Researchers from Roswell Park Comprehensive Cancer Center report that a new approach to immunotherapy could overcome some of the challenges of treating ovarian cancer by leveraging the power of endogenous (host) T cells using engineered T cells to deliver bispecific T-cell engagers, commonly referred to as BiTEs — a trademarked term for a type of fusion protein. The research team believes this strategy could improve treatment outcomes in ovarian cancer, for which immunotherapy has been largely ineffective. Findings from their preclinical study lay the groundwork for a new approach to targeting folate receptor alpha (FR⍺), an antigen commonly present in epithelial ovarian cancer and associated with advanced disease, chemotherapy resistance and disease relapse.