The Gurova Lab is making a global impact through collaborations with cancer scientists across the U.S. and around the world.
Childrens Cancer Institute Australia (CCIA)
Our long-term collaborators include many investigators from CCIA in Sydney. We continue to collaborate on studies aimed at finding novel therapies for pediatric malignancies, such as:
- Neuroblastoma with Michelle Haber, Murray Norris, and Glenn Marshall;
- Leukemia with Michelle Henderson and Richard Lock; and
- DIPG with David Ziegler.
Our recent mutual papers with CCIA include:
- Xiao L, et al. The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression. Front Oncol. 2022 May 23;12:863329. doi: 10.3389/fonc.2022.863329. PMID: 35677155; PMCID: PMC9168530.
- Xiao L, et al. Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma. Clin Cancer Res. 2021 Aug 1;27(15):4338-4352. doi: 10.1158/1078-0432.CCR-20-2357. Epub 2021 May 16. PMID: 33994371; PMCID: PMC8380471.
- Ehteda A, et al. Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG. Cell Rep. 2021 Apr 13;35(2):108994. doi: 10.1016/j.celrep.2021.108994. PMID: 33852836.
- Somers K, et al. Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia. Int J Cancer. 2020 Apr 1;146(7):1902-1916. doi: 10.1002/ijc.32582. Epub 2019 Aug 8. PMID: 31325323.
Russian National Cancer Center, Moscow
We have a long and successful collaboration with the lab of Marianna Yakubovskaya at the Russian National Cancer Center in Moscow. Her team has expertise in DNA structure and biology, interactions of small molecules with DNA, and chemical carcinogenesis. Together, we explore the effects of different non-carcinogenic molecules on DNA and chromatin.
Our recent papers with Dr. Yakubovskaya’s team include:
- Kirsanov K, Fet al. Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling. Cancer Prev Res (Phila). 2020 Jan;13(1):53-64. doi: 10.1158/1940-6207.CAPR-19-0198. Epub 2019 Oct 25. PMID: 31653646.
- Leonova K,et al. TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells. Elife. 2018 Feb 5;7:e30842. doi: 10.7554/eLife.30842. PMID: 29400649; PMCID: PMC5815852.
- Safina A, et al K. FACT is a sensor of DNA torsional stress in eukaryotic cells. Nucleic Acids Res. 2017 Feb 28;45(4):1925-1945. doi: 10.1093/nar/gkw1366. PMID: 28082391; PMCID: PMC5389579.
- Leonova K, et al. TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells. Elife. 2018 Feb 5;7:e30842. doi: 10.7554/eLife.30842. PMID: 29400649; PMCID: PMC5815852.
Cleveland Clinic
We work with several researchers at Cleveland Clinic's Lerner Research Institute, particularly George Stark. He assisted with characterizing the effects of quinacrine and curaxin against several different cancers, including NSCLC and glioblastoma.
Our mutual papers with Dr. Stark include:
- Dermawan JK, et al. Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models. Cancer Res. 2016 Apr 15;76(8):2432-42. doi: 10.1158/0008-5472.CAN-15-2162. Epub 2016 Feb 26. PMID: 26921329; PMCID: PMC4873320.
- Dermawan JK, et al. Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-κB, and cell-cycle progression in non-small cell lung cancer. Mol Cancer Ther. 2014 Sep;13(9):2203-14. doi: 10.1158/1535-7163.MCT-14-0013. Epub 2014 Jul 15. PMID: 25028470; PMCID: PMC4156551.
- Gurova KV, et al. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17448-53. doi: 10.1073/pnas.0508888102. Epub 2005 Nov 15. PMID: 16287968; PMCID: PMC1297696.
Contact the Gurova Lab
Email: Katerina.Gurova@RoswellPark.org
Phone: 716-845-4760
Office location: Center for Genetics & Pharmacology (CGP) L3-301A
Lab Location: Center for Genetics & Pharmacology (CGP) L3-121 & 122
Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263