Dai T, Rich LJ, Seshadri M, Dasgupta S. Protocol to detect and quantify tumor hypoxia in mice using photoacoustic imaging. STAR Protoc. 2024 Jun 21;5(2):102993. doi: 10.1016/j.xpro.2024.102993. Epub 2024 Apr 2. PMID: 38568814; PMCID: PMC10999710.
Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, Karri D, Zhu B, Yang F, Coarfa C, O'Malley BW, Yi P. TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2218229120. doi: 10.1073/pnas.2218229120. Epub 2023 May 8. PMID: 37155905; PMCID: PMC10193960.
Sawant Dessai A, Kalhotra P, Novickis AT, Dasgupta S. Regulation of tumor metabolism by post translational modifications on metabolic enzymes. Cancer Gene Ther. 2023 Apr;30(4):548-558. doi: 10.1038/s41417-022-00521-x. Epub 2022 Aug 23. PMID: 35999357; PMCID: PMC9947196.
Dai T, Rosario SR, Katsuta E, Sawant Dessai A, Paterson EJ, Novickis AT, Cortes Gomez E, Zhu B, Liu S, Wang H, Abrams SI, Seshadri M, Bshara W, Dasgupta S. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756. PMID: 36476868; PMCID: PMC9807018.
Sawant Dessai A, et al. Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Cancer Res. 2021 Jan 1;81(1):50-63. doi: 10.1158/0008-5472.CAN-20-1708. Epub 2020 Oct 28. PMID: 33115805; PMCID: PMC7878313.
Blundon MA, Dasgupta S. Metabolic Dysregulation Controls Endocrine Therapy-Resistant Cancer Recurrence and Metastasis. Endocrinology. 2019 Aug 1;160(8):1811-1820. doi: 10.1210/en.2019-00097. PMID: 31157867; PMCID: PMC6620757.
Singh R, et al. TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. J Clin Invest. 2018 Jul 2;128(7):3129-3143. doi: 10.1172/JCI96060. Epub 2018 Jun 18. PMID: 29715200; PMCID: PMC6026011.
Dasgupta S, et al. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 Apr;556(7700):249-254. doi: 10.1038/s41586-018-0018-1. Epub 2018 Apr 3. PMID: 29615789; PMCID: PMC5895503.
Roswell ParkCell Metabolism (2018)Houston Chronicle Baylor College of Medicine
Kaushik AK, et al. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016 May 19;7:11612. doi: 10.1038/ncomms11612. PMID: 27194471; PMCID: PMC4874037.
Nikolai BC, et al. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15;76(6):1463-75. doi: 10.1158/0008-5472.CAN-15-2383. Epub 2016 Feb 1. PMID: 26833126; PMCID: PMC4794399.
Zhu B, et al. Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading. Mol Cell. 2015 Dec 3;60(5):769-783. doi: 10.1016/j.molcel.2015.10.024. Epub 2015 Nov 21. PMID: 26611104; PMCID: PMC4671835.
Dasgupta S, et al. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015 Mar 2;125(3):1174-88. doi: 10.1172/JCI76029. Epub 2015 Feb 9. PMID: 25664849; PMCID: PMC4362260.
Dasgupta S, et al. Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med. 2014;65:279-92. doi: 10.1146/annurev-med-051812-145316. Epub 2013 Sep 16. PMID: 24111892; PMCID: PMC4327818.
Contact the Dasgupta Lab
Email: Subhamoy.Dasgupta@RoswellPark.org
Phone: 716-845-2461 or 716-845-2462
Lab Location: Center for Genetics & Pharmacology (CGP) L3-101- 106
Department of Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263