Oncologic surgical pathology with emphasis in genito-urologic tumorsThoracic pathologyHead/neck pathology
Histomorphological diagnosis, Classification and staging of urologic and male genital tumors, lung and mediastinal tumors, head & neck tumorsClinicopathologic correlation and translational research on above tumors
Roswell Park Comprehensive Cancer Center
Associate Professor of Oncology
Department of Pathology & Laboratory Medicine
Education and Training:
PhD - Wright State University Biomedical Science Ph.D. Program, Dayton, OH
MD - Nanjing Medical University Faculty of Medicine, Nanjing, China
Department of Pathology, SUNY at Buffalo, Buffalo, NY
Department of Medicine, Section of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Visiting Fellow, Section of Genitourinary Pathology, Indiana University School of Medicine, Indianapolis, IN
Fellow, Ontological Surgical Pathology, Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY
Post-doctoral Fellow, Howard Hughes Medical Institute Department of Microbiology & Immunology Vanderbilt University School of Medicine, Nashville, TN
Anatomic Pathology, American Board of Pathology
Clinical Pathology, American Board of Pathology
United States and Canadian Academy of Pathology
American Society of Clinical Pathologists
College of American Pathologists
Association of Molecular Pathology
Shen, H, Blijlevens, M, Yang, N, Frangou, C, Wilson, KE, Xu, B, Zhang, Y, Zhang, L, Morrison, CD, Shepherd, L, Hu, Q, Zhu, Q, Wang, J, Liu, S and Zhang, J. Sox-4 expression confers bladder cancer stem cell properties and predicts for poor patient outcome. 2015. Int. J. Biol. Sci. In Press
Sule, N, Xu, B, Zein, D, Szigeti, K, Kane, J, Cheney, RT. Radiation induced chondrosarcoma of the bladder, case report and review of literature. 2015. Anticancer. 35(5):2857-60.
Cheng, J, Ondracek, RP, Mehedint, D, Kasza, K, Xu, B, Gill, S, Azabdaftari G,Yao, S, Morrison, C, Mohler, J, Marshall, J,. Association of Fatty Acid Synthase Polymorphisms and Expression with Outcomes after Radical Prostatectomy. 2015. Prostate Cancer Prostatic Dis. 18(2):182-9.
Pokuri, VK, Xu, B, Neppalli, V, Czyzyk, J, Berenji, F, Holstein, SA, McCarthy, PL. Synchronous presentation of monoclonal gammopathy and Fabry nephropathy; diagnostic renal biopsy obviates initiation of myeloma therapy. 2015. Ann. Hematol. 94(6):1067-68.
Li, YW, Shen H, Yang, N, Guo, J, Xu, B, Bshara, W, Shepherd, L, Zhu, Q, Wang, J, Hu, Q, Liu, S, Morrison, CM, Sun, P and Zhang, J. Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis. 2015. Cell Cycle. 14(1):146-156.
Zhong, H, George, S, Kauffman, E, Guru, K, Azabdaftari, G and Xu, B. Clinicopathologic characterization of intradiverticular carcinoma of urinary bladder - a study of 22 cases from a single cancer center. 2014. Diagn Pathol. 9:222-228.
Vacchio, M, Attwood, K, Mechedint, D, Murekeyioni, Azabdaftari, G, Xu, B, Mohler, J and Kauffman E. Does prospectively assigned tertiary pattern 4 affect prognosis of Gleason grade 3+3=6 prostatectomy patients? 2014. J. Urol. 191(4):926-927
Nakanishi, Y, Xu, B and LeVea, C. Oral Floor and Gingival Metastasis of Cholangiocarcinoma: A Case Report and Review of the Literature. 2014. Case Reports in Pathology. Volume 2014, Article ID 712912, 3 pages. http://dx.doi.org/10.1155/2014/712912.
Zhong, H, Xu, B and Popiolek, DA. Growth Patterns of Placental and Paraovarian Adrenocortical Heterotopias Are Different. Case Reports in Pathology. Volume 2013, Article ID 205692, 6 pages. http://dx.doi.org/10.1155/2013/205692
Pokuri, V, Sule, S, Soofi, Y, Xu, B, Guru K and George, S. A Case of Unusual Mast Cell Response with Interstitial Cystitis-Like Symptoms to Neoadjuvant Chemotherapy for Muscle-Invasive Transitional Cell Carcinoma of the Bladder. J Natl Compr Canc Netw 2013;11:1459-1463.
Gao, C, D’Angelis, CD, Qiu, J and Xu, B. Hyalin globules in epithelial neoplasm of kidney (Review article). 2013. North Am J Med & Sci. 6 (1):41-43.
Liu, YG, Cheney, RT, Omilian, A, Morrison C and Xu, B. Expression of PAX2 and renal cell carcinoma antigen in mucoepidermoid carcinoma. 2012. North Am J Med & Sci. 5 (4):203-207.
Sinnott, M, Chen, F, Kanehira, K, Sule, N and Xu, B. Clear cell papillary renal cell carcinoma – A new emerging entity (Review article). 2012. North Am J Med & Sci. 5 (4):224-227.
Liu, YG, Xu, B and Chen F. Recent advances in renal cell carcinoma associated with Xp11.2 translocations/TFE gene fusions (Review article). 2012. North Am J Med & Sci. 5 (1):43-47.
Hsi, LC, Kundu, S, Palomo J., Xu, B, Ficco, R, Vogelbaum, MA and Cathcart, MK. Silencing IL-13Ra2 promotes glioblastoma cell death via endogenous signaling. 2011. Mol Cancer Ther. 10(7):1149-60.
Xu, B, Tan, DF, Thong, T and Khoury, T. Expression of thyroid transcription factor-1 in Colorectal Carcinoma. 2010. Appl Immunohistochem Mol Morphol. 18(3):244-249.
Xu, B, Lin, L, and Chen, F. Desmoplastic Trichoepithelioma with Milia-like Structure. 2009. North Am J Med & Sci. 2 (1):22-23.
Xu, B, Balos, L, Goodloe, S., Krabill, K, Chmiel, R and Chen, F. Immunohistochemical studies of cell cycle-associated proteins in mandible central giant cell tumor. 2009. North Am J Med & Sci. 2 (2):10-12.
Bhattacharjee, A, Xu, B, Frank, DA, Feldman, GM and Cathcart, MK. Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3. 2006. J Immunol. 177:3771-81.
Skacel, M., Siva, A., Xu, B and Tubbs, RR. From array to array: Confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays. 2006. J Mol Histol. 38 (2):135-140.
Xu, B, Tubbs, RR and Kottke-Marchant, K. Molecular genetic testing of polymorphisms associated with venous thrombosis: A review of molecular technologies (Review article). 2005. Diagn Mol Pathol. 14 (4):193-202.
Zhao, X, Xu, B, Bhattacharjee, A, Horton, HM, Wientjes, FB, Cathcart, MK. Protein kinase C-delta regulates p67phox phosphorylation in human monocytes. 2005. J Leukoc Biol. 77:414-420.
Lin, L, Hicks, D, Xu, B, Sigel, JE, Bergfeld, WF, Montgomery, E, Fisher, C, Hartke, M, Tubbs, RR, Goldblum. JR. Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma. 2004. Modern Pathol. 18:705-709.
Xu, B, Bhattacharjee, A, Roy, B, Feldman, GM, Cathcart, MK, Role of protein kinase C isoforms in the regulation of IL-13-induced 15-lipoxygenase gene. 2004. J Bio Chem. 279 (16):15954-15960.
Bey, EA, Xu, B, Horton, CM, Bhattacharjee, A, Zhao, XX, Cathcart, MK. Protein kinase C-delta isoform mediates phosphorylation and membrane translocation of p47phox of NADPH oxidase in human monocytes. 2004. J Immunol. 173:5730-5738.
Das, M., Xu, B., Lin, L, Chakrabarti, S, Shivaswamy, V, Rote, NS. Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. 2004. Placenta. 25(5):396-407.
Agrawai, S, Podrez, E, Xu, B, Cathcart, M, Stark, GR and Chisoim, GM. Inhibition of stat1 activity inhibits foam cell formation in macrophages. 2004. Cardiovasc Pothol. 13(3):93-94.
Xu, B, Bhattacharjee, A, Roy B, Xu, HM, Anthony D, Frank, DA, Feldman, GM and Cathcart, MK. Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated Serine 727 phosphorylation of Stat1 and Stat3. 2003. Mol Cell Biol. 23:3918-3928.
Zhang, YM, Xu, B, Rote, NS, Peterson, L, and Amesse, L. Expression and function of HOX genes in human trophoblastic cells. 2002. Am J Obstet Gynecol. 187:24-32.
Roy, B, Bhattacharjee, A, Xu, B, Ford, D, Maizel, AL and Cathcart, MK. IL-13 signal transduction in human monocytes: Phosphorylation of receptor components, association with Jaks and phosphorylation of Stats. 2002. J Leukoc Biol. 72:580-589.
Lin, L, Xu, B, and Rote, NS. The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in human placental trophoblast model, BeWo. 2000. Placenta. 21:73-78.
Zhang YM, Xu, B, Peterson, L, Rote, NS and Amesse, L. Regulation of HOX A11 in trophoblastic cells. 2000. Fertility and Sterility. 74(3). DOI: 10.1016/S0015-0282(00)01294-2
Xu, B, Lin, L. and Rote, NS. Identification of a novel stress-induced protein involved in human choriocarcinoma BeWo cell differentiation by differential display analysis. 1999. Biol Reprod. 61:681-686.
Lin, L, Xu, B, and Rote, NS. Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast. 1999. Placenta. 20: 109-118.
Rote, N.S, Lin, L and Xu, B. The expression of ERV 3 mRNA in a choriocarcinoma model of trophoblastic differentiation. In: Carter, A. and H. Thiede (ed.), New Directions in Placental Research. University of Rochester Press, Rochester, NY, 1998. Trophoblast Research. 12: 315-326.
Wang, L, Xu, B, White, RE and Lu, L. Growth factor-mediated K+ channel activity associated with human myeloblastic ML-1 cell proliferation. 1997. Am J Physiol. 273: C1657-1665
Xu, B, Wilson, B, Lu, L. Induction of human myeloblastic ML-1 cell G1 arrest by suppression of K+ channel activity. 1996. Am J Physiol. 271: C2037-C2044.
Xu, B, Lu, L. Protein kinase A-regulated Cl- channel in ML-1 human hematopoietic myeloblasts. 1994. J Membrane Biol. 142: 65-75.