Ajay Gupta

Pediatric Oncology
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Top Doctors 2023

Cancers Treated:

Specializing In:

Solid tumors, Developmental therapeutics, Early phase clinical trials, Adolescents and Young Adults (AYA)

About Ajay Gupta


My name is Dr. Ajay Gupta, and I’m a pediatric oncologist with Roswell Park Oishei Children’s Cancer and Blood Disorders Program. I specialize in sarcomas in children, adolescents, and young adults (AYA), with a specific interest in Ewing sarcoma. I am both an active clinician and dedicated researcher.

I recently received a grant through Hyundai Hope on Wheels in collaboration with Dr. Joyce Ohm, also at Roswell Park, to study a potential weakness in Ewing sarcoma cancer cells known as replication stress. We hope to combine a drug targeting this weakness with standard drugs known to work in Ewing sarcoma in a future early phase clinical trial here at Roswell.

I am a part of the Children’s Oncology Group (COG) Localized Ewing Sarcoma Task Force, the American Academy of Pediatrics (AAP) Solid Tumors Policy Review Work Group, and the International Society of Paediatric Oncology (SIOP) Young SIOP Network. I regularly attend the National Ewing Sarcoma Tumor Board and the Rare Tumors Tele Tumor Board.

I earned my medical degree from Albany Medical College in Albany, NY. I completed my residency in pediatrics at Miami Children's Hospital in Miami, FL, and completed fellowships in pediatric hematology/oncology and pediatric sarcoma at Rainbow Babies & Children's Hospital in Cleveland, OH and Nationwide Children's Hospital in Columbus, OH, respectively. I also earned a Masters in Translational Pharmacology from the Ohio State University.

I am board certified in both general pediatrics and pediatric hematology/oncology by the American Board of Pediatrics. I’m also a member of the American Society of Hematology, the Children’s Oncology Group, the American Society of Pediatric Hematology/Oncology, the American Association of Cancer Research, the American Society of Clinical Oncology, the International Society of Paediatric Oncology, and the American Society for Clinical Pharmacology & Therapeutics.

In addition to providing ongoing care to my pediatric sarcoma and solid tumor patients, I am also available for second opinions.


Roswell Park Comprehensive Cancer Center

  • Assistant Professor of Oncology
  • Department of Pediatric Oncology

Jacobs School Of Medicine And Biomedical Sciences, State University of New York at Buffalo

  • Assistant Professor of Pediatrics


Education and Training:

  • 2019-2020 - MS - Translational Pharmacology, The Ohio State University, Columbus, OH
  • 2009-2013 - MD - Albany Medical College, Albany, NY


  • 2013-2016 - Pediatrics, Miami Children's Hospital, Miami, FL


  • 2019-2020 - Pediatric Sarcoma, Nationwide Children's Hospital, Columbus, OH
  • 2016-2019 - Pediatric Hematology/Oncology, Rainbow Babies & Children's Hospital, Cleveland, OH

Board Certification:

  • 2016 - American Board of Pediatrics

Professional Memberships:

  • 2019-present - American Society for Clinical Pharmacology & Therapeutics
  • 2019-present - International Society of Paediatric Oncology
  • 2019-present - American Society of Clinical Oncology
  • 2018-present - American Association of Cancer Research
  • 2017-present - American Society of Hematology
  • 2015-present - American Society of Pediatric Hematology/Oncology

Clinical Trials

Featured on Cancer Talk


Full Publications list on PubMed

Gupta A, Belsky JA, Schieffer KM, Leraas K, Varga E, McGrath SD, Koo SC, Magrini V, Wilson RK, White P, Mardis ER, Jatana KR, Cottrell CE, Setty BA. Infantile fibrosarcoma-like tumor driven by novel RBPMS-MET fusion consolidated with cabozantinib. Cold Spring Harb Mol Case Stud. 2020 Oct 7;6(5):a005645.

Gupta A, Damania RC, Talati R, O'Riordan MA, Matloub YH, Ahuja SP. Increased Toxicity Among Adolescents and Young Adults Compared with Children Hospitalized with Acute Lymphoblastic Leukemia at Children's Hospitals in the United States. J Adolesc Young Adult Oncol. 2021 Jan 28.

Gupta A, Liu H, Schieffer KM, Koo SC, Cottrell CE, Mardis ER, Roberts RD, Yeager ND. Targeted Therapy in a Young Adult With a Novel Epithelioid Tumor Driven by a PRRC2B-ALK Fusion. J Natl Compr Canc Netw. 2021 Oct 15.

Gupta A, Cripe TP. Immunotherapies for Pediatric Solid Tumors: A Targeted Update. Paediatr Drugs. 2021;1-12.

Gupta A, Taslim C, Tullius BP, Cripe TP. Therapeutic modulation of the CD47-SIRPα axis in the pediatric tumor microenvironment: working up an appetite. Cancer Drug Resist. 2020;3.