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… Breast Cancer Laboratory research led by Dr. Anna Bianchi-Smiraglia reveals therapeutic target in metabolic enzyme … using drugs known as IMPDH2 inhibitors. Anna Bianchi-Smiraglia, PhD, led work that has identified a possible … time as a postdoctoral research affiliate in Dr. Bianchi-Smiraglia’s lab at Roswell Park, and Spencer Rosario, PhD , a …

… therapy are often short-lived. Dr. Dominic Smiraglia “Prostate cancer, even metastatic disease, responds … recur,” says co-senior author and study leader Dominic Smiraglia, PhD , Associate Professor of Oncology in the … Park, and Justine Jacobi, a predoctoral trainee in Dr. Smiraglia’s lab. This study was funded by the U.S. Department …

… pathway and the methionine salvage pathway.  Dominic Smiraglia, PhD , Associate Professor of Oncology in the … and clinicians with no more good options,” says Dr. Smiraglia. “This new metabolic approach is completely … any tissue, and this increases with prostate cancer,” Dr. Smiraglia notes. “This unique but normal state means …

… process pivotal for cancer cell invasion. Dr. Anna Bianchi-Smiraglia “The ability of cancer cells to invade is a prerequisite for metastasis,” says Anna Bianchi-Smiraglia, PhD , Assistant Professor of Oncology in the … locations to fuel cancer and metastasis,” says Dr. Bianchi-Smiraglia. “Disabling such interactions may provide a new …

… and personalized therapies. A research team led by Dominic Smiraglia, PhD , Associate Professor of Oncology in the … potential responders to metabolic therapeutics,” says Dr. Smiraglia, who is senior author of the study. “Our data … first author of the study and a doctoral student in Dr. Smiraglia’s lab. “The magnitude of distortion of a particular …

… the Department of Molecular and Cellular Biology, Dominic Smiraglia, PhD , Associate Professor of Oncology in the … genesis and spread of pancreatic islet-cell cancer. Dr. Smiraglia also received a two-year, $165,000 grant from the … the Department of Molecular and Cellular Biology, Dominic Smiraglia, PhD , Associate Professor of Oncology in the …

… development of novel prostate cancer therapies. Dominic Smiraglia, PhD , Associate Professor of Oncology in the … and unique metabolic stress that can be exploited. Dr. Smiraglia and colleagues will test a novel therapeutic … development of novel prostate cancer therapies. Dominic Smiraglia, PhD , Associate Professor of Oncology in the …

… signaling,” notes the paper’s first author, Anna Bianchi-Smiraglia, PhD, a postdoctoral researcher with the Department … signaling,” notes the paper’s first author, Anna Bianchi-Smiraglia, PhD, a postdoctoral researcher with the Department …

… from the NCI, to the paper’s first author, Anna Bianchi-Smiraglia, PhD, a postdoctoral researcher in Dr. Nikiforov’s … from the NCI, to the paper’s first author, Anna Bianchi-Smiraglia, PhD, a postdoctoral researcher in Dr. Nikiforov’s …

… Department of Pharmacology and Therapeutics, and Dominic Smiraglia, PhD , Associate Professor of Oncology, Department … Department of Pharmacology and Therapeutics, and Dominic Smiraglia, PhD , Associate Professor of Oncology, Department …