Understanding the molecular causes of cancer
Cancer is characterized by a multitude of genetic and gene expression alterations. We are trying to understand which changes drive cancer progression and use this information to develop more effective drugs.
Through a combination of computational and experimental methods, we study how genes are regulated in cancer, and how changes in gene regulation and cell signaling networks drive tumor progression.
Research focus: Gene regulatory alterations
Our current focus is a mutation-independent gene regulatory process, alternative polyadenylation (APA).
Research focus: G-protein Coupled Receptors (GPCRs)
We seek to probe the role of GPCR-mediating signaling in cancer pathogenesis and use this information to develop novel therapies.
In the news
Roswell Park team discovers new mechanism driving pancreatic cancer
Contact the Feigin Lab
Office: Center for Genetics & Pharmacology (CGP) L4-317
Lab: Center for Genetics & Pharmacology (CGP) L4-135
Department of Pharmacology and Therapeutics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263