- Nodular sclerosing Hodgkin lymphoma (NSCHL). The most common type of Hodgkin disease, NSCHL usually begins in lymph nodes in the chest or neck. It occurs mostly in teenagers and young adults.
- Mixed cellularity Hodgkin lymphoma (MCCHL) usually begins in the upper body. It affects mostly people who are HIV-positive, but it can occur in children and older people.
- Lymphocyte-rich Hodgkin lymphoma usually begins in the upper body, but it tends to be present in only a few lymph nodes.
- Lymphocyte-depleted Hodgkin lymphoma usually begins in the abdomen or in the bone marrow, liver or spleen. It affects mostly the elderly and people who are HIV-positive. It tends to be diagnosed in the late stages.
Classic Hodgkin lymphoma treatment options
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)
Five percent of Hodgkin lymphoma cases fall into the category of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). It usually begins in lymph nodes under the arm or in the neck.
It’s identified by the presence of large lymphocytic and histiocytic (L&H) cells, which are sometimes called “popcorn cells” because of their shape. It grows more slowly than classic Hodgkin lymphoma.
NLPHL is treated differently from classic Hodgkin lymphomas, usually with agents commonly used to treat slow-growing forms of NHL.