Understanding the molecular causes of cancer
Cancer is characterized by a multitude of genetic and gene expression alterations. We are trying to understand which changes drive cancer progression and use this information to develop more effective drugs.
Through a combination of computational and experimental methods, we study how genes are regulated in cancer, and how changes in gene regulation and cell signaling networks drive tumor progression.
Research focus: Gene regulatory alterations
Our current focus is a mutation-independent gene regulatory process, alternative polyadenylation (APA).
Research focus: G-protein Coupled Receptors (GPCRs)
We seek to probe the role of GPCR-mediating signaling in cancer pathogenesis and use this information to develop novel therapies.
In the news
Roswell Park team discovers new mechanism driving pancreatic cancer
Contact the Feigin Lab
Department of Pharmacology and Therapeutics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263