Available Technologies

TAK1 Inhibitors as Anti-Cancer Agents

Transforming Growth Factor- β-Activated Kinase 1(TAK1) inhibition is a 20 mechanism to down-regulate cancer growth. Transforming growth factor-β1 (TGF-β1) cytokine regulates the composition of extracellular matrix (ECM), matrix proteolysis, and inflammatory responses.

HLA Class II Peptide Mimics

The present invention provides peptide mimics for HLA class II antigens. The peptide mimics were identified by panning phage display peptide libraries with anti-HLA class II monoclonal antibodies.

Anti-Idiotypic Peptide Sequences

The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen.

GD3 Peptide Mimics

The invention provides peptide mimics for GD3 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD3 monoclonal antibody.

GD2 Peptide Mimics

The invention provides peptide mimics for GD2 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD2 monoclonal antibody. The identified peptide mimics can be used as immunogens for cancer therapy such as for melanoma and neuroblastoma.

Oncogenic Kinase-Activated Anti-Cancer Therapy

Chronic myeloid leukemia (CML) accounts for approximately 20% of leukemia diagnosed in adults. The hallmark of CML is bcr-abl fusion gene, which arises from the reciprocal chromosomal translocation t(9:22)(q34;q11) resulting in the Philadelphia chromosome.

Anti-Tumor Augmentation for Epithelial Ovarian Cancer

Epithelial ovarian cancer (EOC) is a significant medical problem in the U.S., and in many countries throughout the world. It is typically diagnosed at an advanced stage, and relapse of the disease occurs in the vast majority of patients, with a mean time of about 18 months after primary surgery.

Inventor

Modulation of Hematopoiesis and Inflammatory Cell Production by ST6Gal-1

Hematopoiesis is the mechanism that produces circulating blood cells and certain other cells that participate in immune responses in various tissues. Inflammation is part of a complex of biological responses to harmful stimuli, such as pathogens, damaged cells, irritants, or tissue malfunction.