Systems approaches to studying cancer metastasis and gene regulation
Our laboratory focuses on defining the underlying mechanisms that promote tumor progression and metastasis.
We take a systems biology approach investigating metabolic pathways, genetic and epigenetic regulation, and immune evasion mechanisms that selectively sustain the growth and progression of metastatic tumors.
Our research is supported by grants from the National Institutes of Health, the National Cancer Institute, the Susan G. Komen Foundation, and the Roswell Park Alliance Foundation.
- Low expression of miR-195 is associated with cell proliferation, glycolysis and poor survival in estrogen receptor (ER)-positive but not in triple negative breast cancer. Am J Cancer Res. 2021 Jun 15;11(6):3320-3334.
- Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Cancer Res. 2021 Jan 1;81(1):50-63
- Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 Feb 9;11(1):3441.
In 2020, Dr. Dasgupta was honored with a New Innovator Award from the director of the National Institutes of Health.
Graduate Student Tao Dai Earns Prestigious Breast Cancer Predoctoral Fellowship
His project for the Breast Cancer Research Initiative examines how the PFKFB4 enzyme prevents immune cells from attacking breast tumors, and how the enzyme increases the motility of TNBC cells, allowing them to spread to different organs.