Epigenetic deregulation in prostate cancer

The Smiraglia Lab studies cancer epigenetics and how disruptions in metabolism, chromatin structure and DNA methylation combine to promote cancer cell ‘evolution’ as they adapt to changing stress.

Lab Research

Research focus

Figure from a scientific research study

How do normal cells determine and maintain their identity? How do those mechanisms become corrupted in cancer to allow cells to adapt to stress? These are the questions driving the Smiraglia Lab.

Our lab has two major research themes:

  • Epigenetic modifications provide an exceptional route for cancer cell ‘evolution’ as cancers progress to advanced phenotypes.
  • Epigenetic regulation is the means by which the genome can be responsive to the environment.

Leveraging polyamine metabolism

The role of NCOR2 in regulating cell identity


Read the research

Funding sources

Contact Information

Connect with the Smiraglia Lab


Department of Cell Stress Biology
Center for Genetics & Pharmacology (CGP) L3-107-110
Roswell Park Comprehensive Cancer Center 
Elm and Carlton Streets 
Buffalo, NY 14263