Cell Stress and Biophysical Therapies

Program Leaders

Co-Leader
Cell Stress and Biophysical Therapies CCSG Program
Anurag Singh, MD
Co-Leader
Cell Stress and Biophysical Therapies CCSG Program

The unifying theme of the Cell Stress and Biophysical Therapies Program is exploitation of oxidative and thermal stress as target mechanisms of therapies. The broad goals are:

  1. to develop novel cancer treatment strategies based on biophysical principles, especially light and heat.
  2. to understand their molecular and cellular mechanisms.
  3. to bring them to clinical fruition by facilitating interactions with clinicians and basic scientists in other Programs.
  4. to provide a training ground for these novel treatment approaches.

Roswell Park Comprehensive Cancer Center is the birthplace of clinical PDT and played a critical role in bringing this modality to FDA approval in 1998.The Institute also has had a long-standing strong presence in the field of thermal stress and several important heat shock genes have been cloned at Roswell Park.The Program member’s expertise and multidisciplinary research on photodynamic therapy, thermal therapy/heat shock proteins (hsp), tumor hypoxia and oxidative stress, radiation/oxidative DNA damage/repair, and membrane biophysics has resulted in three inter-related programmatic themes:

  1. Rational Treatment Design and Optimization of novel cancer therapies employing biophysical principles, primarily light and heat, but also including ionizing radiation
  2. Immune Modulation based on these therapies; and
  3. Molecular Mechanisms of Oxidative and Thermal Stress.

Program Members

Marina Antoch, PhD
Member
Cell Stress and Biophysical Therapies CCSG Program
Heinz Baumann, PhD
Member
Department of Molecular and Cellular Biology
David Bellnier, PhD
Member
Department of Cell Stress Biology
Subhamoy Dasgupta, PhD
Assistant Professor of Oncology
Department of Cell Stress Biology
Sandra Gollnick, PhD
Member
Department of Cell Stress Biology
Andrei Gudkov, PhD, DSci
Chair
Department of Cell Stress Biology
Professor of Oncology
Department of Cell Stress Biology
Wesley Hicks Jr., MD, FACS
Professor of Oncology
Department of Head & Neck/Plastic & Reconstructive Surgery
Eugene Kandel, PhD
Assistant Professor of Oncology
Department of Cell Stress Biology
John M. Kane III, MD, FACS
Chair
Department of Surgical Oncology
Minhyung Kim
Minhyung Kim
Affiliate Member
Department of Surgical Oncology
Moni Abraham Kuriakose, MD, FDSRCS, FFDRCS, FRCS Ed, FRCS, BDS
Professor of Oncology
Department of Head & Neck Surgery/Plastic & Reconstructive Surgery
Qian Liu-Portrait-headshot
Assistant Professor of Oncology
Department of Biostatistics & Bioinformatics
Mark Long, PhD
Assistant Professor of Oncology
Department of Biostatistics & Bioinformatics
Ravindra Pandey, PhD
Professor and Distinguished Member
Department of Cell Stress Biology
Gyorgy Paragh, MD, PhD
Assistant Member
Department of Cell Stress Biology
Saraswati Pokharel, MD, PhD
Assistant Professor of Oncology
Department of Pathology & Laboratory Medicine
Mukund Seshadri, DDS, PhD
Chair
Department of Oral Oncology
Gal Shafirstein, DSc, MSc, BSc
Professor of Oncology
Department of Cell Stress Biology
Anna Bianchi-Smiraglia, PhD
Assistant Professor of Oncology
Department of Cell Stress Biology
Dominic Smiraglia, PhD
Associate Professor of Oncology
Department of Cancer Genetics and Genomics
Joseph Spernyak, PhD
Co-director
Preclinical Imaging Facility and Imaging Research

Contact Person

Bruce Specht
Scientific Administrator
Tel: 716 845-1065
Fax: 716 845-8899
bruce.specht@roswellpark.org