Available Clinical Trials

Clinical Trials

Cancer Type or Disease

To inquire about participating in these studies, call 1-800-ROSWELL (1-800-767-9355). E-mail: askroswell@roswellpark.org

MATCH Treatment Subprotocol Z1K: Ipatasertib in Patients with Tumors with AKT Mutations

Principal Investigator: Levine, Ellis G

A Registry of Complementary/Alternative Medicine (CAM) Services (Intended for Correlation with Pediatric Cancer and Non-Malignant Hematological Disorders Clinical Symptoms)

Principal Investigator: Kelly, Kara M

NRG-BR004, "A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab with Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer," (NCT03199885)

Principal Investigator: Levine, Ellis G

Does increased mobility assessed with 3D motion tracking technology lead to early post-operative recovery among patients undergoing genitourinary surgeries

Principal Investigator: Guru, Khurshid

(S1900) A Master protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (LungMap screening Study

Principal Investigator: Chen, Hongbin

EA3163:Phase II randomized trial of neo-adjuvant chemotherapy followed by surgery and post-operative radiation versus surgery and post-operative radiation for organ preservation of T3 and T4a nasal and paranasal sinus squamous cell carcinoma (NPNSCC)

Principal Investigator: Singh, Anurag K

(COG ACNS1721) A Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High Grade Glioma (HGG) without H3K27M or BRAFV600E Mutations

Principal Investigator: Twist, Clare J

(S1801) A Phase II Randomized Study of Adjuvant Versus Neoadjuvant MK-3475 (Pembrolizumab) for Clinically Detectable Stage III-IV High Risk Melanoma

Principal Investigator: Ernstoff, Marc S

Palliative Management of Inoperable Malignant Bowel Obstruction: A Prospective, Open Label, Phase-2 Study at an NCI Comprehensive Cancer Center

Principal Investigator: Case, Amy A

(A041702) A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (= 70 Years of Age)With Chronic Lymphocytic Leukemia

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

A Phase 3 Study Comparing Daratumumab, VELCADE (bortezomib), Lenalidomide, and Dexamethasone (D-VRd) vs VELCADE, Lenalidomide, and Dexamethasone (VRd) in Subjects with Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not...

Principal Investigator: Hillengass, Jens

(SWOG S1815) A Phase III Randomized Trial of Gemcitabine, Cisplatin, and NAB-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers

Principal Investigator: Iyer, Renuka V

Phase 2 Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) with Pembrolizumab, in Subjects Who Have Failed Cisplatin-based Chemotherapy with Locally Advanced (Unresectable) or Metastatic Transitional Cell Cancer (TCC) of the Urothelium

Principal Investigator: Chatta, Gurkamal S

A Phase 2 Study of Sitravatinib in Combination with Nivolumab in Patients with Advanced or Metastatic Urothelial Carcinoma

Principal Investigator: Chatta, Gurkamal S

A Phase 1 Study with Expansion Cohorts to Assess the Safety, Tolerability, and Activity of Eribulin ORA (HM30181A + Eribulin) in Subjects with Solid Tumors

Principal Investigator: Gandhi, Shipra

(ALKS 4230-001) A Phase 1 Study of ALKS 4230 Administered Subcutaneously as Monotherapy and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Principal Investigator: Ernstoff, Marc S

(EDDOP NCI 10089) A Randomized Phase 2 Study of CDX-1127 (Varlilumab) in Combination with Nivolumab in Patients with Relapsed or Refractory Aggressive B-cell Lymphomas

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

Managed Access Program (MAP) to provide access to CTL019, for acute lymphoblastic leukemia (ALL) or diffuse large b-cell lymphoma (DLBCL) patients with out of specification leukapheresis product and/or manufactured tisagenlecleucel out of specification...

Principal Investigator: McCarthy, Philip L

(ALTE16C1) Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma

Principal Investigator: Rokitka, Denise A

(19244); REFINE: Regorafenib observational study in hepatocellular carcinoma

Principal Investigator: Iyer, Renuka V

(GMI-1271-301) A Phase III Randomized, Double-Blind Trial to Evaluate the Efficacy of Uproleselan Administered with Chemotherapy versus Chemotherapy Alone in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Principal Investigator: Przespolewski, Amanda C

A Phase 1 Study of Oral LOXO-292 in Patients with Advanced Solid Tumors, Including RET-Fusion Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, and Other Tumors with Increased RET Activity

Principal Investigator: Dy, Grace K

(NRG-DT001) A Phase IB Trial Of Neoadjuvant AMG 232 Concurrent With Preoperative Radiotherapy In Wild-Type P53 Soft Tissue Sarcoma (STS)

Principal Investigator: Kane, John M

Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Principal Investigator: Chatta, Gurkamal S

Impact of a National Comprehensive Cancer Network Compliant Multidisciplinary Consortium on Treatment Decisions in Patients with Localized Prostate Cancer

Principal Investigator: Guru, Khurshid

Phase 1/1b Open-Label, Dose-Escalation Study of APVO436 in Patients with Relapsed or Refractory AML or High-Grade MDS

Principal Investigator: Wang, Eunice S

A Phase 3, Randomized, Open-label, Multicenter Study Comparing Ponatinib versus Imatinib, Administered in Combination with Reduced-intensity Chemotherapy, in Patients with Newly Diagnosed Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia ...

Principal Investigator: Wang, Eunice S

Comparing Unilateral and Bilateral Deep Inferior Epigastric Perforators (DIEP) Flaps for unilateral breast reconstruction

Principal Investigator: Moon, Wong K

(NRG-GY017) Anti PD-L1 (Atezolizumab) as an Immune Primer and Concurrently with Extended Field Chemoradiotherapy for Node Positive Locally Advanced Cervical Cancer

Principal Investigator: Lele, Shashikant B

The Impact of Financial Distress on Prostate Cancer Treatment: A Feasibility Study

Principal Investigator: Sumlin, Adam B

(A171601) A PHASE II TRIAL ASSESSING THE TOLERABILITY OF PALBOCICLIB IN COMBINATION WITH LETROZOLE OR FULVESTRANT IN PATIENTS AGED 70 AND OLDER WITH ESTROGEN RECEPTOR-POSITIVE, HER2-NEGATIVE METASTATIC BREAST CANCER

Principal Investigator: O'Connor, Tracey L

A Phase 2 Study of INCMGA00012 in Participants With Metastatic Merkel Cell Carcinoma

Principal Investigator: Puzanov, Igor

Health Promotion in African American Cancer Survivors: Pilot Implementation Research (National Witness Project® Witness Role Models Use Precision Nutrition)

Principal Investigator: Devonish, Julia A

A novel parenting skills intervention to improve medication adherence in pediatric cancer

Principal Investigator: Bouchard, Elizabeth G

A Phase 1b, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of Camidanlumab Tesirine (ADCT-301) in Patients With Selected Advanced Solid Tumors

Principal Investigator: Puzanov, Igor

(S1712) A Randomized Phase II Study of Ruxolitinib (NSC-752295) in Combination with BCR-ABL Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia (CML) Patients with Molecular Evidence of Disease

Principal Investigator: Thompson, J E

(S1802) Phase III Randomized Trial of Standard Systemic Therapy (SST) versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

Principal Investigator: Chatta, Gurkamal S

Phase 1, Multicenter, Open-Label Study of the Antibody-Drug Conjugate TRPH-222 in Subjects with Relapsed and/or Refractory B Cell Lymphoma

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

(CITN-14) Randomized Phase II study of Atezolizumab (MPDL3280A) plus Recombinant Human IL-7 (CYT107) in patients with locally advanced or metastatic urothelial carcinoma

Principal Investigator: Chatta, Gurkamal S

Enhancing a home-based walking intervention among breast cancer survivors with rTMS: Feasibility and limited efficacy testing

Principal Investigator: Sheffer, Christine E

(EA2165) A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer

Principal Investigator: Boland, Patrick M

(S1706) A Phase II Randomized Trial of Olaparib (NSC-747856) Administered Concurrently with Radiotherapy versus Radiotherapy Alone for Inflammatory Breast Cancer

Principal Investigator: Fung-Kee-Fung, Simon

A Phase 1b/2 Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of Oleclumab (MEDI9447) with or without Durvalumab in Combination with Chemotherapy in Subjects with Metastatic Pancreatic Ductal Adenocarcinoma

Principal Investigator: Fountzilas, Christos

A Phase I Study of pevonedistat (MLN4924, TAK924) in combination with ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia and non-Hodgkin lymphoma

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

A Phase II Open Label, Study of IMMU-132 in Metastatic Urothelial Cancer After Failure of Platinum Based Regimen or Anti-PD-a/ PD-L1 Based Immunotherapy

Principal Investigator: George, Saby

A Phase IB/2 Study to Evaluate Safety and Anti-Tumor Activity of Avelumab in Combination with the Poly (Adenosine Diphosphate [ADP]-Ribose) Polymerase (PARP) Inhibitor Talazoparib in Patients with Locally Advanced or Metastatic Solid Tumors

Principal Investigator: Fountzilas, Christos

A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors (POD1UM-102)

Principal Investigator: Fountzilas, Christos

A Phase II Study of Palbociclib (PD-0332991) in Combination with Ibrutinib in Patients with Previously Treated Mantle Cell Lymphoma

Principal Investigator: Torka, Pallawi

A Phase 1/2, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 510 Monotherapy in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation and AMG 510 Combination Therapy in Subjects With...

Principal Investigator: Dy, Grace K

Phase Ib/II Study of Enzalutamide with Venetoclax (ABT-199) in Patients with Metastatic Castrate Resistant Prostate Cancer (mCRPC)

Principal Investigator: Chatta, Gurkamal S

A randomized phase II study to evaluate efficacy of TDM1with or without Palbociclib in the treatment of patients with metastatic HER2 positive breast cancer

Principal Investigator: Gandhi, Shipra

Nutrition and Exercise Interventions to Reduce Androgen Deprivation Therapy-induced Obese Frailty in Survivors of Advanced Prostate Cancer

Principal Investigator: Chatta, Gurkamal S

(A021602) RANDOMIZED, DOUBLE-BLINDED PHASE III STUDY OF CABOZANTINIB VERSUS PLACEBO IN PATIENTS WITH ADVANCED NEUROENDOCRINE TUMORS AFTER PROGRESSION ON EVEROLIMUS (CABINET)

Principal Investigator: Iyer, Renuka V

A Phase 1b (Open-Label) / Phase 2 (Randomized, Double-Blinded) Study Evaluating Nab-Paclitaxel and Gemcitabine With or Without Olaratumab in the Treatment of First-Line Metastatic Pancreatic Cancer

Principal Investigator: Fountzilas, Christos

(A061202) A Phase I/II Study of Pomalidomide, Dexamethasone and Ixazomib Vs. Pomalidomide and Dexamethasone for Patients with Multiple Myeloma Relapsing on Lenalidomide as Part of First Line Therapy

Principal Investigator: Hillengass, Jens

A Global Randomized Multicenter Phase 3 Trial to Compare the Efficacy and Safety of JCAR017 to Standard of Care in Adult Subjects with High-Risk, Transplant-Eligible Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphomas (TRANSFORM)

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

Flavored Tobacco Product Regulation: Behavioral Economic Demand, Visual Attention, and Flavored Tobacco Product Availability

Principal Investigator: Quisenberry, Amanda J

Preoperative Respiratory Muscle Training to Prevent Postoperative Pulmonary Complications in Patients Undergoing Resection for Lung Cancer

Principal Investigator: Yendamuri, Sai S

CONNECT (Clinical Outcomes of Nationwide, Naturalistic E-Cig Trial)

Principal Investigator: Goniewicz, Maciej L

(NCI 9673) Part B: A Multi-Institutional Phase 2 Study of Nivolumab or Nivolumab in Combination with Ipilimumab in Refractory Metastatic Squamous Cell Carcinoma of the Anal Canal (Amendment)

Principal Investigator: Boland, Patrick M

Phase 2 Study of Nanoliposomal Irinotecan with Fluorouracil and Leucovorin in Refractory Advanced High Grade Neuroendocrine Cancer of GI, Unknown or Pancreatic Origin

Principal Investigator: Iyer, Renuka V

Effects of filter ventilation on sensory response, smoking topography, and inhalation (COMET 2 2.1)

Principal Investigator: O'Connor, Richard J

Aromatherapy: An Integrative Option for Symptom Management in Cancer Care

Principal Investigator: Rokitka, Denise A

Enhancing infrastructure for Native American and Rural Cancer Control Research Capacity at Roswell Park Comprehensive Cancer Center

Principal Investigator: Bouchard, Elizabeth G

(ACCL1633) The Effectiveness of Lactobacillus plantarum in Preventing Acute Graft-versus-Host Disease (GvHD) in Children undergoing Alternative Hematopoietic Progenitor Cell Transplantation (HCT)

Principal Investigator: Bambach, Barbara J

(COG AHEP1531) Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT)

Principal Investigator: Twist, Clare J

A Randomized, Multi-Center Phase 2 Trial with a Phase 1 Safety Run-in: Porfimer Sodium Mediated Interstitial Photodynamic Therapy and Standard of Care (SoC) Therapy versus SoC Therapy alone for the Treatment of Patients with Locally Advanced or...

Principal Investigator: Arshad, Hassan

Enhancing Relapse Prevention with rTMS: Dose-Response Parameters for Smoking Cessation

Principal Investigator: Sheffer, Christine E

Changes in respiratory symptoms and inflammation markers among e-cigarette users during spontaneous "switching" between flavors (CRoFT_3.1)

Principal Investigator: Goniewicz, Maciej L

A PHASE 1/1B MULTICENTER STUDY TO EVALUATE THE HUMANIZED ANTI-CD 73 ANTIBODY, CPI-006, AS A SINGLE AGENT, IN COMBINATION WITH CPI-444, AND IN COMBINATION WITH PEMBROLIZUMAB IN ADULT SUBJECTS WITH ADVANCED CANCERS

Principal Investigator: Puzanov, Igor

Matched Targeted Therapy (MTT) Recommendation for Patients with Recurrent, Refractory, or High Risk Leukemias and Myelodysplastic Syndrome

Principal Investigator: Barth, Matthew J

Exercise and Nutrition Intervention in Older Breast Cancer Survivors

Principal Investigator: O'Connor, Tracey L

Effects of Physical Distraction and Music on Anxiety during Wide Local Excision

Principal Investigator: Schierer, Shirley

(S1602) A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming with Intradermal BCG Before Intravesical Therapy for BCG-Naïve High-Grade Non-Muscle Invasive Bladder Cancer

Principal Investigator: Li, Qiang J

Phase II trial of Concurrent Nivolumab in UroThelial Bladder Cancer with Radiation Therapy in Localized/Locally Advanced Disease for Chemotherapy Ineligible Patients [NUTRA]

Principal Investigator: George, Saby

A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial of Adjuvant Avelumab (Anti-PDL-1 antibody) in Merkel Cell Carcinoma Patients with Clinically Detected Lymph Node Metastases (Adjuvant Avelumab in MCC (ADAM) Trial

Principal Investigator: Ernstoff, Marc S

A Multicenter Phase II Study of Vaccines to Prevent Recurrence in Patients with HER-2 Positive Breast Cancer

Principal Investigator: Gandhi, Shipra

(CA-ALT-803-02-17) QUILT-3.055: A Phase IIb, Single-Arm, Open-Label Study of ALT-803 in Combination with Pembrolizumab or Nivolumab in Patients with Advanced or Metastatic Non-Small Cell Lung Cancer who have Disease Progression Following an Initial...

Principal Investigator: Yau, Edwin H

Understanding the relationship of caregiver stress to perceived preparedness for prescribed tasks and responsibilities caring for patients undergoing Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy (CS+HIPEC)

Principal Investigator: Stewart, Erika S

Photoacoustic Imaging of Human Breast

Principal Investigator: Bonaccio, Ermelinda

MATCH Treatment Subprotocol Z1H: Phase II Study of Copanlisib in Patients with Tumors with Deleterious PTEN Sequencing Result and PTEN Expression by IHC

Principal Investigator: Levine, Ellis G

MATCH Treatment Subprotocol Z1G: Phase II Study of Copanlisib in Patients with Tumors with PTEN Loss by IHC and any PTEN Sequencing Result

Principal Investigator: Levine, Ellis G

(ANBL1531) A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma

Principal Investigator: Twist, Clare J

A Phase 1/2a Study of BMS-986179 Administered Alone and in Combination with Nivolumab (BMS-936558) in Subjects with Advanced Solid Tumors

Principal Investigator: Ernstoff, Marc S

(NRG-GY007) A Phase I/II Study of Ruxolitinib with Front-Line Neoadjuvant and Post-Surgical Therapy in Patients with Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Principal Investigator: Lele, Shashikant B

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study Comparing CB-839 in Combination with Cabozantinib (CB-Cabo) vs. Placebo with Cabozantinib (Pbo-Cabo) in Patients with Advanced or Metastatic Renal Cell Carcinoma

Principal Investigator: George, Saby

Pilot Open Label Clinical Trial Evaluating the Safety and Efficacy of Chemokine Modulation to Enhance the Effectiveness of Pembrolizumab in Patients with Metastatic Triple Negative Breast Cancer

Principal Investigator: Opyrchal, Mateusz

Evaluation of Roswell Park Cessation Services

Principal Investigator: Sheffer, Christine E

ProSTAR: A Phase 1b/2 Study of CPI-1205, a Small Molecule Inhibitor of EZH2, Combined with Enzalutamide or Abiraterone/Prednisone in Patients with Metastatic Castration Resistant Prostate Cancer

Principal Investigator: Chatta, Gurkamal S

Strengthening knowledge for future generations: Cancer bio-banks in the landscapes of the Haudenosaunee

Principal Investigator: Haring, Rodney C

A Phase 2 Study of Poziotinib in Patients with Non-Small Cell Lung Cancer (NSCLC), Locally Advanced or Metastatic, with EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20)

Principal Investigator: Dy, Grace K

Problem Solving Skills Training in Adult Cancer Survivors: Bright IDEAS-AC

Principal Investigator: Noyes, Ekaterina

Understanding health behaviors and perceptions of cancer in non-English speaking populations

Principal Investigator: Glaser, Kathryn M

(UTX-TGR-205) A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 with or without Bendamustine and TGR-1202 alone in Patients with Previously Treated Non-Hodgkin¿s Lymphoma

Principal Investigator: Sundaram, Suchitra

A Phase 1b/2 Study of PCM-075 in Combination with either Low-Dose Cytarabine or Decitabine in Subjects with Acute Myeloid Leukemia (AML)

Principal Investigator: Wang, Eunice S

Phase 1 dose escalation, multi-tumor study to assess the safety, tolerability and antitumor activity of genetically engineered MAGE-A4c1032T in HLA-A2+ subjects with MAGE-A4 positive tumors (ADP-0044-001)

Principal Investigator: Odunsi, Adekunle O

(ARO-013) Phase III Randomized, Double-blind, Placebo-controlled Study Investigating the Efficacy of the Addition of Crenolanib to Salvage Chemotherapy Versus Salvage Chemotherapy Alone in Subjects = 75 Years of Age with Relapsed/Refractory FLT3...

Principal Investigator: Wang, Eunice S

General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial: Pragmatic Randomized Trial of Propofol vs Volatile Inhalational Anesthesia

Principal Investigator: Quinn, Timothy D

A Randomized, Open-Label Study to Assess the Pain, Toxicity and Quality of Life Effects of Adding Venlafaxine to the Pain Management Regimen for Patients Treated with Chemoradiation for Head and Neck Cancer

Principal Investigator: Singh, Anurag K

A Phase 1 Dose Escalation Trial of SKI-G-801 in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)

Principal Investigator: Wang, Eunice S

An Open-Label Phase 1/2 Study of JCARH125, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in Subjects with Relapsed or Refractory Multiple Myeloma

Principal Investigator: Lee, Kelvin

(ARO-021) Phase III Randomized Study of Crenolanib versus Midostaurin Administered Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed Subjects with FLT3 Mutated Acute Myeloid Leukemia

Principal Investigator: Wang, Eunice S

First-in-human, open-label, dose escalation trial with expansion cohorts to evaluate safety of Axl-specific antibody-drug conjugate (enapotamab vedotin, HuMax-AXL-ADC) in patients with solid tumors

Principal Investigator: Dy, Grace K

Clinical Proteomics Tumor Analysis Consortium (CPTAC) Phase III Research Protocol

Principal Investigator: Foster, Barbara A

A Phase 1, Multi-center, Open-label Study of IMGN632 Administered Intravenously in Patients with Relapsed/Refractory CD123-positive Acute Myeloid Leukemia and Other CD123-positive Hematologic Malignancies

Principal Investigator: Wang, Eunice S

Effects of package color and descriptors on tobacco product perceptions (COMET 2 1.2)

Principal Investigator: O'Connor, Richard J

A Pilot Study of Photoacoustic Imaging (PAI)

Principal Investigator: Singh, Anurag K

(NSABP B-51) A Randomized Phase III Clinical Trial Evauluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to...

Principal Investigator: Fung-Kee-Fung, Simon

(NRG-HN004) Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin

Principal Investigator: Singh, Anurag K

RE-AIMing Nurses for Sleep Screening, Brief Intervention and Referral to Treatment (Sleep-SBIRT)

Principal Investigator: Dean, Grace E

Isolation of CD34 stem cells using the Miltenyi Biotec CliniMACS CD34 Reagent System as a humanitarian use device

Principal Investigator: Chen, George L

AALL1631 International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Ph+ ALL Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy Backbones

Principal Investigator: Twist, Clare J

A PHASE 1 DOSE ESCALATION STUDY OF DS-3032B, AN ORAL MDM2 INHIBITOR, AS SINGLE AGENT AND IN COMBINATION WITH 5-AZACITIDINE IN SUBJECTS WITH ACUTE MYELOGENOUS LEUKEMIA (AML) OR HIGH-RISK MYELODYSPLASTIC SYNDROME (MDS)

Principal Investigator: Wang, Eunice S

(A221504) A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT STUDY OF AN ORAL, SELECTIVE PERIPHERAL OPIOID RECEPTOR ANTAGONIST IN ADVANCED NON-SMALL CELL LUNG CANCER (ADENOCARCINOMA)

Principal Investigator: Chen, Hongbin

Opioid Use in Post-operative Gynecologic Oncology Patients

Principal Investigator: Zsiros, Emese

A MULTICENTER, OPEN-LABEL, PHASE 1B/2 STUDY TO EVALUATE SAFETY AND EFFICACY OF AVELUMAB (MSB0010718C) IN COMBINATION WITH CHEMOTHERAPY WITH OR WITHOUT OTHER ANTI-CANCER IMMUNOTHERAPIES AS FIRST-LINE TREATMENT IN PATIENTS WITH ADVANCED MALIGNANCIES

Principal Investigator: George, Saby

(ADP-0000-001) A Screening Protocol to Determine Tumor Antigen Expression and HLA Sub-Type for Eligibility Determination for Clinical Trials Evaluating the Safety and Efficacy of Autologous T Cells Expressing Enhanced TCRs in Subjects with Solid or...

Principal Investigator: Odunsi, Adekunle O

(ACCRU-GI-1617) MOUNTAINEER: A Phase II, Open Label Study of Tucatinib Combined with Trastuzumab in Patients with HER2+ Metastatic Colorectal Cancer

Principal Investigator: Boland, Patrick M

(SGN22E-002) A phase 1b dose-escalation and dose-expansion study of enfortumab vedotin (ASG-22CE) in combination with pembrolizumab and/or chemotherapy for treatment of patients with locally advanced or metastatic urothelial cancer

Principal Investigator: George, Saby

(SWOG S1616) A Phase II Randomized Study of Nivolumab (NSC-748726) with Ipilimumab (NSC-732442) OR Ipilimumab Alone in Advanced Melanoma Patients Refractory to an Anti-PD-1 or Anti-PD-L1 Agent

Principal Investigator: Puzanov, Igor

A Phase 2, Randomized, Biomarker-driven, Clinical Study in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) with MCL-1 Dependence &#8805;40%

Principal Investigator: Wang, Eunice S

A Phase II Neoadjuvant Study of Palbociclib in Combination with Letrozole and Trastuzumab as Neoadjuvant Treatment of Stage II-III ER+ HER2+ Breast Cancer (PALTAN)

Principal Investigator: Levine, Ellis G

The GYN Molecular Information Registry

Principal Investigator: Odunsi, Adekunle O

(A031501) Phase III Randomized Adjuvant study of MK-3475 (pembrolizumab) in muScle invaSive and locally ADvanced urOthelial caRcinoma (AMBASSADOR) versus observation

Principal Investigator: Levine, Ellis G

(A021502) Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch

Principal Investigator: Boland, Patrick M

A Non-Randomized, Open-Label, Phase 2 Study of Trametinib in Patients with Unresectable or Metastatic Epithelioid Hemangioendothelioma

Principal Investigator: Grand'Maison, Anne C

(A041501) A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) with Newly Diagnosed Precursor B-Cell ALL

Principal Investigator: Wang, Eunice S

(ONO-7475-01) A Phase I open label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary clinical efficacy of ONO-7475 in patients with acute leukemias

Principal Investigator: Wang, Eunice S

(ALTE1631) A Randomized Web-Based Physical Activity Intervention Among Children and Adolescents with Acute Lymphoblastic Leukemia

Principal Investigator: Rokitka, Denise A

Phase 2, Multicenter Study to Assess the Efficacy and Safety of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Treatment of Patients with Metastatic Melanoma

Principal Investigator: Ernstoff, Marc S

(APEC1621SC) NCI-COG PEDIATRIC MATCH (MOLECULAR ANALYSIS FOR THERAPY CHOICE) SCREENING PROTOCOL

Principal Investigator: Twist, Clare J

Electronic Cigarette Use During Pregnancy

Principal Investigator: Goniewicz, Maciej L

ALTE 15N2 LEAHRN (Late Effects After High-Risk Neuroblastoma) Study

Principal Investigator: Rokitka, Denise A

Phase II Study of Targeting CD28 in Multiple Myeloma with Abatacept (CTLA4-Ig) to Overcome Resistance to Chemotherapy

Principal Investigator: Lee, Kelvin

(APEC1621) NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)

Principal Investigator: Twist, Clare J

ACNS 1422 A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients

Principal Investigator: Twist, Clare J

A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial Cancer

Principal Investigator: Chatta, Gurkamal S

Validation of a mobile imaging system for oral cancer screening in low resource settings in India

Principal Investigator: Singh, Anurag K

(BMT CTN Protocol 1507) Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease

Principal Investigator: Balderman, Sophia R

Phase 2A Study Evaluating a Chemokine-Modulatory Regimen in Patients with Colorectal Cancer Metastatic to the Liver

Principal Investigator: Boland, Patrick M

A Phase 1, Open-Label, Dose-Escalation and Cohort Expansion First-in-Human Study of the Safety, Tolerability, Activity and Pharmacokinetics of REGN3767 (anit-LAG-3 mAb) Administered Alone or in Combination with REGN2810 (anti-PD-1 mAb) in Patients with...

Principal Investigator: Dy, Grace K

(NRG-GY006) A Randomized phase III trial of radiation therapy and cisplatin alone or in combination with intravenous triapine in women with newly diagnosed bulky stage IB2, or stage II, IIIB, or IVA cancer of the uterine cervix or stage II-IVA vaginal...

Principal Investigator: Lele, Shashikant B

A Phase Ib/II Study of Propranolol with Fixed-dose Pembrolizumab in Patients with Unresectable Stage III and Stage IV Melanoma

Principal Investigator: Gandhi, Shipra

A Phase 2 Study of the Safety, Tolerability, and Efficacy of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis

Principal Investigator: Wang, Eunice S

ADVL1622 Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

Principal Investigator: Twist, Clare J

A Phase 1/2, Multicenter, Open-Label, Study of FT 2102 as a Single Agent and in Combination with Azacitidine or Cytarabine in Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome with an IDH1 Mutation

Principal Investigator: Wang, Eunice S

AGCT1531 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors

Principal Investigator: Twist, Clare J

RCT of Online Mindfulness-Based Stress Reduction for Metastatic Breast Cancer Patients

Principal Investigator: Hydeman, Jennifer A

The effect of extra-physiologic oxygen shock / stress (EPHOSS) on human hematopoietic stem cell viability and multi-potency

Principal Investigator: Chen, George L

PHASE 1/2 STUDY OF TAS-120 IN PATIENTS WITH ADVANCED SOLID TUMORS HARBORING FGF/FGFR ABERRATIONS

Principal Investigator: Iyer, Renuka V

A Phase 1 Study of DEC205mAb-NY ESO 1 Fusion Protein (CDX-1401) given with Adjuvant Poly-ICLC in Conjunction with 5-Aza-2'deoxycytidine (Decitabine) and Nivolumab in Patients with MDS or Low Blast Count AML

Principal Investigator: Griffiths, Elizabeth A

An Open-Label, Single-Arm, Phase 2 Study of AVB-620 in Women with Primary Nonrecurrent Breast Cancer Undergoing Surgery

Principal Investigator: Takabe, Kazuaki

CABL001A2301; A phase 3, multi-center, open-label, randomized study of oral ABL001 (asciminib) versus bosutinib in patients with Chronic Myelogenous Leukemia in chronic phase (CML-CP), previously treated with 2 or more tyrosine kinase inhibitors

Principal Investigator: Thompson, J E

A PHASE II TRIAL OF HAPLOIDENTICAL ALLOGENEIC STEM CELL TRANSPLANTATION UTILIZING MOBILIZED PERIPHERAL BLOOD STEM CELLS.

Principal Investigator: Balderman, Sophia R

Three Pilot Studies of Stereotactic Body Radiation Therapy (SBRT) and Surgery in Non-Small Cell Lung Cancer

Principal Investigator: Singh, Anurag K

A Multicenter Phase 2, Adaptive, Open-Label Trial of Intratumoral pIL-12 plus Electroporation in Combination with Pembrolizumab in Patients with Stage III/IV Melanoma who are Progressing on either Pembrolizumab or Nivolumab Treatment

Principal Investigator: Puzanov, Igor

CA-ALT-803-01-16 QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

Principal Investigator: Guru, Khurshid

Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial for Low Risk DCIS: A Phase III Prospective Randomization Trial

Principal Investigator: Levine, Ellis G

IRONMAN: International Registry for Men with Advanced Prostate Cancer

Principal Investigator: Chatta, Gurkamal S

A Phase 3 Randomized Study Comparing Nivolumab and Ipilimumab Combination vs Placebo in Participants with Localized Renal Cell Carcinoma Who Underwent Radical or Partial Nephrectomy and Who Are at High Risk of Relapse

Principal Investigator: George, Saby

IMCgp100-202, A Phase II Randomized, Open-label, Multi-center Study of the Safety and Efficacy of IMCgp100 Compared with Investigator's Choice in HLA-A*0201 Positive Patients with Previously Untreated Advanced Uveal Melanoma

Principal Investigator: Puzanov, Igor

A Pilot Study of Photoacoustic Imaging (PAI) in H&N Cancer Patients

Principal Investigator: Singh, Anurag K

(ASTX660-01) Phase 1-2 Study of the Safety, Pharmacokinetics, and Preliminary Activity of ASTX660 in Subjects with Advanced Solid Tumors and Lymphomas

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

Impact of Menthol Delivery Methods on Smoker Sensory Perceptions

Principal Investigator: O'Connor, Richard J

Race and geographic differences in diagnosis with metastatic Prostate cancer and early detection

Principal Investigator: Sumlin, Adam B

TISSUE AND DATA ACQUISITION ACTIVITY FOR THE STUDY OF GYNECOLOGIC DISEASE

Principal Investigator: Odunsi, Adekunle O

MammaPrint, BluePrint, and Full-genome Data Linked with Clinical Data to Evaluate New Gene Expression Profiles: An Adaptable Registry (FLEX Registry)

Principal Investigator: Levine, Ellis G

DFCI ALL Consortium 16-001: Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

Principal Investigator: Kelly, Kara M

A Phase 1/2 dose escalation study with expansion cohorts to investigate the safety, biologic and anti-tumor activity of ONCOS-102 in combination with durvalumab in subjects with advanced peritoneal malignancies

Principal Investigator: Odunsi, Adekunle O

AHOD1721, Risk-based, response-adapted, Phase II open-label trial of nivolumab + brentuximab vedotin(N + Bv) for children, adolescents, and young adults with relapsed/refractory (R/R) CD30 +classic Hodgkin lymphoma (cHL) after failure of first-line...

Principal Investigator: Kelly, Kara M

Life On The Go 2: Evaluating the Effect of Physical Activity of Patients with Recurrent Ovarian Cancer Using State of the Art Activity Tracking Device

Principal Investigator: Zsiros, Emese

SL-401 in Patients with Advanced, High Risk Myeloproliferative Neoplasms

Principal Investigator: Wang, Eunice S

(NCI 9930) A Phase I Trial of MEDI-570 in Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma (PTCL) Follicular Variant and Angioimmunoblastic T-Cell Lymphoma (AITL)

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

Implementing a Low Glycemic Diet in Children and Adolescents Undergoing Treatment for Acute Lymphoblastic Leukemia

Principal Investigator: Kelly, Kara M

A Pilot Study of Feasibility of Performing Intravital Microscopy in Patients with Ovarian, Primary Peritoneal or Fallopian Tube Cancer

Principal Investigator: Odunsi, Adekunle O

(S1609) DART: Dual Anti-CTLA-4 and Anti-PD-1 blockade in Rare Tumors

Principal Investigator: Puzanov, Igor

A Phase Ib/2 Trial of Fludarabine/Melphalan/Total Body Irradiation with Post Transplant Cyclophosphamide as Graft versus Host Disease Prophylaxis in Matched-Related and Matched-Unrelated Allogeneic Hematopoietic Cell Transplantation

Principal Investigator: Ho, Christine M

A Phase Ib/ II Study of Sorafenib and Pembrolizumab in Advanced Hepatocellular Cancer (HCC)

Principal Investigator: Iyer, Renuka V

A Phase 3 Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer

Principal Investigator: Mohler, James L

Exercise to Improve Health and Quality-of-life in Breast Cancer Survivors: A Feasibility Pilot Trial

Principal Investigator: O'Connor, Tracey L

(RTOG 1119) Phase II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery in Combination with Concurrent Lapatinib in Patients with Brain Metastasis From HER2-Positive Breast Cancer - A Collaborative Study of NRG Oncology and KROG

Principal Investigator: Prasad, Dheerendra

Direct oral anticoagulants (DOACs) versus LMWH +/- warfarin for VTE in cancer: A randomized effectiveness trial (CANVAS trial)

Principal Investigator: Levine, Ellis G

BMT CTN 1502 Optimizing Haploidentical Aplastic Anemia Transplantation (CHAMP)

Principal Investigator: Bambach, Barbara J

A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer Associated with Homologous Recombination Deficiency

Principal Investigator: Chatta, Gurkamal S

A Phase 2, Fast Real-time Assessment of Combination Therapies in Immuno-ONcology Study in Participants with Advanced Renal Cell Carcinoma (FRACTION-RCC)

Principal Investigator: George, Saby

A Phase 1/1b, Open-Label, Multicenter, Repeat-Dose, Dose-Selection Study of CPI-444 as Single Agent and in Combination with Atezolizumab in Patients with Selected Incurable Cancers

Principal Investigator: George, Saby

A Multicenter Pivotal Phase 3 study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects with Active, Relapsed, or Refractory Acute Myeloid Leukemia

Principal Investigator: Chen, George L

MATCH Treatment Subprotocol L: Phase II Study of MLN0128 (TAK-228) in Patients with Tumors with mTOR Mutations

Principal Investigator: Levine, Ellis G

INCB 18424-269 (COG AALL1521) A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway Mutant Acute Lymphoblastic Leukemia

Principal Investigator: Twist, Clare J

A Phase 2, Multicenter Study to Evaluate the Efficacy and Safety Using Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients with Recurrent, Metastatic or Persistent Cervical Carcinoma

Principal Investigator: Zsiros, Emese

A Phase 3 Multicenter, Open-label, Randomized Study of ASP2215 (Gilteritinib), Combination of ASP2215 Plus Azacitidine and Azacitidine Alone in the Treatment of Newly Diagnosed Acute Myeloid Leukemia with FLT3 Mutation in Patients Not Eligible for...

Principal Investigator: Wang, Eunice S

MATCH Treatment Subprotocol Z1E: LOXO-101 in Patients with Tumors with NTRK Fusions

Principal Investigator: Levine, Ellis G

MATCH Treatment Subprotocol J: Trastuzumab and Pertuzumab (HP) in Patients with Non-Breast, Non-Gastric/GEJ,and Non-Colorectal Cancers with HER2 Amplification

Principal Investigator: Levine, Ellis G

(S1512) A Phase II and Pilot Trial of PD-1 Blockade with MK-3475 (Pembrolizumab) in Patients with Resectable or Unresectable Desmoplastic Melanoma (DM)

Principal Investigator: Ernstoff, Marc S

(S1418/BR006) A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 [Pembrolizumab] as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with > 1 cm Residual Invasive Cancer or Positive Lymph Nodes (>pN1mic) After...

Principal Investigator: Levine, Ellis G

Study 16-214-02 (Combination): A PHASE 1/2, OPEN-LABEL, MULTICENTER STUDY OF THE COMBINATION OF NKTR-214 AND NIVOLUMAB OR THE COMBINATION OF NKTR-214, NIVOLUMAB, AND OTHER ANTI-CANCER THERAPIES IN PATIENTS WITH SELECT LOCALLY ADVANCED OR METASTATIC...

Principal Investigator: Puzanov, Igor

A phase 1/2 Study of in situ vaccination with tremelimumab and IV durvalumab (MEDI4736) plus the Toll-like receptor agonist PolyICLC in Subjects with Advanced, Measurable, Biopsy-accessible Cancers

Principal Investigator: Puzanov, Igor

(A011502): A Randomized Phase III Double Blinded Placebo Controlled Trial of Asprin as Adjuvant Therapy for HER2 Negative Breast Cancer: The ABC Trial

Principal Investigator: Levine, Ellis G

Moral Distress in Nurses providing direct patient care on inpatient oncology units and outpatient clinics

Principal Investigator: Dean, Grace E

(COG AAML1531) Risk-Stratified Therapy for Acute Myeloid Leukemia in Down Syndrome

Principal Investigator: Twist, Clare J

A multinational, open-label, dose escalation Phase I Study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumor types

Principal Investigator: Odunsi, Adekunle O

NRG-GYN 005 A Randomized Phase II/III study of the combination of Cediranib and Olaparib compared to Cediranib or Olaparib alone, or Standard of care chemotherapy in women with recurrent platinum-resistant or -refractory ovarian, fallopian tube, or...

Principal Investigator: Lele, Shashikant B

A Randomized Multicenter Phase II Study Using (2-1[Heyloxyethyl]-2-Devinylpyropheophorbide-a) (HPPH) with PDT versus Standard of Care Surgery for Patients with T1/T2 N0 Squamous Cell Carcinoma of the Oral Cavity

Principal Investigator: Arshad, Hassan

A011401; Randomized Phase III Trial Evaluating The Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early Breast Cancer

Principal Investigator: O'Connor, Tracey L

(CITN-12) Phase I Study of MK-3475 (Pembrolizumab) in Patients with Human Immunodeficiency Virus (HIV) and Relapsed/Refractory or Disseminated Malignant Neoplasm

Principal Investigator: Ernstoff, Marc S

(COG ARST1431) A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating with Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864, IND# 122782) in Patients with Intermediate Risk...

Principal Investigator: Twist, Clare J

A Phase I, Open Label Study Evaluating the Safety and Efficacy of Adoptive transfer of Autologous NY-ESO-1 CD8-TCR Engineered T Cells and NY-ESO-1 CD4-TCR Engineered Hematopoietic Stem Cells (HSC) after a Myeloablative Conditioning Regimen, with...

Principal Investigator: Odunsi, Adekunle O

A Phase I Open Label Clinical Trial Evaluating the Safety and Efficacy of Adoptive Transfer of NY-ESO-1 TCR Engineered Autologous T Cells in Combination with Decitabine in Patients with Recurrent or Treatment Refractory Ovarian Cancer

Principal Investigator: Odunsi, Adekunle O

MATCH Treatment Subprotocol C2: Crizotinib in Patients with Tumors with MET Exon 14 Deletion

Principal Investigator: Levine, Ellis G

A Phase I/II Basket Trial of the EGF Vaccine CIMAvax in Combination with the Anti-PD1 Therapy in Patients with Advanced NSCLC or Squamous Head and Neck Cancer

Principal Investigator: Dy, Grace K

Double-arm, Randomized Study of Botulinum Toxin Injection as a Pyloric Drainage Procedure for Minimally Invasive Esophagectomy (Phase II)

Principal Investigator: Kukar, Moshim

A Phase I/II Evaluation of Olaparib in combination with Durvalumab and Tremelimumab in the Treatment of Recurrent Platinum Sensitive or Resistant or Refractory Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer in Patients who Carry a...

Principal Investigator: Odunsi, Adekunle O

A Phase 1 Study of ALKS 4230 Administered Intravenously as Monotherapy and in Combinationwith Pembrolizumab in Subjects with Advanced Solid Tumors

Principal Investigator: Ernstoff, Marc S

(EA5142) Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers

Principal Investigator: Dy, Grace K

(COG ALTE1621) Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Heart Failure (PREVENT-HF): A Phase 2b Randomized Placebo-Controlled (Carvedilol) Trial

Principal Investigator: Rokitka, Denise A

A Phase 1/2, Open-Label, Dose-Escalation/Dose-Expansion, Safety and Tolerability Study of INCB059872 in Subjects With Advanced Malignancies

Principal Investigator: Wang, Eunice S

(EAY 131-V MATCH): Phase II Study of Sunitinib in Patients with Tumors with cKIT Mutations (Excluding GIST, Renal Cell Carcinoma or Pancreatic Neuroendocrine Tumor)

Principal Investigator: Levine, Ellis G

(EAY 131-T MATCH): GDC-0449 (vismodegib) in Patients with Tumors (except basal cell skin carcinoma) with Smoothened (SMO) or Patched 1 (PTCH1) Mutations

Principal Investigator: Levine, Ellis G

(EAY 131-E MATCH): AZD9291 in Patients with Tumors Having EGFR T790M Mutations (Except Non-Small Cell Lung Cancer) or Rare Activating Mutations of EGFR

Principal Investigator: Levine, Ellis G

(EAY 131-A MATCH): Phase II Trial of Afatinib in Patients with Solid Tumors (Other Than Small Cell and Non-Small Cell Lung Cancer) or Lymphomas, That Have Activating Mutations of EGFR and Have Progressed After Standard Treatment

Principal Investigator: Levine, Ellis G

(EAY 131 Master Protocol) Molecular Analysis for Therapy Choice (MATCH)

Principal Investigator: Levine, Ellis G

A Phase I Study of Safety, Tolerability and Immunological Effects of SVN53-67/M57-KLH in Patients with Multiple Myeloma Receiving Lenalidomide Maintenance Therapy

Principal Investigator: Lee, Kelvin

(EA1131) A Randomized Phase III Post-Operative Trial of Platinum Based Chemotherapy Vs. Capecitabine in Patients with Residual Triple-Negative Basal-Like Breast Cancer following Neoadjuvant Chemotherapy

Principal Investigator: Levine, Ellis G

(COG APEC14B1) The Project: Everychild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

Principal Investigator: Twist, Clare J

A Phase Ib/II Study of Cetuximab and Pembrolizumab in Metastatic Colorectal Cancer

Principal Investigator: Boland, Patrick M

(12-100) Phase I/II Trial of Pre-Operative Image Guided Intensity Modulated Proton Radiation Therapy (IMPT) or Photon (IMRT) with Simultaneously Integrated Boost to the High Risk Margin for Retroperitoneal Sarcomas

Principal Investigator: Chowdhry, Varun K

(A031102) A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) with High-Dose Chemotherapy Using Mobilizing Pacilitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide ...

Principal Investigator: Levine, Ellis G

A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer

Principal Investigator: Levine, Ellis G

A Dose Regimen-Finding Study to Evaluate the Safety, Tolerability, Maximum Tolerated Dose, Pharmacokinetics, and Activity of Oraxol in Subjects with Advanced Malignancies

Principal Investigator: Fountzilas, Christos

(ACCL1333/CV185-155) A Phase III Randomized, Open Label, Multi-center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly...

Principal Investigator: Bambach, Barbara J

(COG AALL1331) Risk-Stratified Randomized Phase III Testing of Blinatumomab (IND# 117467, NSC# 765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)

Principal Investigator: Twist, Clare J

A Phase II, Multicenter, Study of Oral cMET Inhibitor INC280 in Adult Patients with EGFR Wild-Type (wt), Advanced Non-Small Cell Lung Cancer (NSCLC)

Principal Investigator: Chen, Hongbin

(COG ANBL1232) Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma

Principal Investigator: Twist, Clare J

(E4512 )A randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

Principal Investigator: Chen, Hongbin

(A081105) Randomized Study of Erlotinib or Observation in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC)

Principal Investigator: Dy, Grace K

(A151216) Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

Principal Investigator: Dy, Grace K

A Phase I/IIa Study of TGFß Blockade in TCR-Engineered T-Cell Cancer Immunotherapy in Patients with Advanced Malignancies

Principal Investigator: Odunsi, Adekunle O

(E1910) A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia in Adults

Principal Investigator: Wang, Eunice S

A Dose-Regimen Finding Study to Evaluate Safety, Tolerability, Pharmacokinetics and Activity of Oratecan in Subjects with Advanced Malignancies

Principal Investigator: Boland, Patrick M

Detection of Early Lung Cancer Among Military Personnel Study 2 (DECAMP-2): Screening of Patients at High Risk for Developing Lung Cancer with a Civilian Expansion

Principal Investigator: Reid, Mary E

A Phase I/IIb Study of DEC205mAb-NY-ESO-1 Fusion Protein (CDX-1401) Given with Adjuvant Poly-ICLC in Combination with INCB024360 for Patients in Remission with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma Whose Tumors Express NY...

Principal Investigator: Odunsi, Adekunle O

(COG ALTE11C2) Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy

Principal Investigator: Rokitka, Denise A

Phase I/Ib Study of Carfilzomib plus Rituximab plus Ifosfamide plus Carboplatin plus Etoposide (C-R-ICE) in Patients with Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

NY-ESO-1 Expression in Patients with Solid Tumors

Principal Investigator: Odunsi, Adekunle O

A Phase I/ II Trial of Pazopanib Alternating with Bevacizumab in Treatment-Naive Metastatic Clear Cell Renal Cell Carcinoma Patients

Principal Investigator: George, Saby

(CIBMTR 10-CBA) A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications

Principal Investigator: McCarthy, Philip L

Examining Quality of Life Among Long-Term Survivors of Childhood Cancer

Principal Investigator: Rokitka, Denise A

Filgrastim-Mobilized Peripheral Blood Stem Cells for Allogeneic Transplantation with Unrelated Donors

Principal Investigator: McCarthy, Philip L

(COG ALTE05N1/ DB 2518) Umbrella Long-Term Follow-Up Protocol

Principal Investigator: Rokitka, Denise A

Evaluation of Smoker Reactions to Novel Tobacco Products

Principal Investigator: Bansal Travers, Maansi

Lung Bronchoscopy Research Samples & Database

Principal Investigator: Hennon, Mark W

(ALTE03N1/ CHOB 2519) Key Adverse Events Following Childhood Cancer

Principal Investigator: Rokitka, Denise A

Novel Risk Factors and Potential Early Detection Markers for Ovarian Cancer

Principal Investigator: Moysich, Kirsten B

Collection of Blood from Healthy Donors and Patients with Non-Hodgkin's Lymphoma and Leukemia to Study the Immunological Activity of Peripheral Blood Mononuclear Cells (PBMC) and Human Serum

Principal Investigator: Hernandez-Ilizaliturri, Francisco J

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