Dasgupta Lab

Selected publications

• Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation. Sawant Dessai A, Elhalawany NA, Dai T, Jacobi JJ, Prechtl C, Dimeck AN, Morton SR, Long MD, Singh PK, Putluri N, Lopes M, Liu S, Smiraglia DJ, Gurova KV, Lund PJ, Gates LA, Jung SY, Dasgupta S. Nature Communications (2026).
• Differential bone morphology and hypoxia activity in skeletal metastases of ER+ and ER− breast cancer. Das A, Barry MM, Ernst CA, Dahiya R, Kim M, Rosario SR, Lo HC, Yu C, Dai T, Gugala Z, Zhang J, Dasgupta S, Wang H. Communications Biology (2024).
• TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer. Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, Karri D, Zhu B, Yang F, Coarfa C, O'Malley BW, Yi P. PNAS- Proceedings of the National Academy of the Sciences U S A (2023).
• Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Dai, T, Spencer R; Katsuta, E; Paterson, EJ; Novickis, AT; Dessai, Abhisha Sawant; Gomez, Eduardo Cortes; Zhu, B; Liu, S; Wang, H; Abrams, SI, Seshadri, M, Bshara, W, Dasgupta, S. Cell Reports (2022).
• Metabolic enzyme PFKFB4 activates oncogenic coactivator SRC-3 to drive breast cancer. Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O’Malley BW. Nature (2018).