Postdoctoral Position in Urology (Bladder Cancer Program)

Health Research Inc. (HRI) Roswell Park Division
Full Time
Commensurate with accumulated relevant research experience and NIH pay scale
Description of Duties

We are seeking an enthusiastic and talented candidate with a Ph.D. in cancer biology, genetics, molecular biology, experimental therapeutics, bioinformatics or related field.

  • Perform a variety of routine and specialized lab tests and experimental procedures. 
  • Have access to patient database, tissue specimen, cell culture, patient-derived xenograft, next-generation sequencing and genetic mouse model.
  • Assist with writing animal and human trial protocols, manuscripts, and grants.

Research Projects

Identify novel therapeutic targets that drive bladder cancer development and progression.

  1. Xu, D et al. A Preclinical Study to Repurpose Spironolactone for Enhancing Chemotherapy Response in Bladder Cancer. Molecular Cancer Therapeutics. 2022 May 4;21(5):786-798. doi: 10.1158/1535-7163.

Genetically engineered mouse models (GEMMs) of bladder cancer to investigate molecular mechanisms of bladder cancer variant histology, differentiation, progression, and metastasis using in vivo analyses of GEMMs and patient-derived organoid models.

  1. Xu, D et al. Single-Cell Analyses of a Novel Mouse Urothelial Carcinoma Model Reveal a Role of Tumor-Associated Macrophages in Response to Anti-PD-1 Therapy. Cancers (In Press).
  2. Xu, D et al. Ex Vivo Organoid Model of Adenovirus-Cre 582 Mediated Gene Deletions in Mouse Urothelial Cells. J. Vis. Exp. 2022, e63855, doi:10.3791/63855.)
  • Research experience in human genetics, drug experiments & molecular biology.
  • Experience with genetically engineered mouse models, mouse breeding/care.
  • Demonstrated proficiency in data analysis in molecular and cancer biology.
  • Publications in high-impact peer-reviewed journals.
  • Excellent written and verbal communication and organizational skills.
  • Optional experience with next-generation sequencing data, RNAseq, single-cell sequencing and common analysis tool.
Applicant Instructions

The candidate is expected to be highly motivated, possess excellent presentation and interpersonal skills. Interested candidates should submit a cover letter, curriculum vitae and contact information of three referees to: