Grading and Staging of Neuroendocrine Cancer

Staging for neuroendocrine tumors is not the red flag it is for other cancers. Unlike other cancers, patients can live a long time even with an advanced or Stage IV neuroendocrine tumor. The treatment for a Stage IV neuroendocrine tumor may be very different than the treatment of another cancer at the same stage. For example, doctors may surgically remove a Stage IV neuroendocrine tumor, while surgery might not help a patient with a different cancer in such a late stage.

Neuroendocrine tumors can be classified as low grade or high grade.

A low grade, or well-differentiated tumor, can be treated with surgery and ablation therapy. The aim is to eliminate as many of the tumors as possible. These techniques can be followed by chemotherapy, and these tumors respond well to chemotherapy.

High grade neuroendocrine carcinomas are more aggressive. They are treated with chemotherapy. However, high grade tumors aren’t as responsive to chemotherapy as low grade tumors.