Check out the latest articles, abstracts, editorials, and more from the Gurova Lab.
Comparison of cell response to chromatin and DNA damage
- Journal: Nucleic Acids Research, October 2023
- Authors: Artyom Luzhin, Priyanka Rajan, Alfiya Safina, Katerina Leonova, Aimee Stablewski, Jianmin Wang, Denisha Robinson, Natalia Isaeva, Omar Kantidze, Katerina Gurova
- Citation: Nucleic Acids Research, 2023, 1–20
Can aggressive cancers be identified by the "aggressiveness" of their chromatin?
- Journal: BioEssays, April 2022
- Author: Katerina Gurova
- Citation: BioEssays. 2022 Apr 22:e2100212
The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression
- Journal: Frontiers in Oncology, May 2022
- Authors: Xiao L, Karsa M, Ronca E, Bongers A, Kosciolek A, El-Ayoubi A, Revalde JL, Seneviratne JA, Cheung BB, Cheung LC, Kotecha RS, Newbold A, Bjelosevic S, Arndt GM, Lock RB, Johnstone RW, Gudkov AV, Gurova KV, Haber M, Norris MD, Henderson MJ, Somers K
- Citation: Front Oncol. 2022 May 23;12:863329
FACT maintains nucleosomes during transcription and stem cell viability in adult mice
- Journal: EMBO Reports, February 2022/li>
- Authors: Goswami I, Sandlesh P, Stablewski A, Toshkov I, Safina AF, Magnitov M, Wang J, Gurova K
- Citation: EMBO Rep. 2022 Feb 18:e53684
More publications
- Dutta N, et al. Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways. J Ethnopharmacol. 2022 Jan 30;283:114666. doi: 10.1016/j.jep.2021.114666. Epub 2021 Sep 27. PMID: 34592338.
- Xiao L, et al. Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma. Clin Cancer Res. 2021 Aug 1;27(15):4338-4352. doi: 10.1158/1078-0432.CCR-20-2357. Epub 2021 May 16. PMID: 33994371; PMCID: PMC8380471.
- Ehteda A, et al. Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG. Cell Rep. 2021 Apr 13;35(2):108994. doi: 10.1016/j.celrep.2021.108994. PMID: 33852836.
- Chen M, Bet al. Stimulation of an anti-tumor immune response with "chromatin-damaging" therapy. Cancer Immunol Immunother. 2021 Jul;70(7):2073-2086. doi: 10.1007/s00262-020-02846-8. Epub 2021 Jan 13. PMID: 33439292; PMCID: PMC8726059.
- Prendergast L, Hong E, Safina A, Poe D, Gurova K. Histone chaperone FACT is essential to overcome replication stress in mammalian cells. Oncogene. 2020 Jul;39(28):5124-5137. doi: 10.1038/s41388-020-1346-9. Epub 2020 Jun 12. PMID: 32533099; PMCID: PMC7343669.
- Kim M, Powers CA, Curtin LI, Fisher DT, Sexton S, Gurova KV, Skitzki JJ, Iyer RV. A Translational Hepatic Artery Infusion (HAI) Model for Hepatocellular Carcinoma in Woodchucks. J Surg Res. 2020 Jul;251:126-136. doi: 10.1016/j.jss.2020.02.002. Epub 2020 Mar 3. PMID: 32143057; PMCID: PMC7830851.
- Sandlesh P, Safina A, Goswami I, Prendergast L, Rosario S, Gomez EC, Wang J, Gurova KV. Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation. iScience. 2020 Jun 26;23(6):101177. doi: 10.1016/j.isci.2020.101177. Epub 2020 May 18. PMID: 32498018; PMCID: PMC7267732.
- Kantidze OL, Gurova KV, Studitsky VM, Razin SV. The 3D Genome as a Target for Anticancer Therapy. Trends Mol Med. 2020 Feb;26(2):141-149. doi: 10.1016/j.molmed.2019.09.011. Epub 2019 Oct 31. PMID: 31679987.
- Kirsanov K, Fetisov T, Lesovaya EA, Maksimova V, Trukhanova L, Antoshina E, Gor'kova T, Morozova O, Safina A, Fleyshman D, Salimov R, Shipaeva E, Ivanov R, Leonov A, Purmal AA, Belitsky GA, Gudkov AV, Gurova KV, Yakubovskaya MG. Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling. Cancer Prev Res (Phila). 2020 Jan;13(1):53-64. doi: 10.1158/1940-6207.CAPR-19-0198. Epub 2019 Oct 25. PMID: 31653646.
- Somers K, Kosciolek A, Bongers A, El-Ayoubi A, Karsa M, Mayoh C, Wadham C, Middlemiss S, Neznanov N, Kees UR, Lock RB, Gudkov A, Sutton R, Gurova K, Haber M, Norris MD, Henderson MJ. Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia. Int J Cancer. 2020 Apr 1;146(7):1902-1916. doi: 10.1002/ijc.32582. Epub 2019 Aug 8. PMID: 31325323.
- Chang HW, Nizovtseva EV, Razin SV, Formosa T, Gurova KV, Studitsky VM. Histone Chaperone FACT and Curaxins: Effects on Genome Structure and Function. J Cancer Metastasis Treat. 2019;5:78. doi: 10.20517/2394-4722.2019.31. Epub 2019 Nov 29. PMID: 31853507; PMCID: PMC6919649.
- Jean MJ, Zhou D, Fiches G, Kong W, Huang H, Purmal A, Gurova K, Santoso NG, Zhu J. Curaxin CBL0137 has the potential to reverse HIV-1 latency. J Med Virol. 2019 Aug;91(8):1571-1576. doi: 10.1002/jmv.25487. Epub 2019 May 1. PMID: 30989696; PMCID: PMC6599568.
- Kantidze OL, Luzhin AV, Nizovtseva EV, Safina A, Valieva ME, Golov AK, Velichko AK, Lyubitelev AV, Feofanov AV, Gurova KV, Studitsky VM, Razin SV. The anti-cancer drugs curaxins target spatial genome organization. Nat Commun. 2019 Mar 29;10(1):1441. doi: 10.1038/s41467-019-09500-7. PMID: 30926878; PMCID: PMC6441033.
- Gurova KV. Chromatin Stability as a Target for Cancer Treatment. Bioessays. 2019 Jan;41(1):e1800141. doi: 10.1002/bies.201800141. PMID: 30566250; PMCID: PMC6522245.
- Gurova K, Chang HW, Valieva ME, Sandlesh P, Studitsky VM. Structure and function of the histone chaperone FACT - Resolving FACTual issues. Biochim Biophys Acta Gene Regul Mech. 2018 Jul 25:S1874-9399(18)30159-7. doi: 10.1016/j.bbagrm.2018.07.008. Epub ahead of print. PMID: 30055319; PMCID: PMC6349528.
- Sandlesh P, Juang T, Safina A, Higgins MJ, Gurova KV. Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. PLoS One. 2018 Jun 28;13(6):e0199785. doi: 10.1371/journal.pone.0199785. PMID: 29953487; PMCID: PMC6023160.
- Leonova K, Safina A, Nesher E, Sandlesh P, Pratt R, Burkhart C, Lipchick B, Gitlin I, Frangou C, Koman I, Wang J, Kirsanov K, Yakubovskaya MG, Gudkov AV, Gurova K. TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells. Elife. 2018 Feb 5;7:e30842. doi: 10.7554/eLife.30842. PMID: 29400649; PMCID: PMC5815852.
- Nesher E, Safina A, Aljahdali I, Portwood S, Wang ES, Koman I, Wang J, Gurova KV. Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs. Cancer Res. 2018 Mar 15;78(6):1431-1443. doi: 10.1158/0008-5472.CAN-17-2690. Epub 2018 Jan 16. PMID: 29339544; PMCID: PMC5856628.
- Chang HW, Valieva ME, Safina A, Chereji RV, Wang J, Kulaeva OI, Morozov AV, Kirpichnikov MP, Feofanov AV, Gurova KV, Studitsky VM. Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins. Sci Adv. 2018 Nov 7;4(11):eaav2131. doi: 10.1126/sciadv.aav2131. PMID: 30417101; PMCID: PMC6221510.
- Attwood K, Fleyshman D, Prendergast L, Paszkiewicz G, Omilian AR, Bshara W, Gurova K. Prognostic value of histone chaperone FACT subunits expression in breast cancer. Breast Cancer (Dove Med Press). 2017 May 3;9:301-311. doi: 10.2147/BCTT.S126390. PMID: 28496363; PMCID: PMC5422336.
- Fleyshman D, Prendergast L, Safina A, Paszkiewicz G, Commane M, Morgan K, Attwood K, Gurova K. Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells. Oncotarget. 2017 Mar 28;8(13):20525-20542. doi: 10.18632/oncotarget.15656. PMID: 28423528; PMCID: PMC5400524.
- Safina A, Cheney P, Pal M, Brodsky L, Ivanov A, Kirsanov K, Lesovaya E, Naberezhnov D, Nesher E, Koman I, Wang D, Wang J, Yakubovskaya M, Winkler D, Gurova K. FACT is a sensor of DNA torsional stress in eukaryotic cells. Nucleic Acids Res. 2017 Feb 28;45(4):1925-1945. doi: 10.1093/nar/gkw1366. PMID: 28082391; PMCID: PMC5389579.
Contact the Gurova Lab
Email: Katerina.Gurova@RoswellPark.org
Phone: 716-845-4760
Office location: Center for Genetics & Pharmacology (CGP) L3-301A
Lab Location: Center for Genetics & Pharmacology (CGP) L3-121 & 122
Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263