Positions
Roswell Park Comprehensive Cancer Center
- Associate Professor of Oncology
- Co-Director, Bioinformatics Core Resource
- Department of Biostatistics and Bioinformatics
Background
Education and Training
- PhD - State University of New York at Buffalo
- BS - University of Science and Technology of China
Fellowship
- Postdoctoral Fellow - St. Jude Children's Research Hospital
Research Overview
Dr. Wei is an R01-funded computational biologist. His researches focus on developing and utilizing integrative computational algorithms to understand cancer genomics and other biological questions. Dr. Wei's current research areas include:
- Ultra-sensitive detection of cancerous and precancerous lesions using somatic mutations.
- Accurate interpretation of complex genomic variants by haplotype-aware annotations.
- Identify driver mutation, etiology, mechanism, and heterogeneity in human & mouse cancer genomes.
- Develop innovative and integrative open-source computational software for cancer genomics.
Publications
Yao S*, Wei L*, Hu Q*, Liu S*, Manojlovic Z, Fiorica PN, Long M, Zirpoli GR, Cai Q, Long J, Ping J, Barnard ME, Jin Y, Murakami M, Wang J, Zhu Q, Davis W, Chen J, Ondracek RP, Khoury T, Gandhi S, Takabe K, Ko N, Sanderson M, Hong CC, Bandera EV, Craig DW, Ambrosone CB, Palmer JR, Zheng W, Carpten JD. Mutational landscape of triple-negative breast cancer in African American women. Nature Genetics. 2025 Sep;57(9):2166-2176. doi: 10.1038/s41588-025-02322-y. Epub 2025 Aug 26. PMID: 40858906
Wei L§, Fitzgerald ME, Yan L, Murakami M, Grant SR, Hu Q, Fan S, Okai B, Goyal D, Singh PK, Shafirstein G, Remenyik E, Gellen E, Foster BA§, Huss WJ§, Paragh G§. Photodynamic therapy reduces the burden of small ultraviolet-induced epidermal clones in human and mouse skin. Br J Dermatol. 2024 Aug 27:ljae314. doi: 10.1093/bjd/ljae314. PMID: 39189591
Grant SR, Rosario SR, Patentreger AD, Shary Nico, Fitzgerald ME, Singh PK, Foster BA, Huss WJ, Wei L, Paragh G. HotSPOT: A Computational Tool to Design Targeted Sequencing Panels to Assess Early Photocarcinogenesis. Cancers. 2023, 15(5), 1612; https://doi.org/10.3390/cancers15051612
Merz M*, Merz A*, Wang J*, Wei L*, Hu Q, Hutson N, Rondeau C, Celotto K, Belal A, Alberico R, Block AW, Mohammadpour H, Wallace PK, Tario J, Luce J, Glenn SJ, Singh P, Herr MM, Hahn T, Liu S, McCarthy PL, Hillengass J. Deciphering spatial heterogeneity at a single cell resolution in multiple myeloma. Nature Communications.2022 Feb 10;13(1):807. doi: 10.1038/s41467-022-28266-z. PMID: 35145077
Hutson N, Zhan F, Graham J, Murakami M, Zhang H, Ganaparti S, Hu Q, Yan L, Ma C, Liu S, Xie J§, Wei L§. An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing. BMC Medical Genomics. 2021 Dec 2;14(Suppl 2):32. doi: 10.1186/s12920-021-00880-8. PMID: 34856988
Wei L*§, Christensen S*, Fitzgerald M, Graham J, Hutson N, Zhang C, Huang Z, Hu Q, Zhan F, Xie J, Zhang J, Liu S, Remenyik E, Gellen E, Colegio O, Lin H, Bax M, Xu J, Huss WJ, Foster BA, Paragh G§. Ultra-deep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden. Science Advances.2021 Jan; Vol. 7, no. 1; DOI: 10.1126/sciadv.abd7703. PMID: 33523857.
Wei L*, Hussein AA*, Ma Y*, Azabdaftari G, Ahmed Y, Wong LP, Hu Q, Luo W, Cranwell VN, Bunch BL, Kozlowski JD, Singh PK, Glenn ST, Smith G, Johnson CS, Liu S, Guru KA. Accurate quantification of residual cancer cells in pelvic washing reveals association with cancer recurrence following robot-assisted radical cystectomy. Journal of Urology. 2019 Jun;201(6):1105-1114. doi: 10.1097/JU.0000000000000142.
Huss WJ, Hu Q, Glenn ST, Gangavarapu KJ, Wang J, Luce JD, Quinn PK, Brese EA, Zhan F, Conroy JM, Paragh G, Foster BA, Morrison CD, Liu S, Wei L. Comparison of SureSelect and Nextera exome capture performance in single-cell sequencing. Human Heredity. 2018;83(3):153-162.
Wei L*, Wang J*, Lampert E, Schlanger S, DePriest AD, Hu Q, Gomez EC, Murakami M, Glenn ST, Conroy J, Morrison C, Azabdaftari G, Mohler JL, Liu S, Heemers HV. Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators. European Urology. 2017 Feb;71(2):183-192.
Wei L*§, Liu LT*, Conroy JR, Hu Q, Conroy JM, Morrison CD, Johnson CS, Wang J, Liu S§. MAC: identifying and correcting annotation for multi-nucleotide variations. BMC Genomics. 2015 Aug 1;16:569.
Holmfeldt L*, Wei L*, Diaz-Flores E, Walsh M, Zhang J, Ding L, Payne-Turner D, Churchman M, Andersson A, Chen SC, McCastlain K, Becksfort J, Ma J, Wu G, Patel SN, Heatley SL, Phillips LA, Song G, Easton J, Parker M, Chen X, Rusch M, Boggs K, Vadodaria B, Hedlund E, Drenberg C, Baker S, Pei D, Cheng C, Huether R, Lu C, Fulton RS, Fulton LL, Tabib Y, Dooling DJ, Ochoa K, Minden M, Lewis ID, To LB, Marlton P, Roberts AW, Raca G, Stock W, Neale G, Drexler HG, Dickins RA, Ellison DW, Shurtleff SA, Pui CH, Ribeiro RC, Devidas M, Carroll AJ, Heerema NA, Wood B, Borowitz MJ, Gastier-Foster JM, Raimondi SC, Mardis ER, Wilson RK, Downing JR, Hunger SP, Loh ML, Mullighan CG. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nature Genetics. 2013 Mar;45(3):242-52.