Available Technologies

Transforming Growth Factor- β-Activated Kinase 1(TAK1) inhibition is a 20 mechanism to down-regulate cancer growth. Transforming growth factor-β1 (TGF-β1) cytokine regulates the composition of extracellular matrix (ECM), matrix proteolysis, and inflammatory responses.

Many surgeries can be broken down into a series of surgical steps, performed in a pre-determined order to accomplish the desired result of the surgery. Each of the surgical steps may correspond with one or more surgical activities.

Peritoneal carcinomatosis is a condition characterized by the presence of multiple cancer nodules throughout the abdominal cavity.

Microscopic features of human tumors have only ever been measured with simple snapshots in time.

Liposomes have been extensively used in the past decade as drug carriers.

Provided are compositions and methods for identifying agents that can modulate expression of the human survivin gene. The compositions include eukaryotic cells that contain a human survivin promoter sequence operably linked to a reporter gene.

Organ-specific toxicity is associated with clinically active chemotherapeutic agents and represents challenging health problems. Alopecia is a toxicity effect of chemotherapy-treated patients with breast cancer.

The invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines.

The present invention provides peptide mimics for HLA class II antigens. The peptide mimics were identified by panning phage display peptide libraries with anti-HLA class II monoclonal antibodies.

Provided in the invention are recombinant peptides and a method for using the peptides in stimulating an immune response against human high molecular weight-melanoma associated antigen (HMW-MAA).

The invention provides a method for increasing the efficacy of antifolates which act via inhibition of dihydrofolate reductase (DHFR).

The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen.

The invention provides peptide mimics for GD3 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD3 monoclonal antibody.

The invention provides peptide mimics for GD2 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD2 monoclonal antibody. The identified peptide mimics can be used as immunogens for cancer therapy such as for melanoma and neuroblastoma.

CD4+ T cells recognize peptide fragments presented on MHC class II (HLA class II in humans).

Hypoxia and decreased supply of nutrients are the hallmarks of kidney ischemia. Hypoxia and ischemia have been implicated in a host of human diseases, including cancer, heart disease, and neurological disorders.

Prostate cancer manifests itself in various degrees of aggressiveness and it is extremely difficult to distinguish between forms to determine prognosis or treatment.

Endoglin is a homodimeric tumor-associated cell membrane antigen that is mainly expressed on leukemia cells and endothelial cells. Endoglin’s expression on endothelial cells is upregulated on proliferating endothelial cells of the tumor-associated vascular and lymphatic endothelium.

The antioxidant Peroxiredoxin 1 (Prx1) is a molecular chaperone that acts as a regulator of hydrogen peroxide signaling, is overexpressed in many cancers, and is often secreted from tumor cells.

Angiogenesis is critical in tumor progression and metastasis in most, if not all, solid tumors; especially since a functional vascular supply is required for the continued growth of solid tumors and the spread of cancer cells.

All aspects of cellular function, including localization, metabolism, proliferation, differentiation, and cell death, among others, involve regulatory proteins that interact and activate specific cellular sensor protein molecules (receptors).

Chronic myeloid leukemia (CML) accounts for approximately 20% of leukemia diagnosed in adults. The hallmark of CML is bcr-abl fusion gene, which arises from the reciprocal chromosomal translocation t(9:22)(q34;q11) resulting in the Philadelphia chromosome.

Anti-folates are antagonists of the action of the folate family of essential human vitamins, all of which are derived from the folic acid structure. The most commonly used antifolate in humans is currently methotrexate (MTX).

Widely recognized that binding between proteins is central to virtually all biological processes.

Gene trapping involves technologies for marking genes by the random integration of DNA sequences containing a detectable reporter (marker). Gene trap technologies provide vectors that typically do not contain a promoter.

Adverse drug reactions (ADR) are a common complication of treatment of a variety of diseases. They cause damage which in many instances is permanent, impairs the quality of life, leads to additional hospitalizations, and frequently also impairs the outcome of treatment.

ErbB2 is an important oncogene and anti-tumor target. ErbB2 gene amplification occurs in 20-30% of human breast cancer and is significantly correlated with protein expression in the cancer tissues.

Epithelial ovarian cancer (EOC) is a significant medical problem in the U.S., and in many countries throughout the world. It is typically diagnosed at an advanced stage, and relapse of the disease occurs in the vast majority of patients, with a mean time of about 18 months after primary surgery.

At present, no commercially available biomarkers have been identified to differentiate between men with and without prostate cancer (CaP), or to differentiate high risk CaP from indolent CaP better than the PSA test.

Bladder cancer is the fourth most common malignancy in men and eighth most common in women. The majority of bladder cancers are detected as superficial without muscle invasion and are treated with transurethral resection. However the rate of recurrence is ~80%.

Malignant gliomas are among the most devastating of all human cancers. Even with aggressive treatment, including surgery, radiation therapy, and chemotherapy survival remains poor.

The chemokine receptor CXCR4 and its cognate ligand, CXCL12 form a pivotal axis for enabling metastasis by many solid tumor types, including head/neck, ovarian, and breast cancers. First, CXCR4 is essential for metastatic spread to organs where CXCL12 is expressed.

Hematopoiesis is the mechanism that produces circulating blood cells and certain other cells that participate in immune responses in various tissues. Inflammation is part of a complex of biological responses to harmful stimuli, such as pathogens, damaged cells, irritants, or tissue malfunction.

By and large, magnetic resonance (MR) contrast media have neither been disease specific nor organ-specific. Injected intravenously, most are rapidly excreted by the kidneys by glomerular filtration.