Research Interests:
Bioinformatics Metabolism Immunology Data integration Data visualizationAbout Spencer Rosario
Biography:
I joined the faculty of the Biostatistics & Bioinformatics Department at Roswell Park Comprehensive Cancer Center as an Assistant Professor of Oncology in March 2021.
I began my training in bioinformatics at Georgetown University, where I received my Master's degree in Tumor Biology with a System's Biology focus, in 2014. I then came to Roswell Park in 2014 where I completed my PhD at the University at Buffalo Roswell Park division in the Molecular Pharmacology and Cancer Therapeutics program in April of 2020. I then continued as a postdoctoral research fellow in the Biostatistics & Bioinformatics departments, where I worked on understanding cancer and immune metabolism through a multi-omics integrative approach on several projects, spanning many disease sites.
In my professional career at Roswell Park, I have utilized my training and experience to drive my own and collaborative research projects. I have an interdisciplinary skillset, with expertise in cancer biology, genomics, metabolomics, and computational approaches for the understanding and visualization of high-throughput data. I have extensive experience coding in R, as well as in the design, implementation, integration and interpretation of the multi-omics data, and in particular how we can use this knowledge to better understand the complex metabolic landscape of the tumor, tumor microenvironment, and immune system.
Positions
- Assistant Professor of Oncology
- Department of Biostatistics & Bioinformatics
- Director, BMPK Shared Resource
Background
Education and Training:
- 2014-2020 - PhD - Molecular Pharmacology & Cancer Therapeutics, State University of New York at Buffalo, Roswell Park Division, Buffalo, NY
- 2013-2014 - MS - Tumor Biology/Systems Biology, Georgetown University, Washington, DC
Professional Memberships:
- Sigma Xi: Scientific Research Honor Society
- American Statistical Association (ASA)
- American Association for Cancer Research (AACR)
Professional Experience:
- 2020-2021 - Post-Doctoral Research Affiliate, Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY
Publications
Ku S*, Rosario S*, Wang Y, Mu P, Seshadri M, Goodrich ZW, Goodrich MM, Gomez EC, Wang J, Xu B, Sawyers CL, Ellis L, Goodrich DW. (2016) Rb1 and TrP52 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance. Science. 355(6320): 78-83. PMID: 28059767 *Equal contribution
Rosario SR, Long MD, Affronti HC, Eng KH, Smiraglia DJ. Pan-cancer in-silico analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas. (2018) Nature Communications. 9: 5330, doi: 10.1038/s41467-018-07232-8. PMID: 30552315
Long MD, Singh PK, Russell JR, Llimos G, Rosario S, Rizvi A, van den Berg PR, Kirk J, Sucheston-Campbell LE, Smiraglia DJ, Campbell MJ. The miR-96/RARy signaling axis governs androgen signaling and prostate cancer progression (2019) Oncogene. 38:3, 421-44 PMID: 30120411
Affronti HC, Rowsam AM, Pellerite AJ, Rosario SR, Jacobi JJ, Long MD, Bianchi-Smiraglia A, Boerlin CS, Gillard BM, Karasik E, Foster BA, Moser M, Wilton J, Attwood K, Nikiforov MA, Azabdaftari G, Pili R, Phillips J, Casero R, Smiraglia DJ. Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy. (2020) Nature Communications.11:1, 52. PMID: 31911608
Knudsen ES, Nambiar R, Rosario SR, Smiraglia DJ, Goodrich DW, Witkiewicz AK. Pan-cancer molecular analysis of the RB-Pathway. (2020) Commun Bio. 3:158, doi: 10.1038/s42003-020-0873-9. PMID: 32242058