While in Medical School I focused my research on the investigation of morphological and functional imaging of hematological diseases, especially monoclonal plasma cell disorders. Our group has established magnetic resonance imaging (MRI) and computed tomography (CT) as novel standard diagnostic techniques in multiple myeloma and its precursor diseases. The discovery of a heterogeneity in growth patterns in myeloma has led us to focus on the significance of a spatial heterogeneity for genomic assessment and treatment monitoring especially minimal residual disease assessment.
The huge amount of information coming from whole body imaging motivated us to start the development of software tools to support the radiologist and nuclear medicine specialist in evaluating the clinical data and to make this "big imaging data" available for research. Dealing with myeloma patients in advanced stages of the disease and analyzing imaging results of modern imaging techniques has led to a deeper interest in myeloma bone disease, where we have started to investigate the influence of physical activity on pain, quality of life and skeletal related events. Having been responsible for the largest autologous stem cell transplant program in Germany has also motivated me to investigate how treatment with high dose chemotherapy can be improved regarding outcome and tolerability.
- Mosebach J, Shah S, Delorme S, Hielscher T, Goldschmidt H, Schlemmer HP, Schönland SO, Hegenbart U, Hillengass J. Prognostic significance of tumor burden assessed by whole-body magnetic resonance imaging in multiple myeloma patients treated with allogeneic stem cell transplantation. Haematologica. 2017 Dec 7. pii: haematol.2017.176073. doi: 10.3324/haematol.2017.176073.
- Hillengass J, Moulopoulos LA, Delorme S, Koutoulidis V, Mosebach J, Hielscher T, Drake M, Rajkumar SV, Oestergaard B, Abildgaard N, Hinge M, Plesner T, Suehara Y, Matsue K, Withofs N, Caers J, Waage A, Goldschmidt H, Dimopoulos MA, Lentzsch S, Durie B, Terpos E.
- Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group. Blood Cancer J. 2017 Aug 25;7(8):e599. doi: 10.1038/bcj.2017.78.
- Hillengass J, Weber MA, Kilk K, Listl K, Wagner-Gund B, Hillengass M, Hielscher T, Farid A, Neben K, Delorme S, Landgren O, Goldschmidt H. Prognostic significance of whole-body MRI in patients with monoclonal gammopathy of undetermined significance. Leukemia. 2014 Jan;28(1):174-8. doi: 10.1038/leu.2013.244. Epub 2013 Aug 20.
- Hillengass J, Fechtner K, Weber MA, Bäuerle T, Ayyaz S, Heiss C, Hielscher T, Moehler TM, Egerer G, Neben K, Ho AD, Kauczor HU, Delorme S, Goldschmidt H. Prognostic significance of focal lesions in whole-body magnetic resonance imaging in patients with asymptomatic multiple myeloma. J Clin Oncol. 2010 Mar 20;28(9):1606-10. doi: 10.1200/JCO.2009.25.5356. Epub 2010 Feb 22.
- Merz M, Hielscher T, Wagner B, Sauer S, Shah S, Raab MS, Jauch A, Neben K, Hose D, Egerer G, Weber MA, Delorme S, Goldschmidt H, Hillengass J. Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma. Leukemia. 2014 Sep;28(9):1902-8. doi: 10.1038/leu.2014.75. Epub 2014 Feb 18.