Exciting discoveries from the Chakraborty Lab can be found in reputed journals, including Nature Communications, Nature Materials, Cell Reports Medicine, Cell Reports, PNAS, and PloS Pathogens.

Figure from a scientific research study

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR-Addicted Lung Tumorgenesis

  • Publication: Advanced Science, April 2025
  • Authors: Mokhtari RB, Sampath D, Eversole P, Yu Lin MO, Bosykh DA, Boopathy GTK, Sivakumar A, Wang CC, Kumar R, Sheng JYP, Karasik E, Foster BA, Yu H, Ling X, Wu W, Li F, Ohler ZW, Brainson CF, Goodrich DW, Hong W, Chakraborty S.
  • Citation: Adv Sci (Weinh). 2025 Mar 31:e2413443. doi: 10.1002/advs.202413443. Epub ahead of print. PMID: 40165020.

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Circulatory Agrin Serves as a Prognostic Indicator for Hepatocellular Carcinoma

  • Publication: Cancers (Basel), July 2024 . 2024 Jul
  • Authors: Kapoor A, Bayat Mokhtari R, Sonti SS, Patel R, George A, Attwood K, Iyer R, Chakraborty S.
  • Citation: Cancers (Basel). 2024 Jul 31;16(15):2719. doi: 10.3390/cancers16152719

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YAP/TAZ Drive Agrin-Matrix Metalloproteinase-12 Mediated Diabetic Skin Wound Healing

  • Publication: Journal of Investigative Dermatology, May 2024
  • Authors: Yu Lin MO, Sampath D, Bosykh DA, Wang C, Wang X, Subramaniam T, Han W, Hong W, Chakraborty S.
  • Citation: J Invest Dermatol. 2024 May 27:S0022-202X(24)00391-9. doi: 10.1016/j.jid.2024.05.005. Epub ahead of print. PMID: 38810954.

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The extracellular matrix in hepatocellular carcinoma: Mechanisms and therapeutic vulnerability

  • Publication: Cell Reports Medicine, August 2023
  • Authors: Roy AM, Iyer R, Chakraborty S
  • Citation: Cell Rep Med. 2023 Aug 25:101170.

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The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment

  • Publication: Cancers (Basel), July 2023
  • Authors: Mokhtari RB, Ashayeri N, Baghaie L, Sambi M, Satari K, Baluch N, Bosykh DA, Szewczuk MR, Chakraborty S
  • Citation: Cancers (Basel). 2023 Jul 2;15(13):3468.

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Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing

  • Publication: Nature Communications, November 2021
  • Authors: Chakraborty S, Sampath D, Ong Yu-Lin M, Bilton M, Huang CK, Njah K, Goy P, Wang C, Guccione E, Lim CT and Wanjin Hong
  • Citation: Nat Commun. 2021 Nov 3;12(1):6349.

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Agrin Mediates Angiogenesis in the Tumor Microenvironment

  • Publication: Trends in Cancer, February 2020
  • Authors: Chakraborty S, Njah K, Hong W
  • Citation: Trends Cancer. 2020 Feb;6(2):81-85.

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A role of Agrin in maintaining the stability of vascular endothelial receptor-2 during tumor angiogenesis

  • Publication: Cell Reports, July 2019
  • Authors: Chakraborty S, Njah K, Qiu B, Arumugam S, Lakshmanan M, Tergaonkar V, Thibault G, Wang X, Hong W
  • Citation: Cell Rep. 2019 Jul 23;28(4):949-965.e7.

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Agrin as a mechanotransduction signal regulating YAP through the Hippo pathway

  • Publication: Cell Reports, March 2017
  • Authors: Chakraborty S, Kizito N, Pobbati AV, Lim YB, Raju A, Lakshmanan M, Tergaonkar V, Lim CT, Hong W
  • Citation: Cell Rep. 2017 Mar 7;18(10):2464-2479.

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An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

  • Publication: Nature Communications, January 2015
  • Authors: Chakraborty S, Lakshmanan M, Swa HL, Chen J, Zhang X, Ong YS, Loo LS, Gunaratne J, Tergaonkar V, Hui KM, Hong W
  • Citation: Nat Commun. 2015 Jan 29;6:6184.

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Department of Pharmacology & Therapeutics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263