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Sawant Dessai A, et al. Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Cancer Res. 2021 Jan 1;81(1):50-63. doi: 10.1158/0008-5472.CAN-20-1708. Epub 2020 Oct 28. PMID: 33115805; PMCID: PMC7878313.

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Katsuta E, et al. High MYC mRNA Expression Is More Clinically Relevant than MYC DNA Amplification in Triple-Negative Breast Cancer. Int J Mol Sci. 2019 Dec 28;21(1):217. doi: 10.3390/ijms21010217. PMID: 31905596; PMCID: PMC6981812.

Takahashi H, et al. High expression of Annexin A2 is associated with DNA repair, metabolic alteration, and worse survival in pancreatic ductal adenocarcinoma. Surgery. 2019 Aug;166(2):150-156. doi: 10.1016/j.surg.2019.04.011. Epub 2019 Jun 3. PMID: 31171367; PMCID: PMC6661011.

Blundon MA, Dasgupta S. Metabolic Dysregulation Controls Endocrine Therapy-Resistant Cancer Recurrence and Metastasis. Endocrinology. 2019 Aug 1;160(8):1811-1820. doi: 10.1210/en.2019-00097. PMID: 31157867; PMCID: PMC6620757.

Singh R, et al. TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. J Clin Invest. 2018 Jul 2;128(7):3129-3143. doi: 10.1172/JCI96060. Epub 2018 Jun 18. PMID: 29715200; PMCID: PMC6026011.

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Dasgupta S, et al. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 Apr;556(7700):249-254. doi: 10.1038/s41586-018-0018-1. Epub 2018 Apr 3. PMID: 29615789; PMCID: PMC5895503.

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Kaushik AK, et al. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016 May 19;7:11612. doi: 10.1038/ncomms11612. PMID: 27194471; PMCID: PMC4874037.

Nikolai BC, et al. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15;76(6):1463-75. doi: 10.1158/0008-5472.CAN-15-2383. Epub 2016 Feb 1. PMID: 26833126; PMCID: PMC4794399.

Zhu B, et al. Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading. Mol Cell. 2015 Dec 3;60(5):769-783. doi: 10.1016/j.molcel.2015.10.024. Epub 2015 Nov 21. PMID: 26611104; PMCID: PMC4671835.

Jin F, et al. A Novel [15N] Glutamine Flux using LC-MS/MS-SRM for Determination of Nucleosides and Nucleobases. J Anal Bioanal Tech. 2015 Oct;6(5):267. doi: 10.4172/2155-9872.1000267. Epub 2015 Aug 30. PMID: 27158554; PMCID: PMC4857768.

Fleet T, et al. SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E6068-77. doi: 10.1073/pnas.1519073112. Epub 2015 Oct 20. PMID: 26487680; PMCID: PMC4640775.

Kpetemey M, Dasgupta S, et al. MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. Mol Cancer. 2015 Aug 15;14:156. doi: 10.1186/s12943-015-0428-8. PMID: 26272794; PMCID: PMC4536591.

Rajendiran S, et al. MIEN1 promotes oral cancer progression and implicates poor overall survival. Cancer Biol Ther. 2015;16(6):876-85. doi: 10.1080/15384047.2015.1040962. PMID: 25996585; PMCID: PMC4622880.

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Dasgupta S, et al. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015 Mar 2;125(3):1174-88. doi: 10.1172/JCI76029. Epub 2015 Feb 9. PMID: 25664849; PMCID: PMC4362260.

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Dasgupta S, et al. Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med. 2014;65:279-92. doi: 10.1146/annurev-med-051812-145316. Epub 2013 Sep 16. PMID: 24111892; PMCID: PMC4327818.

Rajendiran S, et al. MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1. Mol Cancer. 2014 Nov 19;13:250. doi: 10.1186/1476-4598-13-250. PMID: 25406943; PMCID: PMC4246551.

Dasgupta S, O'Malley BW. Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology. J Mol Endocrinol. 2014 Oct;53(2):R47-59. doi: 10.1530/JME-14-0080. Epub 2014 Jul 14. PMID: 25024406; PMCID: PMC4152414.

Stashi E, et al. SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014 Feb 27;6(4):633-45. doi: 10.1016/j.celrep.2014.01.027. Epub 2014 Feb 13. PMID: 24529706; PMCID: PMC4096300.

Dasgupta S, et al. Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges. J Carcinog. 2012;11:4. doi: 10.4103/1477-3163.93001. Epub 2012 Feb 17. PMID: 22438770; PMCID: PMC3307249.

Dasgupta S, et al. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem. 2011 Jul 22;286(29):25935-46. doi: 10.1074/jbc.M111.254599. Epub 2011 May 31. PMID: 21628459; PMCID: PMC3138290.

Das S, et al. Signal transducer and activator of transcription 6 (STAT6) is a novel interactor of annexin A2 in prostate cancer cells. Biochemistry. 2010 Mar 16;49(10):2216-26. doi: 10.1021/bi9013038. PMID: 20121258.

Dasgupta S, et al. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. Oncogene. 2009 Aug 13;28(32):2860-72. doi: 10.1038/onc.2009.145. Epub 2009 Jun 8. PMID: 19503095; PMCID: PMC2726905.

Contact the Dasgupta Lab

Email: Subhamoy.Dasgupta@RoswellPark.org
Phone: 716-845-2461 or 716-845-2462
Lab Location: Center for Genetics & Pharmacology (CGP) L3-101- 106

Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263