Elizabeth Repasky

PhD

Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • Professor of Oncology
  • Department of Immunology
  • The Dr. William Huebsch Professorship in Immunology
  • Co-Leader, Cell Stress and Biophysical Therapies CCSG Program

Background

Education and Training:

  • PhD (Anatomy) - State University of New York at Buffalo, Buffalo, NY

Fellowship:

  • 1982 - Cell Biology - California Institute of Technology, Pasadena, CA

Professional Memberships:

  • American Association of Immunologists
  • American Association for Cancer Research
  • Cell Stress Society International
  • Society for Immunotherapy of Cancer
  • Society of Thermal Medicine
  • Radiation Research Society

Publications

Full Publications list on PubMed

Bankert RB, Umemoto T, Sugiyama Y, Chen FA, Repasky E, Yokota S. 1989. Human lung tumors, patients' peripheral blood lymphocytes and tumor infiltrating lymphocytes propagated in scid mice. Curr Top Microbiol Immunol 152: 201-10

Sakakibara T, Xu Y, Bumpers HL, Chen FA, Bankert RB, Arredondo MA, Edge SB, Repasky EA. 1996. Growth and metastasis of surgical specimens of human breast carcinomas in SCID mice. Cancer J Sci Am 2: 291-300

Xu Y, Silver DF, Yang NP, Oflazoglu E, Hempling RE, Piver MS, Repasky EA. 1999. Characterization of human ovarian carcinomas in a SCID mouse model. Gynecol Oncol 72: 161-70

Naka T, Sugamura K, Hylander BL, Widmer MB, Rustum YM, Repasky EA. 2002. Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. Cancer Res 62: 5800-6

Oflazoglu E, Elliott M, Takita H, Ferrone S, Henderson RA, Repasky EA. 2007. Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model. J Transl Med 5: 29

Mace TA, Zhong L, Kilpatrick C, Zynda E, Lee CT, Capitano M, Minderman H, Repasky EA. 2011. Differentiation of CD8+ T cells into effector cells is enhanced by physiological range hyperthermia. J Leukoc Biol 90: 951-62

Kokolus KM, Capitano ML, Lee CT, Eng JW, Waight JD, Hylander BL, Sexton S, Hong CC, Gordon CJ, Abrams SI, Repasky EA. 2013. Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature. Proc Natl Acad Sci U S A 110: 20176-81

Leigh ND, Kokolus KM, O'Neill RE, Du W, Eng JW, Qiu J, Chen GL, McCarthy PL, Farrar JD, Cao X, Repasky EA. 2015. Housing Temperature-Induced Stress Is Suppressing Murine Graft-versus-Host Disease through beta2-Adrenergic Receptor Signaling. J Immunol 195: 5045-54

Zynda ER, Grimm MJ, Yuan M, Zhong L, Mace TA, Capitano M, Ostberg JR, Lee KP, Pralle A, Repasky EA. 2015. A role for the thermal environment in defining co-stimulation requirements for CD4(+) T cell activation. Cell Cycle 14: 2340-54

Bucsek MJ, Qiao G, MacDonald CR, Giridharan T, Evans L, Niedzwecki B, Liu H, Kokolus KM, Eng JW, Messmer MN, Attwood K, Abrams SI, Hylander BL, Repasky EA. 2017. beta-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy. Cancer Res 77: 5639-51

Mohammadpour H, O'Neil R, Qiu J, McCarthy PL, Repasky EA, Cao X. 2018. Blockade of Host beta2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs. J Immunol 200: 2479-88

Qiao G, Bucsek MJ, Winder NM, Chen M, Giridharan T, Olejniczak SH, Hylander BL, Repasky EA. 2018. β-Adrenergic signaling blocks murine CD8+T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress. Cancer Immunol Immunother online Sept 18, 2018