Elizabeth Repasky, PhD
Elizabeth Repasky, PhD
Professor of Oncology
Department of Immunology
The Dr. William Huebsch Professorship in Immunology
Co-Leader, Cell Stress and Biophysical Therapies CCSG Program
Roswell Park Cancer Institute
Background
Education and Training:
PhD (Anatomy) - State University of New York at Buffalo, Buffalo, NY
Fellowship:
1982 - Cell Biology - California Institute of Technology, Pasadena, CA
Professional Memberships:
American Association of Immunologists
American Association for Cancer Research
Cell Stress Society International
Society for Immunotherapy of Cancer
Society of Thermal Medicine
Radiation Research Society
- Arnouk H, Zynda ER, Wang X-Y, Hylander BL, Manjili MH, Repasky EA, Subjeck JR, Latif Kazim A. Tumour secreted grp170 chaperones full-length protein substrates and induces an adaptive anti-tumour immune response in vivo. International journal of hyperthermia 2010; 26(4):366-375
- Lee C-T, MacE T, Repasky EA. Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?. International journal of hyperthermia 2010; 26(3):232-246
- Peer AJ, Grimm MJ, Zynda ER, Repasky EA. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. Immunologic research 2010; 46(1-3):137-154
- Wang XY, Sun X, Chen X, Facciponte J, Repasky EA, Kane J, Subjeck JR. Superior antitumor response induced by large stress protein chaperoned protein antigen compared with peptide antigen. Journal of immunology (Baltimore, Md. : 1950) 2010; 184(11):6309-6319
- Hong C-C, Kokolus K, Ambrosone C, Edge S, Kulkarni S, Repasky E. Body temperature and thermal discomfort among breast cancer survivors. Proceedings of the American Association for Cancer Research Annual Meeting 2010; 51:218
- Kokolus KM, Hong C-C, Repasky EA. Feeling too hot or cold after breast cancer: is it just a nuisance or a potentially important prognostic factor?. International journal of hyperthermia 2010; 26(7):662-680
- Sharma R, Buitrago S, Pitoniak R, Gibbs JF, Hylander BL, Repasky EA. Apo2L/TRAIL inhibits growth of patient pancreatic tumors in a metastasizing orthotopic xenograft SCID mouse model. Annals of surgical oncology 2010; 17(Suppl. 1):S25
- Katkere B , Rosa S , Caballero A , Repasky EA , Drake JR. Physiological-range temperature changes modulate cognate antigen processing and presentation mediated by lipid raft-restricted ubiquitinated B cell receptor molecules. Journal of immunology (Baltimore, Md. : 1950) 2010; 185(9):5032-5039
- Lesinski GB , Muthusamy N , Petros W , June CH , Lotze MT , Kalinski P , Wei W-Z , Repasky EA , Carson WE , Olencki T. Meeting report: The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TrC3); Immune Suppression and the Tumor Microenvironment, Columbus, Ohio; March 1-2, 2010. Journal of immunotherapy (Hagerstown, Md. : 1997) 2010; 33(7):659-662
- Bhattacharya A, Toth K, Sen A, Seshadri M, Cao S, Durrani FA, Faber E, Repasky EA, Rustum YM. Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor. Clinical colorectal cancer 2009; 8(3):155-162
- Bogner PN, Patnaik SK, Pitoniak R, Kannisto E, Repasky E, Hylander B, Yendamuri S, Ramnath N. Lung cancer xenografting alters microRNA profile but not immunophenotype. Biochemical and biophysical research communications 2009; 386(2):305-310
- Seshadri M, Merzianu M, Tang H, Rigual NR, Sullivan M, Loree TR, Popat SR, Repasky EA, Hylander BL. Establishment and characterization of patient tumor-derived head and neck squamous cell carcinoma xenografts. Cancer biology and therapy 2009; 8(23):2275-2283
- Skitzki JJ, Repasky EA, Evans SS. Hyperthermia as an immunotherapy strategy for cancer. Current opinion in investigational drugs (London, England : 2000) 2009; 10(6):550-558
- Hylander BL, Starling GC, Wilson K, Repasky EA, Chao D, Kim H, Choi D, Tanlimco S, Sho M, Culp PA. PDL192, a humanized antibody to TweakR exhibits potent anti-tumor activity in non-small cell lung cancer models. European journal of cancer (Oxford, England : 1990) 2010; 8(7):29
- Yi H, Yu X, Guo C, Manjili MH, Repasky EA, Wang X-Y. Adoptive cell therapy of prostate cancer using female mice-derived T cells that react with prostate antigens. Cancer immunology, immunotherapy : CII 2011; 60(3):349-360
- Beachy SH, Repasky EA. Toward establishment of temperature thresholds for immunological impact of heat exposure in humans. International journal of hyperthermia 2011; 27(4):344-352
- Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, Evans SS, Hylander BL, Repasky EA. Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer research 2011; 71(11):3872-3880
- Shao H, Tang H, Salavaggione OE, Yu C, Hylander B, Tan W, Repasky E, Adjei AA, Dy GK. Improved Response to nab-Paclitaxel Compared with Cremophor-Solubilized Paclitaxel is Independent of Secreted Protein Acidic and Rich in Cysteine Expression in Non-Small Cell Lung Cancer. Journal of thoracic oncology 2011; 6(6):998-1005
- Beachy SH, Repasky EA. Using extracellular biomarkers for monitoring efficacy of therapeutics in cancer patients: an update. Cancer immunology, immunotherapy : CII 2008; 57(6):759-775
- Capitano ML, Ertel BR, Repasky EA, Ostberg JR. Winner of the 2007 Society for Thermal Medicine Young Investigator Award. Fever-range whole body hyperthermia prevents the onset of type 1 diabetes in non-obese diabetic mice. International journal of hyperthermia 2008; 24(2):141-149
- Dayanc BE, Beachy SH, Ostberg JR, Repasky EA. Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses. International journal of hyperthermia 2008; 24(1):41-56
- McAllister SS, Repasky EA, Hylander BL, Harris LN, Reinhardt F, Ince TA, Saelzler MP, Kelleher SP, Greiner AL, Gifford AM, Weinberg RA. Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 2008; 133(6):994-1005
- Oflazoglu E, Stone IJ, Gordon K, Wood CG, Repasky EA, Grewal IS, Law CL, Gerber HP. Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker. Clinical cancer research 2008; 14(19):6171-6180
- Sugahara T, Watanabe M, Repasky EA, Ostapenko V, Leeper DB, Park HJ, Li G, Ohnishi T, Kondo M, Vujaskovic Z, Kampinga HH, van der Zee J, Song CW. Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final report. International journal of hyperthermia 2008; 24(2):123-140
- Sugamura K, Gibbs JF, Belicha-Villanueva A, Andrews C, Repasky EA, Hylander BL. Synergism of CPT-11 and Apo2L/TRAIL against two differentially sensitive human colon tumor xenografts. Oncology 2008; 74(3-4):188-197
- Beachy SH, Kisailus AJ, Repasky EA, Subjeck JR, Wang XY, Kazim AL. Engineering secretable forms of chaperones for immune modulation and vaccine development. Methods (San Diego, Calif.) 2007; 43(3):184-193
- Kowalczyk A, Ciesielski M, Brecher M, Fenstermaker R, Repasky E, Rokita H, Kaneko Y, Bambach B, Gil M, Wierzbicki A, Kozbor D. Induction of protective immune responses against NXS2 neuroblastoma challenge in mice by immunotherapy with GD2 mimotope vaccine and IL-15 and IL-21 gene delivery. Cancer immunology, immunotherapy : CII 2007; 56(9):1443-1458
- Oflazoglu E, Elliott M, Takita H, Ferrone S, Henderson RA, Repasky EA. Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model. Journal of translational medicine 2007; 5:29
- Ostberg JR, Dayanc BE, Yuan M, Oflazoglu E, Repasky EA. Enhancement of natural killer (NK) cell cytotoxicity by fever-range thermal stress is dependent on NKG2D function and is associated with plasma membrane NKG2D clustering and increased expression of MICA on target cells. Journal of leukocyte biology 2007; 82(5):1322-1331
- Wang XY, Facciponte J, Chen X, Subjeck JR, Repasky EA. Scavenger receptor-A negatively regulates antitumor immunity. Cancer research 2007; 67(10):4996-5002
- Xu Y, Choi J, Hylander B, Sen A, Evans SS, Kraybill WG, Repasky EA. Fever-range whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin. International journal of hyperthermia 2007; 23(6):513-527
- Repasky EA, Subjeck JR. Heat shock proteins and cancer therapy: the trail grows hotter!. Oncotarget 2011; 2(6):433-434
- Bansal H, Bansal S, Varadarajan P, Repasky E, Chanan-Khan A, Lee KP, Padmanabhan S. Interferons downregulate the expression of WT1 in myeloid leukemia through the JAK/STAT pathway and this potentiates chemotherapy induced apoptosis. Blood 2007; 110(11 Part 1):Abstract #2852
- Bansal S, Bansal H, Baris E, Repasky E, Chanan-Khan A, Lee KP, Padmanabhan S. WTI interaction with the chaperone protein HSP90 regulates its expression in myeloid leukemia. Blood 2007; 110(11 Part 1):Abstract #1826
- Capitano ML, Mace T, McCarthy P, Repasky E. Mild (fever-range) thermal stress increases the rate of granulocyte recovery and G-CSF production following non-myeloablative total body irradiation. Journal of immunotherapy (Hagerstown, Md. : 1997) 2007; 30(8):867-868
- Capitano ML, Schueckler JT, Jaggernauth W, Sen A, Repasky EA. Fever-range whole body hyperthermia increases the efficacy of radiation therapy by selectively increasing the percentage of perfused tumor blood vessels. Proceedings of the American Association for Cancer Research Annual Meeting 2008; 49:1371
- Vinjamaram S, Gibbs J, Khoury T, Repasky E, Hylander B, Iyer R. In vivo translational drug development model in pancreatic cancer. American journal of gastroenterology 2008; 103(Suppl. 1):S84 (Abstract #218)
- Yu C, Tang H, Friday B, Miner JN, Chapman MS, Repasky E, Adjei AA. Inhibition of MAPK signaling enhances Sorafenib-mediated cytoxicity in human cancer cells in vitro and in vivo. Proceedings of the American Association for Cancer Research Annual Meeting 2009; 50:892
- Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS. IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. Journal of clinical investigation 2011; 121(10):3846-3859
- Mace TA, Zhong L, Kilpatrick C, Zynda E, Lee CT, Capitano M, Minderman H, Repasky EA. Differentiation of CD8+ T cells into effector cells is enhanced by physiological range hyperthermia. Journal of leukocyte biology 2011; 90(5):951-962
- Qian J, Yi H, Guo C, Yu X, Zuo D, Chen X, Kane III JM, Repasky EA, Subjeck JR, Wang X-Y. CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma. Journal of immunology (Baltimore, Md. : 1950) 2011; 187(6):2905-2914
- Shao H, Gao C, Tang H, Zhang H, Roberts LR, Hylander BL, Repasky EA, Ma WW, Qiu J, Adjei AA, Dy GK, Yu C. Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo. Journal of hepatology 2012; 56(1):176-183
- Lee CT, Zhong L, Mace TA, Repasky EA. Elevation in body temperature to Fever range enhances and prolongs subsequent responsiveness of macrophages to endotoxin challenge. PloS one 2012; 7(1):e30077
- Capitano M, Lee C-T, Kokolus K, Repasky EA. Are laboratory mice too cold to mount effective anti-tumor immune responses?. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #790
- Capitano ML, Nemeth M, McCarthy P, Repasky EA. A novel warming strategy for improving neutrophil recovery following total body irradiation. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #575
- Hennon MW, Hylander B, Morrison C, Miller A, Groman A, Dexter E, Yendamuri S, Demmy TL, Adjei A, Reid M, Repasky E, Nwogu C. Predicting NSCLC outcomes based on tumor growth in SCID mice. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #1610
- Zhang H, Tang H, Shao H, Gao C, Hylander BL, Repasky EA, Dy GK, Ma WW, Yu C, Adjei AA. Mcl-1 downregulation plays a crucial role in the synergistic anticancer activities between PI-3 kinase inhibitors and histone deacetylase inhibitors in primary NSCLC tumors in vitro and in vivo. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #1
- Lee C-T, Repasky EA. How does temperature affect the function of tissue macrophages?. Proceedings of SPIE : Biomedical Optics and Medical Imaging 2011; 7901:79010H
- Srivatsan A, Rao KVR, Chen Y, Wang Y, Batt C, Morgan J, Sen A, Repasky E, Pandey RK. Effect of hyperthermia on PDT and imaging. Proceedings of SPIE : Biomedical Optics and Medical Imaging 2009; 7380:73805V