Understanding ovarian cancer
The McLean Laboratory is investigating why ovarian cancers grow and spread, with the goal of identifying new treatment approaches that can ultimately be translated to new options for patients. Additionally, our ongoing collaborative projects focus on optimizing quality of life for ovarian cancer patients both during and after active treatment.
I believe that translational research is the path by which we advance care and outcomes for our ovarian cancer patients, while concurrently training the next generation of investigators.Karen McLean, MD, PhD, FACOG
Areas of ovarian cancer research focus in the McLean laboratory include:
- The impact of DNA damage repair inhibitors on immune response
- Optimizing the efficacy of antiestrogen therapies through novel combinations with additional targeted agents
- Understanding biological stress parameters in survivorship and how they impact clinical outcomes
To carry out these studies, we use established cell lines and animal models, as well as patient-derived samples.
You’ll find research from the McLean laboratory in Journal of the National Cancer Institute, Gynecologic Oncology, Oncogene, Neoplasia and other cancer journals.See the science
Our team is collaborative and highly motivated. Dr. McLean highly values teaching and mentorship, helping each trainee reach the next step in their personal career goals.Meet our team
The McLean laboratory is always looking for the best and brightest cancer scientists for post-doc, graduate trainee and undergraduate research roles.Careers at Roswell Park
World-renowned research hub
The McLean laboratory is an integral part of Roswell Park’s multidisciplinary focus on bench-to-bedside breakthroughs in curing ovarian cancer. Dr. McLean and team work closely with colleagues across campus and across the country: