Dr. Katerina Gurova came to Roswell Park Comprehensive Cancer Center from Cleveland BioLabs, where she served as Director of Anti-Cancer Drug Discovery. Before joining Cleveland BioLabs, she worked as a Project Scientist in the Department of Molecular Genetics at The Cleveland Clinic.
Dr. Gurova earned her medical degree from the Sechenov Medical Academy and a doctoral degree in experimental oncology from the Blokhin Cancer Research Center, both located in Moscow, Russia.
Dr. Gurova’s research interests are focused on the discovery and development of new anticancer drugs. Specifically, she identified a new class of prospective anticancer agents named curaxins which are capable of simultaneous targeting of several signal transduction pathways that are frequently deregulated in cancer, including p53 and NF-kappaB. Her laboratory at Roswell Park is working on deciphering molecular mechanisms, optimizing therapeutic properties of curaxins and on the development of new approaches to treatment of hormone-refractory prostate cancer.
Dr. Gurova is a member of the American Association for Cancer Research.
Dr. Gurova has authored several research articles and reviews on the mechanisms of cancer cell death. For a complete list of publications click here.
Major goal of our lab is the discovery of new anti-cancer agents through different approaches, their testing and early stage development as well as understanding of the mechanisms of their activity. We have molecules at different stage of development, including one, curaxin CBL0137, in clincial trial.
Our current focus area is chromatin remodeling factors, their role in normal development and disease, DNA damage detection and prevention. Specifically we are concentrated right now on a FAcilitates Chromatin Transcription (FACT) complex. We have found that it may be used as a marker of aggressive poorly differentiated cancers with low overall survival. We are in the process of validation of FACT as an anti-cancer target through identification and testing of chemical FACT inhibitors and genetically modified mice to see consequences of FACT inhibition for tumors and the whole organism.
We also believe that FACT may be involved in the protection of our genome from DNA damage through the control of DNA topology. FACT can detect abnormal or alternative DNA structures and convey signal to p53 activation. Thus FACT has been a sensor and mediator of a novel type of cell stress-DNA superhelical or torsional stress, which is the situation when DNA is over or undertwisted, and may result in DNA breaks.
New area of lab research is how chromatin stability is regulated, supported and ensured in eukaryotes, and how cancer cells manage to have their chromatin stable in spite of constant replication. Factors ensuring chromatin stability in cancer cells should be overactive and may present novel targets for anti-cancer therapy.
Kantidze OL, Luzhin AV, Nizovtseva EV, Safina A, Valieva ME, Golov AK, Velichko AK, Lyubitelev AV, Feofanov AV, Gurova KV, Studitsky VM, Razin SV. The anti-cancer drugs curacins target spatial genome organization. Nat Commun. 2019 Mar 29;10(1):1441. doi: 10.1038/s41467-019-09500-7. PMID :30926878
Gurova KV. Chromatin Stability as a Target for Cancer Treatment. Bioessays. 2019 Jan;41(1):e1800141. doi: 10.1002/bies.201800141. Review. PMID: 30566250
Chang HW, Valieva ME, Safina A, Chereji RV, Wang J, Kulaeva OI, Morozov AV, Kirpichnikov MP, Feofanov AV, Gurova KV, Studitsky VM. Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins. Sci Adv. 2018 Nov 7; 4(11):eaav2131. doi: 10.1126/sciadv.aav2131. eCollection 2018 Nov. PMID: 30417101
Gurova K, Chang HW, Valieva ME, Sandlesh P, Studitsky VM. Structure and function of the histone chaperone FACT – Resolving FACTual issues. Biochim Biophys Acta Gene Regul Mech. 2018 Jul 25. pii: S1874-9399(18)30159-7. doi: 10.1016/j.bbagrm.2018.07.008. [Epub ahead of print] Review. PMID: 30055319