Finding ways to gain control over cancer 

Since 2008, the major goal of Dr. Gurova’s lab has been identifying novel targets for anti-cancer treatment and approaches to modulate these targets. 

Several novel small molecules with anti-cancer properties were identified in our lab. One of them, curaxin CBL0137, is currently being tested in clinical trials. 

Lab Research

Research focus

Image
Cell slides from a microscope

Curaxins were discovered in a cell-based screening for novel type of activators of tumor suppressor p53.  The search for the mechanism of action of curaxins brought us to the field of chromatin biology, since curaxins appeared to be the “first in the class” – pure “chromatin damaging” compounds.  

The current focus of our research is understanding the chromatin alterations in cancer, the reasons chromatin destabilization is more toxic for tumor than for normal cells, how chromatin stability is regulated, and whether it is possible to utilize some chromatin remodeling factors, e.g., histone chaperone, as targets for anti-cancer treatment. 

See the science: 

Collaborations

We work with research partners in Sydney, Moscow, and Cleveland.

Learn More

Publications

Check out some of Dr. Gurova’s recent articles, and view her research on PubMed.

Read the Research

Meet our team

The staff at the Gurova lab has the best and the brightest scientists.

Meet Our Team

Inside the Gurova Lab

We’re studying, publishing, presenting, and accomplishing great things.

Take a Look Inside
Contact Information

Contact the Gurova Lab

Email: Katerina.Gurova@RoswellPark.org  
Phone: 716-845-4760 
Office location: Center for Genetics & Pharmacology (CGP) L3-301A 
Lab Location: Center for Genetics & Pharmacology (CGP) L3-121 & 122 

Department of Cell Stress Biology  
Roswell Park Comprehensive Cancer Center 
Elm and Carlton Streets 
Buffalo, NY 14263