Exploring cancer genomics

As a computational biologist, my research focuses on understanding the mechanisms of cancer initiation, progression, and prognosis through developing and utilizing computational methods.

My recent research areas include:

  • Identifying driver mutation, etiology, mechanism, and heterogeneity in human and mouse cancer genomes
  • Ultra-sensitive detection of cancerous and precancerous lesions using somatic mutations
  • Developing innovative and integrative open-source computational software for analyzing genomics data
  • Accurately interpreting complex genomic variants by haplotype-aware annotations
Lab Research

Current research

Cancer genomics & tumor evolution

Next-generation sequencing (NGS) has become widely accessible in research and clinical laboratories. By using whole-genome, whole-exome and transcriptomes sequencing, we can detect various types of variants.

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Ultra-sensitive detection of mutations in tumor and normal tissues

We’ve conducted innovative studies aiming to expand our detection limits to very-low-frequency (<5%) mutations, which are important for cancer early detection and residual disease monitoring.

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Tumor-specific neoantigents for immunoprofiling

We designed the Christmas Light Plot (CLP) for easy visualization of identified neoantigens. The CLP incorporates pre-defined criteria for neoantigen prioritization.

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Mutational landscapes in preclinical models

Analyses of mouse somatic mutations pose a unique challenge due to the diverse genetic background in GEM and mouse stromal contamination in PDX models.

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Find download links for Dr. Wei’s code on GitHub.

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Bioinformatics Shared Resource

Dr. Wei is co-director of this core science facility.

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The Wei Lab team

Our lab is staffed by the best and brightest.

Meet Our Team
Contact Information

Contact the Wei Lab

Email: Lei.Wei@RoswellPark.org
Phone: 716-845-1176
Office location: Research Studies Center (RSC) - R-448B
Lab location: Research Studies Center (RSC) 4th floor

Department of Biostatistics and Bioinformatics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263