Andrei Bakin Andrei Bakin, PhD

Andrei Bakin

PhD

Special Interests:

Epithelial-Mesenchymal Transition and metastasis Tumor-Associated Fibroblasts in Breast cancer microenvironment Ribosome Biogenesis and cancer genetics Novel therapeutics against metastatic cancer

About Andrei Bakin

Biography:

Dr. Bakin graduated with honors from Moscow Lomonosov University and received his PhD in Molecular Biology from Moscow Lomonosov University. He received postdoctoral training in oncogenes with Dr. Tom Curran at St. Jude Children’s Hospital and breast cancer biology with Dr. Carlos Arteaga at Vanderbilt University. Dr. Bakin has done pioneering research in the field of epithelial-mesenchymal transition and breast cancer metastasis. His work contributed to better understanding of basic principles of ribosome biogenesis. Dr. Bakin has significant experience in signal transduction, genome-wide expression and proteomics research. His research involves orthotopic and bone metastasis models of breast cancer.

Positions

Roswell Park Comprehensive Cancer Center
  • Associate Professor of Oncology
  • Department of Cancer Genetics and Genomics

Background

Education and Training:

  • PhD — Molecular Biology, Moscow Lomonosov University, Moscow, Russia
  • MSc — Bioorganic Chemistry, Moscow Lomonosov University, Moscow, Russia

Professional Memberships:

  • Member, American Association for Cancer Research
  • Member, American Society for Cell Biology
  • Member, Metastasis Research Society
  • Editorial Board Member, World Journal of Biological Chemistry
  • Editorial Board Member, MOJ Tumor Research
  • Editorial Board Member, Research Reports

Research

Research Overview:

My current research program includes two major projects elucidating a) the tumor-fibroblast crosstalk in the breast carcinoma microenvironment with a special focus on tumor angiogenesis and metastasis; b) the contribution of ribosome biogenesis in cancer initiation and progression.

Our group investigates how tumor-fibroblast crosstalk affects tumor vascularization and infiltration by pro-tumorigenic immune cells. This collaborative project involves breast pathologist Dr. Alexander Truskinovsky, immunologist Dr. Scott Abrams, and bioinformatician Dr. Song Liu. In the proteomics analysis of tumor-fibroblast interactions, we collaborate with Dr. Paul Wallace, Department of Flow and Image Cytometry.

The ribosome project examines cancer-driven mechanisms of ribosome biogenesis and ribosome-associated nucleolar stress. This project is funded by Breakthrough Award from the Department of Defense, Breast Cancer Research Program. The project explores new therapeutics and treatment strategies for breast cancer patients, including patients with metastatic disease.

Dr. Bakin mentored six postdoctoral trainees, nine graduate students, as well as sixteen undergraduate students. One of his postdoctoral trainees is now a tenured Associate Professor and his former graduate student is a tenure-track faculty.

*Currently accepting students in MSc and PhD programs


Publications