Research articles from the Hai Wang Lab can be found in Cell, Cancer Cell, Molecular Cell, Nature Communications, Science Advances, Molecular Cancer Therapy, and other high-impact journals.
Optimization and characterization of a bone culture model to study prostate cancer bone metastasis
- Journal: Molecular Cancer Therapy, August 2022
- Authors: Wu YH, Gugala Z, Barry MM, Shen Y, Dasgupta S, Wang H.
- Citation: Mol Cancer Ther. 2022 Aug 2;21(8):1360-1368. doi: 10.1158/1535-7163.MCT-21-0684
- Dai T, et al. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756.
- Zhang W, et al. The bone microenvironment invigorates metastatic seeds for further dissemination. Cell. 2021 Apr 29;184(9):2471-2486.e20. doi: 10.1016/j.cell.2021.03.011. Epub 2021 Apr 19.
- Bado IL, et al. The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells. Dev Cell. 2021 Apr 19;56(8):1100-1117.e9. doi: 10.1016/j.devcel.2021.03.008.
- Wang H, et al. Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Nat Commun. 2017 Apr 21;8:15045. doi: 10.1038/ncomms15045.
- Wang H, et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells Cancer Cell. 2015 Feb 9;27(2):193-210. doi: 10.1016/j.ccell.2014.11.017. Epub 2015 Jan 15.
- Tian L, et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017 Apr 13;544(7649):250-254. doi: 10.1038/nature21724. Epub 2017 Apr 3
- Welte T, et al. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 Jun;18(6):632-44. doi: 10.1038/ncb3355. Epub 2016 May 16. PubMed PMID: 27183469; PubMed Central PMCID: PMC4884142.
- Wang H, Yu C, Zhang XH. Devil's Wake: Early-stage bone colonization by breast cancer. Mol Cell Oncol. 2016 May;3(3):e1026526. doi: 10.1080/23723556.2015.1026526. eCollection 2016 May.
Contact the Wang Lab
Email: Hai.Wang@RoswellPark.org
Lab Location: Medical Research Complex - Room 358
Department of Molecular and Cellular Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263