Michael Nemeth

PhD

Specializing In:

Hematopoiesis Leukemia

Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • Assistant Professor of Oncology
  • Translational Research, Departments of Medicine & Immunology
  • Director of Graduate Studies, Department of Immunology

Background

Education and Training:

  • 1996-2001 - PhD - Pharmacology and Toxicology - Dartmouth Medical School, Hanover, NH

Fellowship:

  • 2001-2008 - Post-Doctoral Fellow, Hematology, National Human Genome Research Institute, Bethesda, MD

Professional Memberships:

  • American Society of Hematology

Professional Experience:

  • 2008 - Present - Departments of Medicine and Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY

Research

Research Overview:

Our overall research program focuses on the mechanisms that regulate normal and malignant hematopoiesis. We focus on mechanisms by which dysregulation of the immune system in myeloid cancers regulates disease progression and how this can be reversed to improve clinical responses in MDS.

Lab Members:

Jennifer Peresie


Publications

Full Publications list on PubMed

Griffiths EA, Srivastava P, Matsuzaki J, Brumberger Z, Wang ES, Kocent J, Miller A, Roloff GW, Wong HY, Paluch BE, Lutgen-Dunckley LG, Martens BL, Odunsi K, Karpf AR, Hourigan CS, Nemeth MJ. NY- ESO-1 Vaccination in Combination with Decitabine Induces Antigen-Specific T-Lymphocyte Responses in Patients with Myelodysplastic Syndrome. Clin Cancer Res. 2018 Mar 1;24(5):1019-1029. doi: 10.1158/1078-0432.CCR-17-1792. Epub 2017 Sep 25. PMID: 28947565. PMCID: PMC5844797

Srivastava P, Paluch BE, Matsuzaki J, James SR, Collamat-Lai G, Blagitko-Dorfs N, Ford LA, Naqash R, Lübbert M, Karpf AR, Nemeth MJ (Co-Senior Author), Griffiths EA. Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy. Oncotarget. 2016 Mar 15;7(11):12840-56. doi: 10.18632/oncotarget.7326 Epub 2016 Feb 11. PMID: 26883197. PMCID: PMC4914325

Srivastava P, Paluch BE, Matsuzaki J, James SR, Collamat-Lai G, Karbach J, Nemeth MJ, Taverna P, Karpf AR, Griffiths EA. Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts. Leuk Res. 2014 Nov;38(11):1332-41. Epub 2014 Sep 10. PMID: 25260825. 

Waight JD, Banik D, Griffiths EA, Nemeth MJ (Co-Senior Author), Abrams SI. Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia. J Biol Chem. 2014 May 30;289(22):15642-52. doi: 10.1074/jbc.M113.544320. Epub 2014 Apr 21. PubMed PMID: 24753251; PubMed Central PMCID: PMC4140919. 

Netherby CS, Messmer MN, Burkard-Mandel L, Colligan S, Miller A, Cortes Gomez E, Wang J, Nemeth MJ, Abrams SI. The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production. J Immunol. 2017 Mar 29. pii: 1601722. doi: 10.4049/jimmunol.1601722. [Epub ahead of print] PubMed PMID: 28356386.