Epigenetic deregulation in prostate cancer
The Smiraglia Lab studies cancer epigenetics and how disruptions in metabolism, chromatin structure and DNA methylation combine to promote cancer cell ‘evolution’ as they adapt to changing stress.
How do normal cells determine and maintain their identity? How do those mechanisms become corrupted in cancer to allow cells to adapt to stress? These are the questions driving the Smiraglia Lab.
Our lab has two major research themes:
- Epigenetic modifications provide an exceptional route for cancer cell ‘evolution’ as cancers progress to advanced phenotypes.
- Epigenetic regulation is the means by which the genome can be responsive to the environment.