Available Technologies

Transforming Growth Factor- β-Activated Kinase 1(TAK1) inhibition is a 20 mechanism to down-regulate cancer growth. Transforming growth factor-β1 (TGF-β1) cytokine regulates the composition of extracellular matrix (ECM), matrix proteolysis, and inflammatory responses. TGF-β1 suppresses tumor...

Inventor: Andrei Bakin, PhD, Inventor: Spandan Chennamadhavuni, Inventor: Huw M. L. Davies

Many surgeries can be broken down into a series of surgical steps, performed in a pre-determined order to accomplish the desired result of the surgery. Each of the surgical steps may correspond with one or more surgical activities. For example, a surgical step wherein two anatomical objects are...

Inventor: Khurshid Guru, MD, Inventor: Ashirwad Chowriappa, PhD

Peritoneal carcinomatosis is a condition characterized by the presence of multiple cancer nodules throughout the abdominal cavity. One of the well-known treatments for this condition is the surgical removal of all visible tumors or tumor-studded organs, followed by perfusion of the abdominal...

Inventor: Pragatheeshwar Thirunavukarasu, MD, Inventor: Joseph Skitzki, MD

Microscopic features of human tumors have only ever been measured with simple snapshots in time. Tumors are usually either biopsied or removed and pathologic evaluation includes fixing the specimen and then performing either stains or other types of analysis that cannot measure any dynamic...

Liposomes have been extensively used in the past decade as drug carriers. Desired properties of efficient carriers include the ability to evade the mononuclear phagocyte system (MPS) to prolong the circulation half-life (t1/2), and preferential release of the encapsulated drug at the targeted...

Inventor: Sek-Wen Hui, PhD

Provided are compositions and methods for identifying agents that can modulate expression of the human survivin gene. The compositions include eukaryotic cells that contain a human survivin promoter sequence operably linked to a reporter gene. The method comprises determining whether a test...

Inventor: Fengzhi Li, PhD

Organ-specific toxicity is associated with clinically active chemotherapeutic agents and represents challenging health problems. Alopecia is a toxicity effect of chemotherapy-treated patients with breast cancer. Cyclophosphamide, an important chemotherapeutic agent in the treatment of breast...

The invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines.

The present invention provides peptide mimics for HLA class II antigens. The peptide mimics were identified by panning phage display peptide libraries with anti-HLA class II monoclonal antibodies. The peptide mimics inhibit the binding of an anti-HLA class II antigen antibody to HLA class II...

Inventor: Soldano Ferrone, MD, PhD

Provided in the invention are recombinant peptides and a method for using the peptides in stimulating an immune response against human high molecular weight-melanoma associated antigen (HMW-MAA). The peptides were designed from the identification of regions of structural and amino acid sequence...

Inventor: Soldano Ferrone, MD, PhD

The invention provides a method for increasing the efficacy of antifolates which act via inhibition of dihydrofolate reductase (DHFR). The method comprises the steps of administration of 5-amino-4-imidazolecarboxamide riboside (Z) or its base with the antifolate such that the targeted cells are...

The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino acid...

Inventor: Soldano Ferrone, MD, PhD

The invention provides peptide mimics for GD3 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD3 monoclonal antibody. The peptide mimics inhibit the binding of an anti-GD3 antibody to GD3 positive cells and also elicit antibodies which can...

Inventor: Soldano Ferrone, MD, PhD

The invention provides peptide mimics for GD2 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD2 monoclonal antibody. The identified peptide mimics can be used as immunogens for cancer therapy such as for melanoma and neuroblastoma.

Inventor: Soldano Ferrone, MD, PhD

CD4+ T cells recognize peptide fragments presented on MHC class II (HLA class II in humans). In addition to antigen-presenting cells such as macrophages and dendritic cells, many human cancer cells express MHC class II constitutively or in an IFN-γ-inducible manner although the role of MHC class...

Hypoxia and decreased supply of nutrients are the hallmarks of kidney ischemia. Hypoxia and ischemia have been implicated in a host of human diseases, including cancer, heart disease, and neurological disorders. Additionally, organs and tissues which are obtained for transplantation frequently...

Prostate cancer manifests itself in various degrees of aggressiveness and it is extremely difficult to distinguish between forms to determine prognosis or treatment. The advent of a reliable biomarker to stratify prostate cancer patients by the aggressiveness of their disease or indicate novel...

Endoglin is a homodimeric tumor-associated cell membrane antigen that is mainly expressed on leukemia cells and endothelial cells. Endoglin’s expression on endothelial cells is upregulated on proliferating endothelial cells of the tumor-associated vascular and lymphatic endothelium. Endoglin is...

Inventor: Ben Seon, PhD

The antioxidant Peroxiredoxin 1 (Prx1) is a molecular chaperone that acts as a regulator of hydrogen peroxide signaling, is overexpressed in many cancers, and is often secreted from tumor cells. Prx1 expression is elevated in various cancers, including esophageal, pancreatic, lung, follicular...

Angiogenesis is critical in tumor progression and metastasis in most, if not all, solid tumors; especially since a functional vascular supply is required for the continued growth of solid tumors and the spread of cancer cells. Small non-growing tumors may remain dormant for years and the...

All aspects of cellular function, including localization, metabolism, proliferation, differentiation, and cell death, among others, involve regulatory proteins that interact and activate specific cellular sensor protein molecules (receptors). The vast majority of cellular control mechanisms...

Chronic myeloid leukemia (CML) accounts for approximately 20% of leukemia diagnosed in adults. The hallmark of CML is bcr-abl fusion gene, which arises from the reciprocal chromosomal translocation t(9:22)(q34;q11) resulting in the Philadelphia chromosome. The Bcr-Abl fusion protein exhibits...

Anti-folates are antagonists of the action of the folate family of essential human vitamins, all of which are derived from the folic acid structure. The most commonly used antifolate in humans is currently methotrexate (MTX). MTX is used to treat a number of pathological conditions, including...

Widely recognized that binding between proteins is central to virtually all biological processes. With several completed genome sequences as a framework with which to interpret such interactions, several large scale projects have attempted to define protein interactions for all of the open...

Gene trapping involves technologies for marking genes by the random integration of DNA sequences containing a detectable reporter (marker). Gene trap technologies provide vectors that typically do not contain a promoter. Instead, gene trap vectors provide specific sequences that generate fusion...

Adverse drug reactions (ADR) are a common complication of treatment of a variety of diseases. They cause damage which in many instances is permanent, impairs the quality of life, leads to additional hospitalizations, and frequently also impairs the outcome of treatment. In a number of instances...

ErbB2 is an important oncogene and anti-tumor target. ErbB2 gene amplification occurs in 20-30% of human breast cancer and is significantly correlated with protein expression in the cancer tissues. ErbB2 amplification or overexpression also occurs in other cancers, e.g., gastric cancer and...

Epithelial ovarian cancer (EOC) is a significant medical problem in the U.S., and in many countries throughout the world. It is typically diagnosed at an advanced stage, and relapse of the disease occurs in the vast majority of patients, with a mean time of about 18 months after primary surgery...

Inventor: Brahm Segal, MD

At present, no commercially available biomarkers have been identified to differentiate between men with and without prostate cancer (CaP), or to differentiate high risk CaP from indolent CaP better than the PSA test. The widespread use of PSA testing has resulted in 1.3 million additional men...

Bladder cancer is the fourth most common malignancy in men and eighth most common in women. The majority of bladder cancers are detected as superficial without muscle invasion and are treated with transurethral resection. However the rate of recurrence is ~80%. Currently, patients who are at...

Inventor: Yuesheng Zhang, MD, PhD, Inventor: Arup Bhattacharya, PhD, Inventor: Li Tang, PhD, Inventor: Yun Li, Inventor: Joseph Paonessa, Inventor: Feng Geng, Inventor: Yi Ding

Malignant gliomas are among the most devastating of all human cancers. Even with aggressive treatment, including surgery, radiation therapy, and chemotherapy survival remains poor. Survivin is a tumor-associated antigen that is highly expressed in many cancers and is associated with chemotherapy...

The chemokine receptor CXCR4 and its cognate ligand, CXCL12 form a pivotal axis for enabling metastasis by many solid tumor types, including head/neck, ovarian, and breast cancers. First, CXCR4 is essential for metastatic spread to organs where CXCL12 is expressed. Second, CXCL12 can stimulate...

Hematopoiesis is the mechanism that produces circulating blood cells and certain other cells that participate in immune responses in various tissues. Inflammation is part of a complex of biological responses to harmful stimuli, such as pathogens, damaged cells, irritants, or tissue malfunction....

By and large, magnetic resonance (MR) contrast media have neither been disease specific nor organ-specific. Injected intravenously, most are rapidly excreted by the kidneys by glomerular filtration. Although several liver-specific contrast media have been created, other organs have not been...