Cancers Treated:
Research Interests:
Cell biology Mitochondrial biology Renal cell carcinoma Proteomics Metabolomics BiochemistryAbout Bradley Webster
Biography:
I was appointed to the faculty at Roswell Park Comprehensive Cancer Center in June 2023 as a member of both the Department of Urology and Department of Cell Stress Biology. Prior to this, I completed my undergraduate studies in biomedical engineering at Cornell University in Ithaca, NY (2004). I then completed my MD/PhD training at the University of New Mexico in 2015. As part of my PhD training, my dissertation research was performed at the National Institutes of Health (NIH) in Bethesda, MD, where I studied metabolism and mitochondrial biology. I then completed my internship in General Surgery (2016) and residency in Urology (2020) at the University of New Mexico in Albuquerque, NM. Most recently in 2023 and prior to joining Roswell Park, I finished my clinical and research fellowship in Urologic Oncology at the National Cancer Institute in Bethesda, MD.
Positions
- Assistant Professor of Urologic Oncology
- Department of Urology
- Assistant Professor of Oncology
- Department of Cell Stress Biology
Background
Education and Training:
- 2008-2013 - PhD - National Institutes of Health, Bethesda, MD and University of New Mexico, Albuquerque, NM
- 2006-2015- MD - University of New Mexico, Albuquerque, NM
Residency:
- 2020 - Urology - University of New Mexico, Albuquerque, NM
Fellowship:
- 2020-2023 - Clinical and research fellowship, National Cancer Institute, Bethesda, MD
Professional Memberships:
- Society of Urologic Oncology
- American Urological Association
Research
Research Overview:
1) Scott I,. Webster B.R., Li JH, Sack M.N. Identification of a molecular component of the mitochondrial acetyl transferase program: a novel role for GCN5L1. Biochemical J. 05/01/2012; 443 (3):655-61.
2) Webster B.R., Scott I, Han K, Li JH, Lu Z, Stevens MV, Malide D, Chen Y, Samsel L, Connelly PS, Daniels MP, McCoy JP Jr, Combs CA, Gucek M, Sack M.N. Restricted mitochondrial protein acetylation initiates mitochondrial autophagy. J Cell Sci. 07/01/2013; 1 (126):4843-9.
3) Scott I, Webster B.R., Chan CK, Okonkwo JU, Han K, Sack M.N. GCN5-like Protein 1 (GCN5L1) Controls Mitochondrial Content through Coordinated Regulation of Mitochondrial Biogenesis and Mitophagy. J Biol Chem. 06/01/2014. 289 (5):2864-72.
4) Webster, B.R., Gopal, N., Ball, M. Tumorigenesis Mechanisms Found in Hereditary Renal Cell Carcinoma: A Review. Genes, 11/15/22; 13 (11): 2122.
5) Webster, B.R. Daneshvar, M. Rompre-Brodeur, Al. Ricketts, CJ. Linehan WM., and Srinivasan, R. . GCN5L1 Regulates Mitochondrial Protein Acetylation, Lipid Accumulation and Cell Growth in VHL-deficient Clear Cell Renal Cell Carcinoma. In preparation 2023.
