Chromatin damaging anti-cancer therapy
DNA damage is any chemical modification of DNA (e.g., double- and single-strand breaks, base modifications). Chromatin damage is the loss of histones from nucleosomes in the absence of chemical modifications of DNA.
In many cases, both types of damage are observed together because DNA damage may destabilize nucleosomes, and loss of histones makes DNA more sensitive to chemical modifications.
In contrast to DNA damage, the causes and consequences of chromatin damage are poorly studied.
Contact the Gurova Lab
Email: Katerina.Gurova@RoswellPark.org
Phone: 716-845-4760
Office location: Center for Genetics & Pharmacology (CGP) L3-301A
Lab Location: Center for Genetics & Pharmacology (CGP) L3-121 & 122
Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263