Discoveries made by the Smiraglia Lab have been published in Scientific Reports, Nature Communications, Oncogene, Journal of Clinical Investigation, and other prominent journals. 

Figure from a scientific research study

JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy

  • Journal: Molecular Cancer Research, January 2023
  • Authors: Rosario SR, Jacobi JJ, Long MD, Affronti HC, Rowsam AM, Smiraglia DJ.
  • Citation: Mol Cancer Res. 2023 Jan 3;21(1):24-35. doi: 10.1158/1541-7786.MCR-22-0316.
PubMedFull text
Figure from a scientific research study

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

  • Journal: Cell Reports, December 2021
  • Authors: Long MD, Jacobi JJ, Singh PK, Llimos G, Wani SA, Rowsam AM, Rosario SR, Hoogstraat M, Linder S, Kirk J, Affronti HC, Bergman A, Zwart W, Campbell MJ, Smiraglia DJ
  • Citation: Cell Rep. 2021 Dec 14;37(11):110109. doi: 10.1016/j.celrep.2021.110109.
PubMedFull text
Figure from a scientific research study

Dynamic patterns of DNA methylation in the normal prostate epithelial differentiation program are targets of aberrant methylation in prostate cancer

  • Journal: Scientific Reports, June 2021
  • Authors: Long MD, Dhiman VK, Affronti HC, Hu Q, Liu S, Smiraglia DJ
  • Citation: Sci Rep. 2021 Jun 1;11(1):11405. doi: 10.1038/s41598-021-91037-1.
PubMedFull text
Figure from a scientific research study

Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

  • Journal: Nature Communications, January 2020
  • Authors: Affronti HC, Rowsam AM, Pellerite AJ, Rosario SR, Long MD, Jacobi JJ, Bianchi-Smiraglia A, Boerlin CS, Gillard BM, Karasik E, Foster BA, Moser M, Wilton JH, Attwood K, Nikiforov MA, Azabdaftari G, Pili R, Phillips JG, Casero RA Jr, Smiraglia DJ
  • Citation: Nat Commun. 2020 Jan 7;11(1):52. doi: 10.1038/s41467-019-13950-4
PubMedFull text
Figure from a scientific research study

The miR-96/RARγ signaling axis governs androgen signaling and PCa progression

  • Journal: Oncogene, January 2019
  • Authors: Long MD, Singh PK, Russell JR, Llimos G, Rosario S, Rizvi A, Withers H, van den Berg PB, Kirk J, Sucheston-Campbell LE, Smiraglia DJ, Campbell MJ
  • Citation: Oncogene. 2019 Jan;38(3):421-444. doi: 10.1038/s41388-018-0450-6.
PubMedFull text
Figure from a scientific research study

Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas

  • Journal: Nature Communications, December 2018
  • Authors: Rosario SR, Long MD, Affronti HC, Rowsam AM, Eng KH, Smiraglia DJ
  • Citation: Nat Commun. 2018 Dec 14;9(1):5330. doi: 10.1038/s41467-018-07232-8.
PubMedFull text
Figure from a scientific research study

Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

  • Journal: Journal of Clinical Investigation, October 2018
  • Authors: Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA
  • Citation: J Clin Invest. 2018 Oct 1;128(10):4682-4696. doi: 10.1172/JCI70712.
PubMedFull text

Connect with the Smiraglia Lab


Department of Cell Stress Biology
Center for Genetics & Pharmacology (CGP) L3-107-110
Roswell Park Comprehensive Cancer Center 
Elm and Carlton Streets 
Buffalo, NY 14263