A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60
- Journal: Journal of Clinical Investigation, July 2022
- Authors: Kumar R, Chaudhary AK, Woytash J, Inigo JR, Gokhale AA, Bshara W, Attwood K, Wang J, Spernyak JA, Rath E, Yadav N, Haller D, Goodrich DW, Tang DG, Chandra D.
- Citation: J Clin Invest. 2022 Jul 1;132(13):e149906. doi: 10.1172/JCI149906.
Senior author publications
- Inigo JR, et al. Targeting the mitochondrial unfolded protein response in cancer: opportunities and challenges. Trends Cancer. 2021 Dec;7(12):1050-1053. doi: 10.1016/j.trecan.2021.08.008. Epub 2021 Sep 24. PMID: 34580036; PMCID: PMC9287746.
- O'Malley J, et al. Mitochondrial Stress Response and Cancer. Trends Cancer. 2020 Aug;6(8):688-701. doi: 10.1016/j.trecan.2020.04.009. Epub 2020 May 22. PMID: 32451306; PMCID: PMC7392807.
- Yadav N, et al. Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer. Biochim Biophys Acta Mol Cell Res. 2020 Jan;1867(1):118573. doi: 10.1016/j.bbamcr.2019.118573. Epub 2019 Oct 31. PMID: 31678591; PMCID: PMC7733678.
- Kumar R, et al. Cytochrome c-Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer. Cancer Res. 2019 Apr 1;79(7):1353-1368. doi: 10.1158/0008-5472.CAN-18-2383. Epub 2019 Feb 14. PMID: 30765600; PMCID: PMC6445777.
- Kumar S, et al. Hsp60 and IL-8 axis promotes apoptosis resistance in cancer. Br J Cancer. 2019 Nov;121(11):934-943. doi: 10.1038/s41416-019-0617-0. Epub 2019 Nov 1. PMID: 31673102; PMCID: PMC6889399.
- Yadav N, et al. Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents. Cell Death Dis. 2015 Nov 5;6(11):e1969. doi: 10.1038/cddis.2015.305. PMID: 26539916; PMCID: PMC4670921.
- Yadav N, et al. Transformations of the macromolecular landscape at mitochondria during DNA-damage-induced apoptotic cell death. Cell Death Dis. 2014 Oct 9;5(10):e1453. doi: 10.1038/cddis.2014.405. PMID: 25299778; PMCID: PMC4649512.
- Koochekpour S, et al. Reduced mitochondrial DNA content associates with poor prognosis of prostate cancer in African American men. PLoS One. 2013 Sep 23;8(9):e74688. doi: 10.1371/journal.pone.0074688. PMID: 24086362; PMCID: PMC3781126.
- Gogada R, et al. Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. J Biol Chem. 2013 Jan 4;288(1):368-81. doi: 10.1074/jbc.M112.386102. Epub 2012 Nov 14. PMID: 23152504; PMCID: PMC3537034.
- Chaudhary AK, O'Malley J, Kumar S, Inigo JR, Kumar R, Yadav N, Chandra D. Mitochondrial dysfunction and prostate cancer racial disparities among American men. Front Biosci (Schol Ed). 2017 Jan 1;9(1):154-164. doi: 10.2741/s479. PMID: 27814581.
- Gogada R, Prabhu V, Amadori M, Scott R, Hashmi S, Chandra D. Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. J Biol Chem. 2011 Aug 19;286(33):28749-60. PMID: 21712378.
- Chandra D*, Bratton SB, Person MD, Tian Y, Martin AG, Ayres M, Fearnhead HO, Gandhi V, Tang DG*. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell. 2006 Jun 30;125(7):1333-46. PMID: 16814719. *Corresponding authors.
Connect with the Chandra Lab
Email: Dhyan.Chandra@RoswellPark.org
Phone: 716-845-4882
Department of Pharmacology & Therapeutics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263