- Sawant Dessai, A., Elhalawany, N.A., Dai, T. et al. Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation. Nat Commun (2026). https://doi.org/10.1038/s41467-026-74786-3
Press Release - Reavis HD, Chaubey AH, Smythers AL, Tisdale AA, Tracz A, Dimeck AN, Maraszek KE, Cortes Gomez E, Paulo JA, Dasgupta S, Gygi SP, Feigin ME. Alprazolam Reduces Inflammatory Cytokine Production in Pancreatic Cancer-Associated Fibroblasts. Cancer Res Commun. 2026 May 1;6(5):1048-1060. doi: 10.1158/2767-9764.CRC-25-0472. PMID: 41996628; PMCID: PMC13147339.
- da Silva Fernandes T, Gillard BM, Dai T, Martin JC, Chaudhry KA, Dugas SM, Fisher AA, Sharma P, Wu R, Attwood KM, Dasgupta S, Takabe K, Rosario SR, Bianchi-Smiraglia A. Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer. Sci Rep. 2025 Jan 7;15(1):1061. doi: 10.1038/s41598-024-85094-5. PMID: 39774345; PMCID: PMC11707137.
- Das A, Barry MM, Ernst CA, Dahiya R, Kim M, Rosario SR, Lo HC, Yu C, Dai T, Gugala Z, Zhang J, Dasgupta S, Wang H. Differential bone morphology and hypoxia activity in skeletal metastases of ER+ and ER- breast cancer. Commun Biol. 2024 Nov 21;7(1):1545. doi: 10.1038/s42003-024-07247-6. PMID: 39572705; PMCID: PMC11582807.
- Dai T, Rich LJ, Seshadri M, Dasgupta S. Protocol to detect and quantify tumor hypoxia in mice using photoacoustic imaging. STAR Protoc. 2024 Jun 21;5(2):102993. doi: 10.1016/j.xpro.2024.102993. Epub 2024 Apr 2. PMID: 38568814; PMCID: PMC10999710.
- Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, Karri D, Zhu B, Yang F, Coarfa C, O'Malley BW, Yi P. TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2218229120. doi: 10.1073/pnas.2218229120. Epub 2023 May 8. PMID: 37155905; PMCID: PMC10193960.
- Sawant Dessai A, Kalhotra P, Novickis AT, Dasgupta S. Regulation of tumor metabolism by post translational modifications on metabolic enzymes. Cancer Gene Ther. 2023 Apr;30(4):548-558. doi: 10.1038/s41417-022-00521-x. Epub 2022 Aug 23. PMID: 35999357; PMCID: PMC9947196.
- Dai T, Rosario SR, Katsuta E, Sawant Dessai A, Paterson EJ, Novickis AT, Cortes Gomez E, Zhu B, Liu S, Wang H, Abrams SI, Seshadri M, Bshara W, Dasgupta S. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756. PMID: 36476868; PMCID: PMC9807018.
Press Release
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone
- Journal: Cancer Res, January 2021
- Authors: Sawant Dessai A, Dominguez MP, Chen UI, Hasper J, Prechtl C, Yu C, Katsuta E, Dai T, Zhu B, Jung SY, Putluri N, Takabe K, Zhang XH, O'Malley BW, Dasgupta S.
- Citation: Cancer Res. 2021 Jan 1;81(1):50-63. doi: 10.1158/0008-5472.CAN-20-1708.
- Blundon MA, Dasgupta S. Metabolic Dysregulation Controls Endocrine Therapy-Resistant Cancer Recurrence and Metastasis. Endocrinology. 2019 Aug 1;160(8):1811-1820. doi: 10.1210/en.2019-00097. PMID: 31157867; PMCID: PMC6620757.
- Singh R, et al. TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. J Clin Invest. 2018 Jul 2;128(7):3129-3143. doi: 10.1172/JCI96060. Epub 2018 Jun 18. PMID: 29715200; PMCID: PMC6026011.
Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
- Journal: Nature, April 2018
- Authors: Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW.
- Citation: Nature. 2018 Apr;556(7700):249-254. doi: 10.1038/s41586-018-0018-1. Epub 2018 Apr 3. PMID: 29615789; PMCID: PMC5895503.
- Kaushik AK, et al. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016 May 19;7:11612. doi: 10.1038/ncomms11612. PMID: 27194471; PMCID: PMC4874037.
- Nikolai BC, et al. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15;76(6):1463-75. doi: 10.1158/0008-5472.CAN-15-2383. Epub 2016 Feb 1. PMID: 26833126; PMCID: PMC4794399.
- Zhu B, et al. Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading. Mol Cell. 2015 Dec 3;60(5):769-783. doi: 10.1016/j.molcel.2015.10.024. Epub 2015 Nov 21. PMID: 26611104; PMCID: PMC4671835.
Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis
- Journal: JCI, February 2015
- Authors: Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik AK, Arnold JM, Bhowmik SK, Stashi E, Brennan CA, Rajapakshe K, Coarfa C, Mitsiades N, Ittmann MM, Chinnaiyan AM, Sreekumar A, O'Malley BW.
- Citation: J Clin Invest. 2015 Mar 2;125(3):1174-88. doi: 10.1172/JCI76029. Epub 2015 Feb 9. PMID: 25664849; PMCID: PMC4362260.
Contact the Dasgupta Lab
Email: Subhamoy.Dasgupta@RoswellPark.org
Phone: 716-845-2461 or 716-845-2462
Lab Location: Center for Genetics & Pharmacology (CGP) L3-101- 106
Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263