Hai Wang Lab

Metabolic reprograming in osteoblastic metastasis of prostate cancer

We aim to identify critical mechanisms that support the metabolic adaptation and metastatic progression of prostate cancer cells in bone colonization, thereby allowing prostate cancer cells to survive amidst a limited nutrition supply and environmental stresses in the bone milieu.

Dynamic alteration of metabolism in breast cancer bone metastasis

We hypothesize that the metabolic behaviors may keep changing with the evolution of the metastatic niche and epigenetic reprograming in the development of breast cancer bone metastases; blockades of such metabolic shifting steps may arrest bone metastases progression and prevent their secondary dissemination to other organs.

New models to study bone metastasis

Our research aims to optimize the methodologies and technologies to model bone metastases in order to discover novel mechanisms and medicine strategies for the treatment of skeletal related complications incurred by bone metastases.