Roswell Park - UPCI Ovarian Cancer SPORE Projects

Project 1

"Inhibition of indole-amine 2,3 dioxygenase to enhance ovarian tumor immunity"

Co-Leaders: Kunle Odunsi, MD, PhD; Protul Shrikant, PhD

This project will test a novel therapeutic strategy to break indoleamine 2,3-dioxygenase (IDO)-mediated immune tolerance in ovarian cancer, while inducing anti-tumor-specific immunity in ovarian cancer patients in second remission.

Project 2

“Rapamycin and IL-21 conditioned CD8+ T cells for adoptive cellular therapy of ovarian cancer”

Co-Leaders: Cassian Yee, MD, PhD; Protul Shrikant, PhD; Kunle Odunsi, MD, PhD

This project will test a combinatorial strategy of mTOR inhibiton and IL-21 for ex-vivo conditioning of antigen stimulated CD8+ T cells for effector and memory functional attributes; and test whether the ex-vivo generated cells produce durable immunity against ovarian tumors in a clinical trial.

Project 3

“MHC-Restricted and MHC-Non-Restricted Targeting of Ovarian Cancer byαDC1-induced CTLs”

Co-Leaders: Robert Edwards, MD; Pawel Kalinski, MD, PhD

This project will test whether autologous tumor-loaded type-1-polarized dendritic cells (αDC1s) will generate CTLs capable of recognizing ovarian cancer in either MHC class I-restricted-or MHC class I-unrestricted fashion; when used both as a vaccine and for adoptive T cell therapy.

Project 4

“Myeloid derived suppressor cells in ovarian carcinogenesis”

Co-Leaders: Kirsten Moysich, PhD; Lara Sucheston-Campbell, PhD; Shashikant Lele, MD

This project will determine the predictive significance of myeloid derived suppressor cells (MDSCs), which have strong immunosuppressive properties in the long-term survival of ovarian cancer patients.