Dr. Leonid Cherkassky Leonid Cherkassky, MD

Leonid Cherkassky

Surgical Oncology

Specializing In:

Immunotherapy Liver Surgery, including resection of colorectal liver metastases Pancreatic Surgery Bile duct Surgery Gastric Surgery Colorectal Surgery Adrenal Surgery

Special Interests:

T cell immunotherapy Laparoscopic and robotic liver, bile duct, and pancreatic surgery Improving rates of surgical resection for patients with metastatic colorectal cancer

About Leonid Cherkassky


I am a surgical oncologist who specializes in treating patients with gastrointestinal benign and cancerous disease, with a special focus on liver, bile duct, gallbladder, pancreas, and colorectal cancer. I feel privileged to work in concert with the dynamic team here at Roswell Park composed of members from medical oncology, radiation oncology, pathology, gastroenterology and radiology. Together, our philosophy is to work as a team to discuss all aspects of a patient’s care to ensure the best possible treatment for every person. My personal role is to provide experienced surgical care to maximize the number of patients who benefit from resecting these tumors and to provide minimally invasive laparoscopic and robotic approaches whenever possible to allow faster patient recovery. I pride myself in providing each patient with the utmost attention to detail and giving care in a speedy, efficient way to ease anxiety and optimize outcomes.

In addition to caring for patients, I conduct laboratory and translational research within the Center for Immunotherapy and have been tasked with the development of immunotherapies for the treatment of pancreas, liver, and bile duct cancers. Even when these cancers are able to be surgically removed, there is often disease that has spread that leads to the cancer coming back. T cells are highly specialized immune cells that protect us from infections and cancers. I specialize in engineering T cells to target and kill cancers. T cell immunotherapy can be especially effective since it is a ‘living drug’ that can circulate throughout our bodies and treat any cancer that has already spread. My ultimate goal then is to combine surgery with immunotherapy to both remove the tumor and treat any disease that has already spread to prevent cancer from coming back to increase cancer survivors. I am excited to be at Roswell Park, an ideal place to combine my passions for taking care of cancer patients and developing effective immune therapies.


Roswell Park Comprehensive Cancer Center
  • Assistant Professor of Oncology
  • Department of Surgical Oncology
  • Center for Immunotherapy


Education and Training:

  • 2004-2009 - MD - Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio


  • 2009-2017 - General Surgery, Brown University, Providence, RI


  • 2011-2014 - Research fellowship, T cell immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY
  • 2017-2019 - Clinical fellowship, Complex General Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY

Board Certification:

  • 2018 - Board Certified General Surgery

Professional Memberships:

  • Society of Surgical Oncology (SSO)
  • American College of Surgeons

Honors & Awards:

  • 2019 Young Investigator Award, Conquer Cancer Foundation/American Society of Clinical Oncology
  • 2016 Cover of Journal of Clinical Investigation T cell therapy to treat solid tumors
  • 2012 American College of Surgeons Resident Research Scholarship
  • 2008 American Society of Nephrology Student Scholar Grant

Featured on Cancer Talk


Full Publications list on PubMed
  • Cherkassky L, D'Angelica M. Gallbladder Cancer: Managing the Incidental Diagnosis. Surg Oncol Clin N Am. 2019 Oct;28(4):619-630. doi: 10.1016/j.soc.2019.06.005. PMID: 31472909.
  • Cherkassky L, Jarnagin W. Selecting treatment sequence for patients with incidental gallbladder cancer: a neoadjuvant approach versus upfront surgery. Updates Surg. 2019 Jun;71(2):217-225. doi: 10.1007/s13304-019-00670-z. Epub 2019 Jun 28. PMID: 31254234.
  • Cherkassky L, Morello A, Villena-Vargas J, Feng Y, Dimitrov DS, Jones DR, Sadelain M, Adusumilli PS. Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J Clin Invest. 2016 Aug 1;126(8):3130-44. doi: 10.1172/JCI83092. Epub 2016 Jul 25. PMID: 27454297; PMCID: PMC4966328.
  • Adusumilli PS, Cherkassky L, Villena-Vargas J, Colovos C, Servais E, Plotkin J, Jones DR, Sadelain M. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med. 2014 Nov 5;6(261):261ra151. doi: 10.1126/scitranslmed.3010162. PMID: 25378643; PMCID: PMC4373413.
  • Cherkassky L, Lanning M, Lalli PN, Czerr J, Siegel H, Danziger-Isakov L, Srinivas T, Valujskikh A, Shoskes DA, Baldwin W, Fairchild RL, Poggio ED. Evaluation of alloreactivity in kidney transplant recipients treated with antithymocyte globulin versus IL-2 receptor blocker. Am J Transplant. 2011 Jul;11(7):1388-96. doi: 10.1111/j.1600-6143.2011.03540.x. Epub 2011 May 12. PMID: 21564525; PMCID: PMC3226763.

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