Andrei Bakin

PhD

Special Interests:

Tumore Microenvironment and Metastasis Epithelial-Mesenchymal Transition (EMT) Novel therapeutic Strategies Exploiting Dysregulation in DNA repair Cancer Genetics and Ribosome Biogenesis

About Andrei Bakin

Biography:

Dr. Bakin graduated with honors from Moscow Lomonosov University and received his PhD in Molecular Biology from Moscow Lomonosov University. He received postdoctoral training in oncogenes with Dr. Tom Curran at St. Jude Children's Hospital and in breast cancer biology with Dr. Carlos Arteaga at Vanderbilt University. Dr. Bakin has done pioneering research in the field of epithelial-mesenchymal transition and metastasis. His work contributed to better understanding of ribosome biogenesis. Dr. Bakin has significant experience in signal transduction, gene expression and proteomics. His research involves preclinical breast and pancreatic cancer models.

Positions

Roswell Park Comprehensive Cancer Center

  • Associate Professor of Oncology
  • Department of Cancer Genetics and Genomics

Background

Education and Training:

  • PhD — Molecular Biology, Moscow Lomonosov University, Moscow, Russia
  • MSc — Bioorganic Chemistry, Moscow Lomonosov University, Moscow, Russia

Professional Memberships:

  • Member, American Association for Cancer Research
  • Member, American Society for Cell Biology
  • Member, Metastasis Research Society
  • Editorial Board Member, World Journal of Biological Chemistry
  • Editorial Board Member, MOJ Tumor Research
  • Editorial Board Member, Research Reports
  • Member, Cancer Microenvironment Society

Research

Research Overview:

Current program explores two research directions: a) how the tumor-stroma crosstalk promotes tumor angiogenesis and immune suppressive microenvironment; b) exploits dysregulation in DNA repair for innovative treatment strategies.

Our group identified specific molecular pathways activated by the tumor-fibroblast crosstalk that stimulate tumor vasculature and metastasis, in part through mobilization of pro-tumor immune cells. This project is a collaborative effort with Dr. Scott Abrams (Department of Immunology). The proteomics aspect of this research is investigated in collaboration with Dr. Paul Wallace, Department of Flow and Image Cytometry.

Our group explores a dysregulation in DNA repair for selective poisoning of tumor cells carrying mutant p53, including breast, gastric and pancreatic cancers. The goal is to translate our basic research findings into clinical applications. This project involves basic science researchers and clinicians. Important outcome of our research is the first-in-human Phase 1 clinical trail directed by Dr. Christos Fountzillas.

Dr. Bakin mentored six postdoctoral trainees, ten graduate students, and over twenty undergraduate students. One of his postdoctoral trainees is now a tenured Associate Professor and his former graduate students occupy tenure-track faculty positions.

*Currently accepting students in MSc and PhD programs


Publications