaluating the Sample Quality of Next-generation Sequencing Data. Genomics Proteomics Bioinformatics, 2019; 7(2):211-218. PMCID: PMC6620264

Liu Q, Yao S, Zhao H, Hu Q, Kwan ML, Roh JM, Ambrosone CB, Kushi LH, Liu S, Zhu Q. Early-onset triple-negative breast cancer in multiracial/ethnic populations: Distinct trends of prevalence of truncation mutations. Cancer Med, 2019; 8(4):1845-1853. PMC6488149

Zhu Q, Yan L, Liu Q, Zhang C, Wei L, Hu Q, Preus L, Clay-Gilmour AI, Onel K, Stram DO, Pooler L, Sheng X, Haiman CA, Zhu X, Spellman SR, Pasquini M, McCarthy PL, Liu S, Hahn T, Sucheston-Campbell LE. Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation. Blood, 2018; 131(22):2490-2499. PMCID: PMC5981168

Karaesmen E, Rizvi AA, Preus LM, McCarthy PL, Pasquini MC, Onel K, Zhu X, Spellman S, Haiman CA, Stram DO, Pooler L, Sheng X, Zhu Q, Yan L, Liu Q, Hu Q, Webb A, Brock G, Clay-Gilmour AI, Battaglia S, Tritchler D, Liu S, Hahn T, Sucheston-Campbell LE. Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant. Blood, 2017; 130(13):1585-1596. PMCID: PMC5620418

Clay-Gilmour AI, Hahn T, Preus LM, Onel K, Skol A, Hungate E, Zhu Q, Haiman CA, Stram DO, Pooler L, Sheng X, Yan L, Liu Q, Hu Q, Liu S, Battaglia S, Zhu X, Block AW, Sait SNJ, Karaesmen E, Rizvi A, Weisdorf DJ, Ambrosone CB, Tritchler D, Ellinghaus E, Ellinghaus D, Stanulla M, Clavel J, Orsi L, Spellman S, Pasquini MC, McCarthy PL, Sucheston-Campbell LE. Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood Adv, 2017; 1(20):1717-1728. PMCID: PMC5728332

Zhu Q, Shepherd L, Lunetta KL, Yao S, Liu Q, Hu Q, Haddad SA, Sucheston-Campbell L, Bensen JT, Bandera EV, Rosenberg L, Liu S, Haiman CA, Olshan AF, Palmer JR, Ambrosone CB. Trans-ethnic follow-up of breast cancer GWAS hits using the preferential linkage disequilibrium approach. Oncotarget, 2016; 7(50):83160-83176. PMCID: PMC5341253

Kwan ML, Yao S, Lee VS, Roh JM, Zhu Q, Ergas IJ, Liu Q, Zhang Y, Kutner SE, Quesenberry CP Jr, Ambrosone CB, Kushi LH. Race/ethnicity, genetic ancestry, and breast cancer-related lymphedema in the Pathways Study. Breast Cancer Res Treat, 2016; 159(1):119-129. PMCID: PMC5010992

Liu Q, Cirulli ET, Han Y, Yao S, Liu S, Zhu Q. Systematic assessment of imputation performance using the 1000 Genomes reference panels. Brief Bioinform, 2015; 16(4):549-562. PMCID: PMC4580532

Khoury T, Liu Q, Liu S. Delay to formalin fixation effect on HER2 test in breast cancer by dual-color silver-enhanced in situ hybridization (Dual-ISH). Appl Immunohistochem Mol Morphol, 2014; 22(9):688-695. PMID: 24992176

Mhawech-Fauceglia P, Wang D, Kim G, Sharifian M, Chen X, Liu Q, Lin YG, Liu S, Pejovic T. Expression of DNA repair proteins in endometrial cancer predicts disease outcome. Gynecol Oncol, 2014; 132(3):593-598. PMID: 24508840