Research articles from the Hai Wang Lab can be found in Cell, Cancer Cell, Molecular Cell, Nature Communications, Science Advances, Molecular Cancer Therapy, and other high-impact journals.
Optimization and characterization of a bone culture model to study prostate cancer bone metastasis
- Journal: Molecular Cancer Therapy, August 2022
- Authors: Wu YH, Gugala Z, Barry MM, Shen Y, Dasgupta S, Wang H.
- Citation: Mol Cancer Ther. 2022 Aug 2;21(8):1360-1368. doi: 10.1158/1535-7163.MCT-21-0684
- Liu F, Ding Y, Xu Z, Hao X, Pan T, Miles G, Wang S, Wu YH, Liu J, Bado IL, Zhang W, Wu L, Gao Y, Yu L, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Shen Y, Hoffman D, Becerra Dominguez L, Rivas CH, Chen X, Wang H, Gugala Z, Satcher RL, Zhang XH. Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization. Cell Genom. 2025 Jul 9;5(7):100888. doi: 10.1016/j.xgen.2025.100888. Epub 2025 May 23. PMID: 40412393; PMCID: PMC12278635.
- Das A, Barry MM, Ernst CA, Dahiya R, Kim M, Rosario SR, Lo HC, Yu C, Dai T, Gugala Z, Zhang J, Dasgupta S, Wang H. Differential bone morphology and hypoxia activity in skeletal metastases of ER+ and ER- breast cancer. Commun Biol. 2024 Nov 21;7(1):1545. doi: 10.1038/s42003-024-07247-6. PMID: 39572705; PMCID: PMC11582807.
- Zhao Y, Ning J, Teng H, Deng Y, Sheldon M, Shi L, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L. Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis. Nat Commun. 2024 Mar 16;15(1):2384. doi: 10.1038/s41467-024-46602-3. Erratum in: Nat Commun. 2024 Jun 10;15(1):4937. doi: 10.1038/s41467-024-49356-0. PMID: 38493144; PMCID: PMC10944492.
- Zhang W, Xu Z, Hao X, He T, Li J, Shen Y, Liu K, Gao Y, Liu J, Edwards DG, Muscarella AM, Wu L, Yu L, Xu L, Chen X, Wu YH, Bado IL, Ding Y, Aguirre S, Wang H, Gugala Z, Satcher RL, Wong STC, Zhang XH. Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells. Cancer Discov. 2023 Feb 6;13(2):474-495. doi: 10.1158/2159-8290.CD-22-0220. PMID: 36287038; PMCID: PMC9905315.
- Dai T, et al. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756.
- Zhang W, et al. The bone microenvironment invigorates metastatic seeds for further dissemination. Cell. 2021 Apr 29;184(9):2471-2486.e20. doi: 10.1016/j.cell.2021.03.011. Epub 2021 Apr 19.
- Bado IL, et al. The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells. Dev Cell. 2021 Apr 19;56(8):1100-1117.e9. doi: 10.1016/j.devcel.2021.03.008.
- Wang H, et al. Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Nat Commun. 2017 Apr 21;8:15045. doi: 10.1038/ncomms15045.
- Wang H, et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells Cancer Cell. 2015 Feb 9;27(2):193-210. doi: 10.1016/j.ccell.2014.11.017. Epub 2015 Jan 15.
- Tian L, et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017 Apr 13;544(7649):250-254. doi: 10.1038/nature21724. Epub 2017 Apr 3
- Welte T, et al. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 Jun;18(6):632-44. doi: 10.1038/ncb3355. Epub 2016 May 16. PubMed PMID: 27183469; PubMed Central PMCID: PMC4884142.
- Wang H, Yu C, Zhang XH. Devil's Wake: Early-stage bone colonization by breast cancer. Mol Cell Oncol. 2016 May;3(3):e1026526. doi: 10.1080/23723556.2015.1026526. eCollection 2016 May.
Contact the Wang Lab
Email: Hai.Wang@RoswellPark.org
Lab Location: Medical Research Complex - Room 358
Department of Molecular and Cellular Biology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263