Trainees' Accomplishments and Highlights

OICO Education Program - Lab
OICO Education program - student working in lab
OICO Education Program - student with microscope

OICO has provided training to health care professionals, medical students and medical graduates from many different cultures.

OICO values each trainee and the diverse perspective they bring to our program. Each OICO trainee's passions and experiences are unique, which transpire into the research that they perform. We have selected some recent publications from our current trainees at Roswell Park, highlighting their research interests and chosen career fields.

  • Li F, Aljahdali IAM, Zhang R, Nastiuk KL, Krolewski JJ, Ling X. Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma. J Exp Clin Cancer Res. 2021 Aug 12;40(1):254. doi: 10.1186/s13046-021-02026-1. PMID: 34384473; PMCID: PMC8359575.
  • Thangaiyan R, Aljahdali IA, Lent-Moore KY, Liao J, Ling X, Li F. Kras mutation subtypes distinctly affect colorectal cancer cell sensitivity to FL118, a novel inhibitor of survivin, Mcl-1, XIAP, cIAP2 and MdmX. Am J Transl Res. 2021 Jul 15;13(7):7458-7474. PMID: 34377229; PMCID: PMC8340187.
  • Zonneville J, Wang M, Alruwaili MM, Smith B, Melnick M, Eng KH, Melendy T, Park BH, Iyer R, Fountzilas C, Bakin AV. Selective therapeutic strategy for p53-deficient cancer by targeting dysregulation in DNA repair. Commun Biol. 2021 Jul 12;4(1):862. doi: 10.1038/s42003-021-02370-0. PMID: 34253820; PMCID: PMC8275734.
  • Venkat S, Alahmari AA, Feigin ME. Drivers of Gene Expression Dysregulation in Pancreatic Cancer. Trends Cancer. 2021 Jul;7(7):594-605. doi: 10.1016/j.trecan.2021.01.008. Epub 2021 Feb 19. PMID: 33618999; PMCID: PMC8217125.
  • Alqassim EY, Sharma S, Khan ANMNH, Emmons TR, Cortes Gomez E, Alahmari A, Singel KL, Mark J, Davidson BA, Robert McGray AJ, Liu Q, Lichty BD, Moysich KB, Wang J, Odunsi K, Segal BH, Baysal BE. RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization. Commun Biol. 2021 Jan 22;4(1):102. doi: 10.1038/s42003-020-01620-x. PMID: 33483601; PMCID: PMC7822933.
  • Santha S, Ling X, Aljahdali IAM, Rasam SS, Wang X, Liao J, Wang J, Fountzilas C, Li Q, Qu J, Li F. Mutant Kras as a Biomarker Plays a Favorable Role in FL118-Induced Apoptosis, Reactive Oxygen Species (ROS) Production and Modulation of Survivin, Mcl-1 and XIAP in Human Bladder Cancer. Cancers (Basel). 2020 Nov 18;12(11):3413. doi: 10.3390/cancers12113413. PMID: 33217967; PMCID: PMC7698790.
  • Badawy AA, El-Magd MA, AlSadrah SA, Alruwaili MM. Altered expression of some miRNAs and their target genes following mesenchymal stem cell treatment in busulfan-induced azoospermic rats. Gene. 2020 May 5;737:144481. doi: 10.1016/j.gene.2020.144481. Epub 2020 Feb 15. PMID: 32070749.
  • Venkat S, Tisdale AA, Schwarz JR, Alahmari AA, Maurer HC, Olive KP, Eng KH, Feigin ME. Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma. Genome Res. 2020 Mar;30(3):347-360. doi: 10.1101/gr.257550.119. Epub 2020 Feb 6. PMID: 32029502; PMCID: PMC7111527.
  • Li F, Aljahdali I, Ling X. Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study? J Exp Clin Cancer Res. 2019 Aug 22;38(1):368. doi: 10.1186/s13046-019-1362-1. PMID: 31439015; PMCID: PMC6704566.
  • El-Magd MA, Khalifa SF, A Alzahrani FA, Badawy AA, El-Shetry ES, Dawood LM, Alruwaili MM, Alrawaili HA, Risha EF, El-Taweel FM, Marei HE. Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells. Biomed Pharmacother. 2018 Sep;105:813-823. doi: 10.1016/j.biopha.2018.06.014. Epub 2018 Jun 15. PMID: 29913410.
  • Alahmari AA, Sreekumar B, Patel V, Ashat M, Alexandre M, Uduman AK, Akinbiyi EO, Ceplenski A, Shugrue CA, Kolodecik TR, Tashkandi N, Messenger SW, Groblewski GE, Gorelick FS, Thrower EC. Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice. PLoS One. 2018 Jun 5;13(6):e0197362. doi: 10.1371/journal.pone.0197362. PMID: 29870540; PMCID: PMC5988302.
  • Nesher E, Safina A, Aljahdali I, Portwood S, Wang ES, Koman I, Wang J, Gurova KV. Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs. Cancer Res. 2018 Mar 15;78(6):1431-1443. doi: 10.1158/0008-5472.CAN-17-2690. Epub 2018 Jan 16. PMID: 29339544; PMCID: PMC5856628.
  • Monir, R., Badawy, A., Mokhtar, N., Nabil, H., Alruwaili, M. (2017). ABCA1 gene polymorphism and oxidative stress in polycystic ovary syndrome: Role of antioxidant therapy for prevention and control. Bulletin of Egyptian Society for Physiological Sciences, 37(2), 143-153. doi: 10.21608/besps.2017.8244
  • Limoge M, Safina A, Truskinovsky AM, Aljahdali I, Zonneville J, Gruevski A, Arteaga CL, Bakin AV. Tumor p38MAPK signaling enhances breast carcinoma vascularization and growth by promoting expression and deposition of pro-tumorigenic factors. Oncotarget. 2017 Jun 28;8(37):61969-61981. doi: 10.18632/oncotarget.18755. PMID: 28977919; PMCID: PMC5617479.
  • Andrei Bakin, Justin Zonneville, Moyi Wang, Mohammed Alruwaili, Kevin Eng, Renuka Iyer, Ben Park, Christos Fountzilas. A synthetic lethality treatment strategy for p53 mutant breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-16-07.
  • Othman, R. Q.A., Badawy, A. A., Alruwaili, M. M., Elmagd, M. A, Camel Milk Exosomes Potentiate The Anticancer Effect of Doxorubicin on Multidrug-Resistant Human Leukemia Hl60 Cells in Vitro and in Vivo. Pakistan Journal of Medicine and Health Sciences, 2021.
  • Abdulrahman A. Alahmari, Carla Schwarz, Emily Paterson, Swati Venkat, Arwen Tisdale, Michael E. Feigin. CPSF3 inhibition halts pancreatic cancer cell proliferation by limiting core histone supplies [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-034.
  • Abigail C. Cornwell, Abdulrahman A. Alahmari, Arwen A. Tisdale, Kathryn Maraszek, Swati Venkat, Michael E. Feigin. Lorazepam promotes desmoplasia and ischemic necrosis in murine pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-100.
  • Feigin, M., and A. Alahmari. "CPSF3 as a Novel Therapeutic Target in Pancreatic Cancer." In PANCREAS, vol. 50, no. 7, pp. 1058-1058. Two commerce sq, 2001 market st, philadelphia, pa 19103 usa: lippincott williams & wilkins, 2021.
  • Justin Zonneville, Moyi Wang, Mohammed Alruwaili, Kevin Eng, Thomas Melendy, Ben Ho Park, Renuka Iyer, Christos Fountzilas, Andrei V. Bakin. A novel synthetic lethality treatment strategy for metastatic breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1180.
  • Abigail C. Cornwell, Abdulrahman A. Alahmari, Arwen A. Tisdale, Michael E. Feigin. Lorazepam modifies the pancreatic ductal adenocarcinoma tumor microenvironment [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr PO-047.
  • Elimelech Nesher, Alfiya Safina, Ieman Aljahdali, Scott Portwood, Eunice Wang, Jianmin Wang, Igor Koman, Katerina Gurova. Chromatin trapping is a key factor for anticancer cytotoxicity of DNA-binding small molecule drugs [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1755.