Ajay Gupta

Pediatric Oncology
Buffalo Spree Top Doctor 2024

Dr. Gupta is a Buffalo Spree Top Doctor! See all of our physicians who made this year's list.

Top Doctors 2024

Cancers Treated:

Specializing In:

Developmental therapeutics Early phase clinical trials Adolescents and Young Adults (AYA)

About Ajay Gupta


My name is Dr. Ajay Gupta, and I’m a pediatric oncologist with Roswell Park Oishei Children’s Cancer and Blood Disorders Program. I specialize in sarcomas in children, adolescents, and young adults (AYA), with a specific interest in Ewing sarcoma, osteosarcoma, and soft tissue sarcomas. I see both pediatric and adult patients and I also see adults with neurofibromatosis (NF) in our NF Multidisciplinary Clinic. I am both an active clinician and dedicated researcher.

As a part of my research program here at Roswell Park, I manage the sarcoma clinical trials portfolio and am very pleased to have opened in Buffalo available national trials for GIST (gastrointestinal stromal tumor), UPS or undifferentiated pleomorphic sarcoma, liposarcoma (including DDLPS), leiomyosarcoma, angiosarcoma, myxofibrosarcoma, osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma. Our team is available to evaluate any patients for these opportunities.

I am on the SARC Multidisciplinary Tumor Board. I am on the NCCN Pediatric Soft Tissue Sarcoma panel and the Pediatric Bone Sarcoma Panel. I am a part of the Children’s Oncology Group (COG) Localized Ewing Sarcoma Task Force, and the International Society of Paediatric Oncology (SIOP) Young SIOP Network. I regularly attend the National Ewing Sarcoma Tumor Board, the MIB Tumor Review Board for Osteosarcoma (TURBO), the Desmoid Tumor Research Foundation (DTRF) Virtual Tumor Board, the Synovial Sarcoma Tumor Board, and the Rare Tumors Tele Tumor Board.

I earned my medical degree from Albany Medical College in Albany, NY. I completed my residency in pediatrics at Miami Children's Hospital in Miami, FL, and completed fellowships in pediatric hematology/oncology and pediatric sarcoma at Rainbow Babies & Children's Hospital in Cleveland, OH and Nationwide Children's Hospital in Columbus, OH, respectively. I also earned a Masters in Translational Pharmacology from the Ohio State University.

I am board certified in both general pediatrics and pediatric hematology/oncology by the American Board of Pediatrics. I’m also a member of the American Society of Hematology, the Children’s Oncology Group, the American Society of Pediatric Hematology/Oncology, the American Association of Cancer Research, the American Society of Clinical Oncology, the International Society of Paediatric Oncology, and the American Society for Clinical Pharmacology & Therapeutics.

In addition to providing ongoing care to my pediatric sarcoma and solid tumor patients, I am also available for second opinions.


Roswell Park Comprehensive Cancer Center
  • Assistant Professor of Oncology
  • Department of Pediatric Oncology

Jacobs School Of Medicine And Biomedical Sciences, State University of New York at Buffalo

  • Assistant Professor of Pediatrics


Education and Training:

  • 2019-2020 - MS - Translational Pharmacology, The Ohio State University, Columbus, OH
  • 2009-2013 - MD - Albany Medical College, Albany, NY


  • 2013-2016 - Pediatrics, Miami Children's Hospital, Miami, FL


  • 2019-2020 - Pediatric Sarcoma, Nationwide Children's Hospital, Columbus, OH
  • 2016-2019 - Pediatric Hematology/Oncology, Rainbow Babies & Children's Hospital, Cleveland, OH

Board Certification:

  • 2016 - American Board of Pediatrics

Professional Memberships:

  • 2019-present - American Society for Clinical Pharmacology & Therapeutics
  • 2019-present - International Society of Paediatric Oncology
  • 2019-present - American Society of Clinical Oncology
  • 2018-present - American Association of Cancer Research
  • 2017-present - American Society of Hematology
  • 2015-present - American Society of Pediatric Hematology/Oncology

Clinical Trials

Featured on Cancer Talk


Full Publications list on PubMed

Gupta A, Riedel RF, Shah C, Borinstein SC, Isakoff MS, Chugh R, Rosenblum JM, Murphy ES, Campbell SR, Albert CM, Zahler S, Thomas SM, Trucco M. Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board. Cancer. 2023 Nov 1;129(21):3363-3371. https://pubmed.ncbi.nlm.nih.gov/37403815/

Gupta A, Cripe TP. Immunotherapies for Pediatric Solid Tumors: A Targeted Update. Paediatr Drugs. 2022 Jan;24(1):1-12. https://pubmed.ncbi.nlm.nih.gov/34822115/

Gupta A, Liu H, Schieffer KM, Koo SC, Cottrell CE, Mardis ER, Roberts RD, Yeager ND. Targeted Therapy in a Young Adult With a Novel Epithelioid Tumor Driven by a PRRC2B-ALK Fusion. J Natl Compr Canc Netw. 2021 Oct 15;19(10):1116-1121. https://pubmed.ncbi.nlm.nih.gov/34666310/

Gupta A, Belsky JA, Schieffer KM, Leraas K, Varga E, McGrath SD, Koo SC, Magrini V, Wilson RK, White P, Mardis ER, Jatana KR, Cottrell CE, Setty BA.  Infantile fibrosarcoma-like tumor driven by novel RBPMS-MET fusion consolidated with cabozantinib. Cold Spring Harb Mol Case Stud. 2020 Oct;6(5). https://pubmed.ncbi.nlm.nih.gov/33028644/

Gupta A, Taslim C, Tullius BP, Cripe TP. Therapeutic modulation of the CD47-SIRPα axis in the pediatric tumor microenvironment: working up an appetite. Cancer Drug Resist. 2020;3(3):550-562. https://doi.org/10.20517/cdr.2020.12