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New Ovarian Cancer Immunotherapy Study Poses Question: Can Microbiome Influence Treatment Response?

A new clinical study underway at Roswell Park Comprehensive Cancer Center is the first to test the combination of the immunotherapy pembrolizumab with two other drugs as treatment for recurrent epithelial ovarian cancer, and is also the first ovarian cancer clinical trial to incorporate analysis of patients’ microbiomes — the bacteria present in the human gut and other organs.

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Roswell Park Analysis: Risk Stratification Tool Accurately Predicts Prostate Cancer Progression

Predicting when prostate cancer is aggressive enough to warrant immediate treatment can be a challenge. Researchers at Roswell Park Cancer Institute have found that a particular prostate cancer nomogram accurately predicts the outcomes of prostate cancer patients and is a useful tool for informing treatment decisions. The findings have been published online ahead of print in the Journal of the National Comprehensive Cancer Network.
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Therapy Assessed in Roswell Park Preclinical Study May Facilitate, Simplify Regional Therapy for Melanoma

Melanoma is the fifth most common cancer in the U.S., and often recurs as multiple small tumors of the extremities. While these small tumors, called “in-transit” disease, can be treated through chemotherapy given directly to the affected limb, the standard for this focused or “regional” treatment has not been improved upon for more than 50 years. Preclinical research at Roswell Park Comprehensive Cancer Center demonstrates that the new anticancer drug CBL0137 is more effective than standard chemotherapy at killing melanoma tumor cells and was well tolerated in laboratory models. The study has been published online ahead of print in Cancer Research, a journal of the American Association for Cancer Research.
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For Women with Breast Cancer, Higher Vitamin D Levels Associated with Improved Survival

A new study adds to the evidence that vitamin D can help fight some forms of cancer. The study, which was led by researchers at Roswell Park Comprehensive Cancer Center and Kaiser Permanente, shows that women with higher levels of vitamin D when diagnosed with breast cancer experienced longer cancer-free survival and were about 30% less likely to die from the disease.

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While Side Effects from Immunotherapy Remain Rare, It’s Important to Spot Them Quickly

Immunotherapy, which uses the body’s own immune system to fight disease, is transforming the treatment of several types of cancers. Severe adverse effects can result from these groundbreaking cancer treatments, however, and when they do, it’s important to recognize and quickly address them, researchers write in the New England Journal of Medicine.