Tumor intrinsic metabolic pathways significantly alter the tumor microenvironment (TME). Metabolic stress in TME influences aggressive tumor phenotype, and the hypoxic regions within the tumor exert an increased risk of metastasis by activating transcriptional programs.
TME consists of cellular components including stromal cells and immune cells, and characterized by lactic acidosis, hypoxia and secreted tumor-derived factors. We aim to define whether adaptive changes induced by TME contribute to enhanced invasiveness by allowing cancer cells to acquire cell-autonomous properties favoring site specific metastatic colonization.
In addition, altered tumor metabolism promotes an immunosuppressive TME which may diminish efficacy and response rate of immunotherapy. We are investigating the mechanisms that regulate TME properties compromising anti-tumor immune response.
Contact the Dasgupta Lab
Email: Subhamoy.Dasgupta@RoswellPark.org
Phone: 716-845-2461 or 716-845-2462
Lab Location: Center for Genetics & Pharmacology (CGP) L3-101- 106
Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263