Sai Yendamuri, MD, MBA, FACS

Specialty: Thoracic Surgery
Chief Strategy Officer
Senior Vice President of Strategy, Business Development and Outreach
Director, Thoracic Surgery Laboratory
Chair, Department of Thoracic Surgery
President and CEO, RPCI Oncology, P.C.

 Request an Appointment
Locations

Roswell Park Main Campus
1-800-ROSWELL (1-800-767-9355)

Dr. Yendamuri is a Buffalo Spree Top Doctor! Top Doctors 2025 See all of our physicians who made this year's list.

Cancers Treated:

Carcinoid Esophageal Lung Mediastinal Mesothelioma Neuroendocrine Tumors Thymus

Specializing In:

  • Minimally invasive thoracic surgery
  • Esophageal cancer
  • Complex esophageal surgery for benign esophageal pathology
  • Lung cancer
  • Complex lung surgery for benign lung pathology
  • Mesothelioma
  • Mediastinal tumors
  • Tracheal surgery
  • Photodynamic therapy

Research Interests:

  • Molecular staging of thoracic malignancies
  • Lung cancer screening
  • Risk prediction using genomic markers
  • Global thoracic surgical training

Positions

Roswell Park Comprehensive Cancer Center

  • Chief Strategy Officer
  • Senior Vice President of Strategy, Business Development and Outreach
  • Professor of Oncology
  • Director, Thoracic Surgery Laboratory
  • Chair – Department of Thoracic Surgery
  • Department of Immunology

Roswell Park Care Network

  • President and CEO, RPCI Oncology, P.C.

Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo

  • Professor of Surgery

Background

Education and Training

  • MD - All India Institute of Medical Sciences, New Delhi, India

Residency

  • MD Anderson Cancer Center, Houston, TX
  • New York Hospital Medical Center of Queens/Cornell University, New York, NY
  • Christiana Care Health System, Newark, DE

Fellowship

  • Harrison Department of Surgical Research, Philadelphia, PA
  • Barnes Jewish Hospital, St. Louis, MO

Board Certification

  • American Board of Surgery
Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer
Learn More
Respiratory Muscle Training Before Surgery in Preventing Lung Complications in Patients With Stage I-IIIB Lung Cancer
Learn More

Clinical Trials

Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer
Learn More
Respiratory Muscle Training Before Surgery in Preventing Lung Complications in Patients With Stage I-IIIB Lung Cancer
Learn More
Diabetes drug appears to fight lung cancer — but only in overweight or obese patients Stage 3 esophageal cancer: J.T.’s story Donations bring cutting-edge robotic bronchoscopy to Roswell Park Robotic bronchoscopy offers patients a head start against lung cancer Frequently Searched Questions | Lung Cancer What Does Lung Cancer Feel Like? Four-Time Liver Cancer Survivor: Ronald's Story New Techniques Replace the Chamberlain Procedure What to Expect from Lung Cancer Surgery Meet the Team: Dr. Sai Yendamuri

Featured on CancerTalk

Diabetes drug appears to fight lung cancer — but only in overweight or obese patients
Dr. Sai Yendamuri headshot with Innovation Engine banner in the right corner
Stage 3 esophageal cancer: J.T.’s story
Photo of JT marking off completed treatments on his white board
Donations bring cutting-edge robotic bronchoscopy to Roswell Park
The Monarch system uses a handheld console (seen here), plus computer assisted navigation for robotic bronchoscopy

Showing all3 of 10

Publications

  Full Publications list on PubMed
  • Yendamuri S. Massive Airway Hemorrhage. Thorac Surg Clin 2015 Aug; 25(3):255-60.
  • Patnaik SK, Yendamuri S, Mallick R, Dhillon SS. Reply to “MiR-205 and miR-375 microRNA Assays to Distinguish Squamous Cell Carcinoma From Adenocarcinoma in Lung Cancer Biopsies”. J Thor Oncol. 2015 Jun; 10(6):e53.
  • Hennon MW, Dexter EU, Huang M, Kane J, Nwogu, Picone A, Yendamuri S, Demmy TL. Does Thoracoscopic Surgery Decrease the Morbidity of Combined Lung and Chest Wall Resection. Ann Thor Surg. 2015 Jun; 99(6) 1929-34.
  • Patnaik S, Mallick R, Kannisto E, Sharma R, Bshara W, Yendamuri S, Dhillon SS. MiR-205 and MiR-375 MicroRNA Assays to Distinguish Squamous Cell Carcinoma from Adenocarcinoma in Lung Cancer Biopsies. J Thorac Oncol 2015 Mar; 10(3): 446-53.
  • Dhillon SS, Yendamuri S, Harris K, Roche C, Pokharel S. Lymphangioma Presenting as Hemoptysis in Pregnancy. Am J Respir Crit Care Med 2014 Sept 15; 190(6): 701-3.
  • Battoo A, Jahan A, Yang Z, Nwogu C, Yendamuri S, Dexter E, Hennon M, Picone A, Demmy T. Thoracoscopic Pneumonectomy An 11-Year Experience. Chest 2014; 146(5) 1300-9.
  • Yendamuri S. Invited Commentary. Ann Thorac Surg 2014; 97(3): 986.
  • Nurkin SJ, Nava HR, Yendamuri S, LeVea CM, Nwogu CE, Groman A, Wilding G, Bain AJ, Hochwald SN, Khushalani NI. Outcomes of Endoscopic Resection for High-grade Dysplasia and Esophageal Cancer. Surg Endosc 2014 Apr; 28(4): 1090-5.
  • Dy G, Bogner P, Tan W, Demmy T, Farooq A, Chen H, Yendamuri S, Nwogu C, Bushunow PW, Gannon J, Adjei A, Adjei A, Ramnath N. Phase II Study of Perioperative Chemotherapy with Cisplatin and Pemetrexed in Non-small Cell Lung Cancer. J Thorac Oncol 2014; 9(2):222-30.
  • Hennon M, Yendamuri S. [Advance in Lung Cancer Surgery]. Zhongguo Fei Ai Za Zhi 2013; 16(3): C5-C8.
  • Yendamuri S, Sharma R, Demmy M, Groman A, Hennon M, Dexter E, Nwogu C, Miller A, Demmy T. Temporal Trends in Outcomes Following Sublobar and Lobar Resections for Small (≤2 cm) Non-small Cell Lung Cancers – a Surveillance Epidemiology End Results Database Analysis. J Surg Res 2013; 183 (1): 27-32.
  • Kukar M, Groman A, Malhotra U, Warren GW, Bogner P, Nwogu CE, Demmy TL, Yendamuri S. Small Cell Carcinoma of the Esophagus: A SEER Database Analysis. Ann Surg Oncol; 2013 Dec;20(13):4239-44. Epub 2013 Aug 14.
  • Dhillon SS, Yendamuri S. Needle Assembly Malfunction: An Unusal Complication Related to Endobronchial Ultrasound-guided Transbronchial Needle Aspiration. J Bronchology Interv Pulmonol. 2013; 20(3): 252-55.
  • Huang M, Manuballa S, Demmy TL, Yendamuri S. Transcervical Extended Mediastinal Lymphadenectomy – Indications and Technique. Indian Journal of Surgical Oncology. 2013; 4(2): 138-41.
  • Alosi J, Wilson JP, Yendamuri S, Dexter E. Planned Esophagectomy after Neoadjuvant Treatment versus Salvage/Delayed Esophagectomy. Ann Surg Oncol 2013; 20(Suppl. 1): S105.
  • Battoo A, Demmy TL, Yendamuri S. Complex Thoracoscopic Pulmonary Resections for the Treatment of Lung Cancer-A Review. Indian Journal of Surgical Oncology. 2013; 4(2): 142-47.
  • Platz TA, Nurkin SJ, Fong MK, Groman A, Flahert L, Malhotra U, Le Vea CM, Yendamuri S, Warren GW, Nava H, May KS. Neoadjuvant Chemoradiotherapy for Esophageal/gastroesophageal Carcinoma. J Gastrointest Oncol 2013; 4(2): 137-43.
  • Yendamuri S, Demmy T. Reply to the editor. J Thorac Cardiovasc Surg 2013; 145(4): 1150-1.
  • Nwogu C, Yendamuri S, Tan W, Kannisto E, Bogner PN, Morrison CD, Cheney RT, Dexter EU, Picone AL, Hennon MW, Hutson A, Reid ME, Adjei A, Demmy TL. Lung Cancer Lymph Node Micrometastasis Detection Using Real-time Polymerase Chain Reaction: Correlation with Vascular Endothelial Growth Factor Expression. J Thorac Cardiovasc Surg. 2013; 145(3):702-8.
  • Yendamuri S, Demmy TL. Author Reply. Ann Thorac Surg. 2013 Jan;95(1):385-86.
  • Yendamuri S, Sharma R, Demmy M, Groman A, Hennon M, Dexter E, Nwogu C, Miller A, Demmy T. Temporal Trends in Outcomes Following Sublobar and Lobar Resections for Small (≤2 cm) Non-small Cell Lung Cancers-a Surveillance Epidemiology End Results Database Analysis. Surg Res. 2012 Dec 19 (Epub)
  • Hennon M. Yendamuri S. Advances in Lung Cancer Surgery. J Carcinogenesis. 2012; 11:21.
  • Patnaik SK, Dahlgard J, Mazin W, Kannisto E, Jensen T, Knudsen S, Yendamuri S. Expression of MicroRNAs in the NCI-60 Cancer Cell-lines. PLoS One. 2012; 7(11): e49918.
  • Jayaprakash V, Loewen G, Mahoney M, Dhillon S, Yendamuri S, Hograth K, Delgado-Machare E, Reid M. Effect of Impaired Lung Function on the Development and Progression of Endobronchial Premalignant Lesions. J Cancer Therapy. 2012; 3(4A): 364-71.
  • Yendamuri S, Demmy TL. Typical Bronchial Carcinoid Tumor: Focus on Surgical Management. Ann Thor Surg 2013; 95(1): 385-6.
  • Jayaprakash V, Loewen G, Dhillon S, Moysich K, Mahoney M, Yendamuri Y, Hograth K, Reid M. Early Detection of Lung Cancer Using CT Scan and Bronchoscopy in a High Risk Population. J Cancer Therapy. 2012; 3(4A): 388-96.
  • Patnaik SK, Yendamuri S, Kannisto E, Kucharczuk JC, Singhal S, Vachani A. MicroRNA Expression Profiles of Whole Blood in Lung Adenocarcinoma. PLoS One. 2012;7(9):e46045. (Epub ahead of print Sep 28)
  • Demmy TL, Yendamuri S, Hennon MW, Dexter EU, Picone AL, Nwogu C. Thoracoscopic Maneuvers for Chest Wall Resection and Reconstruction. J Thorac Cardiovasc Surg. 2012 Sep; 144(3):S52-7. (Epub ahead of print Jun 27)
  • Yendamuri S, Caty L, Pine MB, Adem S, Bogner P, Miller A, Demmy TL, Groman A, Reid M. Outcomes of Sarcomatoid Carcinoma of the Lung – a SEER Database Analysis. Surgery 2012 Sep; 152(3):397-402. Jun 26. (Epub ahead of print Jun 26)
  • Yendamuri S, Demmy TL. Is VAMLA/TEMLA the New Standard of Pre-Resection Staging of Non-Small Cell Lung Cancer. J Thorac Cardiovasc Surg. 2012 Sep; 144(3): S14-S17. (Epub ahead of print Apr 13)
  • Nwogu CE, Groman A, Fahey D, Yendamuri S, Dexter E, Demmy T, Miller A, Reid M. Number of Lymph Nodes and Metastatic Lymph Node Ratio are Associated with Survival in Lung Cancer. Ann Thorac Surg. 2012 May; 93(5):1614-9; discussion 1619-20. Epub 2012 Mar 20.
  • Nurkin S, Nava H, Yendamuri S, LeVea C, Nwogu C, Wilding G, Khushalani N. Outcomes of Endoscopic Resection for High Grade Dysplasia and Esophageal Cancer. Gastrointest Endosc 2012; 75(4 Suppl.): 473.
  • Patnaik SK, Kannisto E, Yendamuri S. Factors affecting the yield of microRNAs from laser microdissectates of formalin-fixed tissue sections. BMC research notes 2012; 5 :40
  • Yendamuri S, Demmy TL. Is VAMLA/TEMLA the new standard of preresection staging of non-small cell lung cancer?. Journal of thoracic and cardiovascular surgery 2012; 1443:S14-S17
  • Nwogu CE, Groman A, Fahey D, Yendamuri S, Dexter E, Demmy TL, Miller A, Reid M. Number of lymph nodes and metastatic lymph node ratio are associated with survival in lung cancer. Annals of thoracic surgery 2012; 935:1614-1619; discussion 1619-1620
  • Yendamuri S, Caty L, Pine M, Adem S, Bogner P, Miller A, Demmy TL, Groman A, Reid M. Outcomes of sarcomatoid carcinoma of the lung: A Surveillance, Epidemiology, and End Results database analysis.Surgery 2012; 1523:397-402
  • Demmy TL, Yendamuri S, Hennon MW, Dexter EU, Picone AL, Nwogu C. Thoracoscopic maneuvers for chest wall resection and reconstruction. Journal of thoracic and cardiovascular surgery 2012;1443:S52-S57
  • Dahlgaard J, Mazin W, Jensen T, Pohl M, Bshara W, Hansen A, Kanisto E, Hamilton-Dutoit S, Hansen O, Hager H, Ditzel HJ, Yendamuri S, Knudsen S. Analytical variables influencing the performance of a miRNA based laboratory assay for prediction of relapse in stage I non-small cell lung cancer (NSCLC).BMC research notes 2011; 4:424
  • Yendamuri S , Gutierrez L , Oni A , Mashtare T , Khushalani N, Yang G , Nava H , Demmy T , Nwogu C.Does circular stapled esophagogastric anastomotic size affect the incidence of postoperative strictures?. Journal of surgical research 2011; 1651:1-4
  • Yendamuri S, Gold D, Jayaprakash V, Dexter E, Nwogu C, Demmy T. Is sublobar resection sufficient for carcinoid tumors? . Annals of thoracic surgery 2011; 925:1774-1778; discussion 1778-9
  • Yendamuri S, Demmy TL. Lobectomy for patients with limited lung function. Seminars in thoracic and cardiovascular surgery 2011; 233:191-195
  • Dhillon SS, Dhillon JK, Yendamuri S. Mediastinal staging of non-small-cell lung cancer. Expert review of respiratory medicine 2011; 56:835-850; quiz 851
  • Yendamuri S, Kratzke R. MicroRNA biomarkers in lung cancer: MiRacle or quagMiRe? . Translational research 2011; 1574:209-215
  • Patnaik SK, Kannisto E, Mallick R, Yendamuri S. Overexpression of the lung cancer-prognostic miR-146b microRNAs has a minimal and negative effect on the malignant phenotype of A549 lung cancer cells.PloS one 2011; 67:e22379
  • Kachare S, Dexter EU, Nwogu C, Demmy TL, Yendamuri S. Perioperative outcomes of thoracoscopic anatomic resections in patients with limited pulmonary reserve. Journal of thoracic and cardiovascular surgery 2011; 1412:459-462
  • Jayaprakash V, Cheng C, Reid M, Dexter EU, Nwogu CE, Hicks W, Sullivan M, Demmy TL, Yendamuri S.Previous head and neck cancers portend poor prognoses in lung cancer patients. Annals of thoracic surgery 2011; 923:1056-1061
  • Hennon M, Sahai RK, Yendamuri S, Tan W, Demmy TL, Nwogu C. Safety of thoracoscopic lobectomy in locally advanced lung cancer. Annals of surgical oncology 2011; 1813:3732-3736
  • Demmy TL, Platis IE, Nwogu C, Yendamuri S. Thoracoscopic extrapleural pneumonectomy for mesothelioma. Annals of thoracic surgery 2011; 912:616-618
  • Bhaskarla A, Tang PC, Mashtare T, Nwogu CE, Demmy TL, Adjei AA, Reid ME, Yendamuri S. Analysis of second primary lung cancers in the SEER database. Journal of surgical research 2010; 1621:1-6
  • Lee RY , Flaherty L , Khushalani NI , Kanehira K , Nwogu C , Yendamuri S , Nava HR , Yang GY. Aorto-esophageal fistula: a rare fatal case caused by esophageal malignancy. Journal of gastrointestinal oncology 2010; 11:64-67
  • May KS , Lamonica D , Nava HR , Gibbs JF , Yendamuri SS , Nwogu CE , Iyer RV , Yap JC , Warner JC , Russo RC , Malhotra HK , Flaherty L , Wilding GE , Chandrasekhar R , Khushalani NI , Yang GY , Thomas Jr CR.Association of Technetium(99m) MAG-3 renal scintigraphy with change in creatinine clearance following chemoradiation to the abdomen in patients with gastrointestinal malignancies. Journal of gastrointestinal oncology 2010; 11:7-15
  • Patnaik SK, Mallick R, Yendamuri S. Detection of microRNAs in dried serum blots. Analytical biochemistry 2010; 4071:147-149
  • Nwogu CE, Yendamuri S, Demmy TL. Does thoracoscopic pneumonectomy for lung cancer affect survival?. Annals of thoracic surgery 2010; 896:S2102-S2106
  • Patnaik SK, Kannisto E, Knudsen S, Yendamuri S. Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection. Cancer research 2010; 701:36-45
  • Patnaik SK , Mallick R , Yendamuri S. MicroRNAs and esophageal cancer. Journal of gastrointestinal oncology 2010; 11:55-63
  • Mallick R, Patnaik S, Yendamuri S. MicroRNAs and lung cancer: Biology and applications in diagnosis and prognosis. Journal of carcinogenesis 2010; 9:8
  • Yendamuri S. MicroRNAs and prognosis of lung cancer. Seminars in thoracic and cardiovascular surgery 2010; 224:269-270
  • Patnaik SK, Kannisto E, Yendamuri S. Overexpression of microRNA miR-30a or miR-191 in A549 lung cancer or BEAS-2B normal lung cell lines does not alter phenotype. PloS one 2010; 52:e9219
  • Yang GY, Fakih M, Gibbs JF, Yendamuri SS, Khushalani NI, McCloskey SA, Wilding GE, Chandrasekhar R, Iyer RV, May KS, Thomas Jr CR. Renal atrophy secondary to chemoradiotherapy of abdominal malignancies. International journal of radiation oncology, biology, physics 2010; 782:539-546
  • Demmy TL, Nwogu CE, Yendamuri S. Thoracoscopic chest wall resection: what is its role?. Annals of thoracic surgery 2010; 896:S2142-S2145
  • Demmy TL, Nwogu C, Solan P, Yendamuri S, Wilding G, DeLeon O. Chest tube-delivered bupivacaine improves pain and decreases opioid use after thoracoscopy. Annals of thoracic surgery 2009;874:1040-1046; discussion 1046-1047
  • Sahai RK, Nwogu CE, Yendamuri S, Tan W, Wilding GE, Demmy TL. Is thoracoscopic pneumonectomy safe?. Annals of thoracic surgery 2009; 884:1086-1092
  • Bogner PN, Patnaik SK, Pitoniak R, Kannisto E, Repasky E, Hylander B, Yendamuri S, Ramnath N. Lung cancer xenografting alters microRNA profile but not immunophenotype. Biochemical and biophysical research communications 2009; 3862:305-310
  • Yendamuri S, Calin GA. The role of microRNA in human leukemia: a review. Leukemia 2009; 237:1257-1263
  • Yendamuri S, Nwogu CE, Demmy TL. Thoracoscopic lobectomy with chest wall resection after neoadjuvant therapy. Innovations (Philadelphia, Pa.) 2009; 41:36-38
  • Demmy TL, Tomaszewski G, Dy GK, Yendamuri S, Nwogu C, Pendyala L, Ramnath N, Adjei AA.Thoracoscopic organ suffusion for regional lung chemotherapy (preliminary results). Annals of thoracic surgery 2009; 882:385-390; discussion 390-391
  • Yendamuri S, Roth JA, Walsh GL, Swisher SG, Spitz MR, Rice DC, Mehran RJ, Jiang F, Hofstetter WL, Bekele NB, Fernandez R, Feng L, Zaidi T, Vaporciyan AA, Katz RL. 3p22.1 and 10q22.3 deletions detected by fluorescence in situ hybridization (FISH): a potential new tool for early detection of non-small cell lung Cancer (NSCLC). Journal of thoracic oncology 2008; 39:979-984
  • Yendamuri S, Trapasso F, Calin GA. ARLTS1 - a novel tumor suppressor gene. Cancer letters 2008;2641:11-20