Postdoctoral Position in Urology (Bladder Cancer Program)

Company
Health Research Inc. (HRI) Roswell Park Division
Department
Urology
Hours/Shift
Full Time
Salary
Commensurate with accumulated relevant research experience and NIH pay scale
Description of Duties

We are seeking an enthusiastic and talented candidate with a Ph.D. in cancer biology, genetics, molecular biology, experimental therapeutics, bioinformatics or related field.

  • Perform a variety of routine and specialized lab tests and experimental procedures. 
  • Have access to patient database, tissue specimen, cell culture, patient-derived xenograft, next-generation sequencing and genetic mouse model.
  • Assist with writing animal and human trial protocols, manuscripts, and grants.

Research Projects

Identify novel therapeutic targets that drive bladder cancer development and progression.

  1. Xu, D et al. A Preclinical Study to Repurpose Spironolactone for Enhancing Chemotherapy Response in Bladder Cancer. Molecular Cancer Therapeutics. 2022 May 4;21(5):786-798. doi: 10.1158/1535-7163.

Genetically engineered mouse models (GEMMs) of bladder cancer to investigate molecular mechanisms of bladder cancer variant histology, differentiation, progression, and metastasis using in vivo analyses of GEMMs and patient-derived organoid models.

  1. Xu, D et al. Single-Cell Analyses of a Novel Mouse Urothelial Carcinoma Model Reveal a Role of Tumor-Associated Macrophages in Response to Anti-PD-1 Therapy. Cancers (In Press).
  2. Xu, D et al. Ex Vivo Organoid Model of Adenovirus-Cre 582 Mediated Gene Deletions in Mouse Urothelial Cells. J. Vis. Exp. 2022, e63855, doi:10.3791/63855.)
Qualifications
  • Research experience in human genetics, drug experiments & molecular biology.
  • Experience with genetically engineered mouse models, mouse breeding/care.
  • Demonstrated proficiency in data analysis in molecular and cancer biology.
  • Publications in high-impact peer-reviewed journals.
  • Excellent written and verbal communication and organizational skills.
  • Optional experience with next-generation sequencing data, RNAseq, single-cell sequencing and common analysis tool.
Applicant Instructions

The candidate is expected to be highly motivated, possess excellent presentation and interpersonal skills. Interested candidates should submit a cover letter, curriculum vitae and contact information of three referees to: Qiang.Li@RoswellPark.org.