Zachary Stiles

Surgical Oncology

Cancers Treated:

Specializing In:

Minimally invasive surgery, Robotic surgery, Liver ablation, Vascular resection and reconstruction

Research Interests:

Pancreatic cancer treatment and outcomes, Optimal chemotherapy for hepatobiliary and gastrointestinal malignancies, Use of "big data" to shape our understanding of disease, Application and improvement of minimally invasive surgical approaches

About Zachary Stiles


I am a surgical oncologist with the Roswell Park Care Network. I focus on diseases of the hepatobiliary and gastrointestinal tracts, both malignant and benign.

I completed general surgery residency at the University of Tennessee Health Science Center (UTHSC), the largest academic medical network in Memphis, Tennessee. During residency I also completed a two-year research fellowship at the UTHSC Cancer Research Center focusing on the translational applications of mucin and micro-RNA expression in pancreatic cancer. In addition, I also obtained a Master's in Science in Epidemiology from the UTHSC College of Graduate Health Sciences. Following residency I then completed a fellowship in Complex General Surgical Oncology at Roswell Park Comprehensive Cancer Center.

My clinical research focuses on the application of minimally invasive approaches to complex oncologic operations and the use of large datasets to study disease and surgical outcomes.


Roswell Park Care Network
  • Surgical Oncologist
  • Hematology Oncology Southtowns
  • Care Network Member — Lockport


Education and Training:

  • 2017-2020 - MS - Epidemiology, University of Tennessee Health Science Center (UTHSC), Memphis, TN
  • 2010-2014 - DO - Lake Erie College of Osteopathic Medicine, Erie, PA


  • 2014-2021 - General Surgery, University of Tennessee Health Science Center (UTHSC), Memphis, TN


  • 2021-2023 - Complex General Surgical Oncology, Roswell Park Comprehensive Cancer Center/University of Rochester, Buffalo, NY

Board Certification:

  • General Surgery - American Board of Surgery

Professional Memberships:

  • Society of Surgical Oncology
  • American College of Surgeons
  • Americas Hepato-Pancreato-Biliary Association
  • Association for Academic Surgery

Featured on Cancer Talk


  • Nationwide Analysis of Unplanned Conversion During Minimally Invasive Distal Pancreatectomy for Pancreatic Adenocarcinoma. Stiles ZE, Tolley EA, Dickson PV, Deneve JL, Kocak M, Behrman SW. HPB (Oxford). 2023 Aug 22:S1365-182X(23)01903-2 doi: 10.1016/j.hpb.2023.08.009. PMID: 37652810
  • Relevance of Subcarinal Lymph Node Dissection for Gastroesophageal Junction Adenocarcinoma. Stiles ZE, Brady M, Hochwald SN, Kukar M. J Surg Res. 2023 Oct;290:2-8. doi: 10.1016/j.jss.2023.03.047. PMID: 37156029
  • Lymph Node Metastases in Gastrointestinal Stromal Tumors: an Uncommon Event. Stiles ZE, Fleming AM, Dickson PV, Tsao M, Glazer ES, Shibata D, Deneve JL. Ann Surg Oncol. 2022 Dec;29(13):8641-8648. doi: 10.1245/s10434-022-12582-1. PMID: 36197560
  • Long-Term Implications of Unplanned Conversion During Laparoscopic Liver Resection for Hepatocellular Carcinoma. Stiles ZE, Glazer ES, Deneve JL, Shibata D, Behrman SW, Dickson PV. Ann Surg Oncol. 2019 Jan;26(1):282-289. doi: 10.1245/s10434-018-7073-6. Epub 2018 Nov 19. PMID: 30456682
  • Transmembrane mucin MUC13 distinguishes intraductal papillary mucinous neoplasms from non-mucinous cysts and is associated with high-risk lesions. Stiles ZE, Khan S, Patton KT, Jaggi M, Behrman SW, Chauhan SC. HPB (Oxford). 2019 Jan;21(1):87-95. doi: 10.1016/j.hpb.2018.07.009. Epub 2018 Aug 14. PMID: 30115565 Free PMC article.
  • The impact of unplanned conversion to an open procedure during minimally invasive pancreatectomy. Stiles ZE, Dickson PV, Deneve JL, Glazer ES, Dong L, Wan JY, Behrman SW. J Surg Res. 2018 Jul;227:168-177. doi: 10.1016/j.jss.2018.02.028. Epub 2018 Mar 19. PMID: 29804849
  • Desmoplastic small round cell tumor: A nationwide study of a rare sarcoma. Stiles ZE, Dickson PV, Glazer ES, Murphy AJ, Davidoff AM, Behrman SW, Bishop MW, Martin MG, Deneve JL. J Surg Oncol. 2018 Jun;117(8):1759-1767. doi: 10.1002/jso.25071. Epub 2018 Jun 7. PMID: 29878371
  • Ampullary adenocarcinoma: Defining predictors of survival and the impact of adjuvant therapy following surgical resection for stage I disease. Stiles ZE, Behrman SW, Deneve JL, Glazer ES, Dong L, Wan JY, Martin MG, Dickson PV. J Surg Oncol. 2018 Jun;117(7):1500-1508. doi: 10.1002/jso.25021. Epub 2018 Mar 8. PMID: 29518820