Understanding the molecular causes of cancer

Cancer is characterized by a multitude of genetic and gene expression alterations. We are trying to understand which changes drive cancer progression and use this information to develop more effective drugs.

Through a combination of computational and experimental methods, we study how genes are regulated in cancer, and how changes in gene regulation and cell signaling networks drive tumor progression.

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The landscape of alternative polyadenylation in pancreatic cancer

Research Focus: Gene Regulatory Alterations

Our current focus is a mutation-independent gene regulatory process, alternative polyadenylation (APA).

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Expression of the orphan GPCR GPR161 in tissue

Research Focus: G-protein Coupled Receptors (GPCRs)

We seek to probe the role of GPCR-mediating signaling in cancer pathogenesis and use this information to develop novel therapies.

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Neurofibromatosis

In the News

Roswell Park Team Discovers New Mechanism Driving Pancreatic Cancer

Contact Information

Contact the Feigin Lab

Email: Michael.Feigin@RoswellPark.org
Phone: 716-845-5824
Office: Center for Genetics & Pharmacology (CGP) L4-317
Lab: Center for Genetics & Pharmacology (CGP) L4-135

Department of Pharmacology and Therapeutics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263