Systems approaches to studying cancer metastasis and gene regulation
Our laboratory focuses on defining the underlying mechanisms that promote tumor progression and metastasis.
We take a systems biology approach investigating metabolic pathways, genetic and epigenetic regulation, and immune evasion mechanisms that selectively sustain the growth and progression of metastatic tumors.
Our research is supported by grants from the National Institutes of Health, the National Cancer Institute, the Susan G. Komen Foundation, and the Roswell Park Alliance Foundation.
Research directions
Discovering Metabolic Dysregulation in Cancer
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Decoding Tumor Microenvironment and Immune Response
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Defining Transcriptional and Epigenetic Regulation
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The Dasgupta Lab is looking for a highly motivated individuals to join our team. Check out our available positions!
Laboratory TechnicianResearch AssociateResearch Technologist
Selected publications
- Protocol to detect and quantify tumor hypoxia in mice using photoacoustic imaging. STAR Protoc. 2024 Jun 21;5(2):102993.
- Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Reports. 2022 Dec 6;41(10):111756.
- Transcriptional repression of SIRT3 potentiates mitochondrial aconitase activation to drive aggressive prostate cancer to the bone. Cancer Res. 2021 Jan 1;81(1):50-63.
- Metabolic enzyme PFKFB4 activates oncogenic coactivator SRC-3 to drive breast cancer. Nature. 2018 Apr 3; 556(7700):249-254.
In 2020, Dr. Dasgupta was honored with a New Innovator Award from the director of the National Institutes of Health.
Are you a graduate student?
Graduate students from any PhD track admitted to the Roswell Park Cancer Sciences Graduate Program and University of Buffalo MD/PhD Program are accepted for laboratory rotations. Email Dr. Dasgupta with your research interests.
Graduate Student Tao Dai Earns Prestigious Breast Cancer Predoctoral Fellowship
His project for the Breast Cancer Research Initiative examines how the PFKFB4 enzyme prevents immune cells from attacking breast tumors, and how the enzyme increases the motility of TNBC cells, allowing them to spread to different organs.
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Contact the Dasgupta Lab
Email: Subhamoy.Dasgupta@RoswellPark.org
Phone: 716-845-2461 or 716-845-2462
Lab Location: Center for Genetics & Pharmacology (CGP) L3-101- 106
Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263