Bo Xu Bo Xu, MD, PhD

Bo Xu

MD, PhD
Anatomic Pathology

Specializing In:

Oncologic surgical pathology with emphasis in genito-urologic tumors Thoracic pathology Head/neck pathology

Special Interests:

Histomorphological diagnosis, Classification and staging of urologic and male genital tumors, lung and mediastinal tumors, head & neck tumors Clinicopathologic correlation and translational research on above tumors

About Bo Xu

Positions

Roswell Park Comprehensive Cancer Center
  • Staff Physician
  • Associate Professor of Oncology
  • Department of Pathology & Laboratory Medicine

Background

Education and Training:

  • PhD - Wright State University Biomedical Science Ph.D. Program, Dayton, OH
  • MD - Nanjing Medical University Faculty of Medicine, Nanjing, China

Residency:

  • Department of Pathology, SUNY at Buffalo, Buffalo, NY
  • Department of Medicine, Section of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Fellowship:

  • Visiting Fellow - Section of Genitourinary Pathology, Indiana University School of Medicine, Indianapolis, IN
  • Fellow - Ontological Surgical Pathology, Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY
  • Post-doctoral Fellow - Howard Hughes Medical Institute Department of Microbiology & Immunology Vanderbilt University School of Medicine, Nashville, TN

Board Certification:

  • Anatomic Pathology, American Board of Pathology
  • Clinical Pathology, American Board of Pathology

Professional Memberships:

  • United States and Canadian Academy of Pathology
  • American Society of Clinical Pathologists
  • College of American Pathologists
  • Association of Molecular Pathology

Publications

Full Publications list on PubMed
  • Shen H, Blijlevens M, Yang N, Frangou C, Wilson KE, Xu B, Zhang Y, Zhang L, Morrison CD, Shepherd L, Hu Q, Zhu Q, Wang J, Liu S, Zhang J. Sox4 Expression Confers Bladder Cancer Stem Cell Properties and Predicts for Poor Patient Outcome. Int J Biol Sci. 2015 Nov 1;11(12):1363-75. doi: 10.7150/ijbs.13240. PMID: 26681916; PMCID: PMC4671994.
  • Sule N, Xu BO, El Zein D, Szigeti K, George S, Kane JM, Cheney R. Radiation-induced Chondrosarcoma of the Bladder. Case Report and Review of Literature. Anticancer Res. 2015 May;35(5):2857-60. PMID: 25964567.
  • Cheng J, Ondracek RP, Mehedint DC, Kasza KA, Xu B, Gill S, Azabdaftari G, Yao S, Morrison CD, Mohler JL, Marshall JR. Association of fatty-acid synthase polymorphisms and expression with outcomes after radical prostatectomy. Prostate Cancer Prostatic Dis. 2015 Jun;18(2):182-9. doi: 10.1038/pcan.2015.11. Epub 2015 Apr 14. PMID: 25868764; PMCID: PMC4750391.
  • Pokuri VK, Xu B, Neppalli V, Czyzyk J, Berenji F, Holstein SA, McCarthy PL. Synchronous presentation of monoclonal gammopathy and Fabry nephropathy; diagnostic renal biopsy obviates initiation of myeloma therapy. Ann Hematol. 2015 Jun;94(6):1067-8. doi: 10.1007/s00277-015-2307-1. doi: 10.1007/s00277-015-2307-1. Epub 2015 Feb 10. PMID: 25666077.
  • Li YW, Shen H, Frangou C, Yang N, Guo J, Xu B, Bshara W, Shepherd L, Zhu Q, Wang J, Hu Q, Liu S, Morrison CD, Sun P, Zhang J. Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis. Cell Cycle. 2015;14(1):146-56. doi: 10.4161/15384101.2014.967106. PMID: 25602524; PMCID: PMC4352971.
  • Zhong H, George S, Kauffman E, Guru K, Azabdaftari G, Xu B. Clinicopathologic characterization of intradiverticular carcinoma of urinary bladder - a study of 22 cases from a single cancer center. Diagn Pathol. 2014 Nov 26;9:222. doi: 10.1186/s13000-014-0222-8. PMID: 25425482; PMCID: PMC4254201.
  • Vacchio M, Attwood K, Mechedint D, Murekeyioni C, Azabdaftari G, Xu B, Mohler J, Kauffman E. Does prospectively assigned tertiary pattern 4 affect prognosis of Gleason grade 3+3=6 prostatectomy patients? J Urol. 2014 Apr 1;191(4):926-927. doi: 10.1016/j.juro.2014.02.2499
  • Nakanishi Y, Xu B, LeVea C. Oral floor and gingival metastasis of cholangiocarcinoma: a case report and review of the literature. Case Rep Pathol. 2014;2014:712912. doi: 10.1155/2014/712912. Epub 2014 May 7. PMID: 24891967; PMCID: PMC4033480.
  • Zhong H, Xu B, Popiolek DA. Growth patterns of placental and paraovarian adrenocortical heterotopias are different. Case Rep Pathol. 2013;2013:205692. doi: 10.1155/2013/205692. Epub 2013 Dec 7. PMID: 24383032; PMCID: PMC3870631.
  • Pokuri V, Sule N, Soofi Y, Xu B, Guru K, George S. A case of unusual mast cell response with interstitial cystitis-like symptoms to neoadjuvant chemotherapy for muscle-invasive transitional cell carcinoma of the bladder. J Natl Compr Canc Netw. 2013 Dec 1;11(12):1459-63. doi: 10.6004/jnccn.2013.0172. PMID: 24335680.
  • Gao C, D’Angelis CD, Qiu J, Xu B. Hyaline globules in epithelial neoplasm of kidney. North Am J Med Sci. 2013; 6(1):41-43.
  • Liu YG, Cheney RT, Omilian A, Morrison C, Xu B. Expression of PAX2 and renal cell carcinoma antigen in mucoepidermoid carcinoma. North Am J Med Sci. 2012; 5(4):203-207.
  • Sinnott M, Chen F, Kanehira K, Sule N, Xu B. Clear cell papillary renal cell carcinoma – A new emerging entity. North Am J Med Sci. 2012; 5(4):224-227.
  • Liu YG, Xu B, Chen F. Recent advances in renal cell carcinoma associated with Xp11.2 translocations/TFE gene fusions. North Am J Med Sci. 2012; 5(1):43-47.
  • Hsi LC, Kundu S, Palomo J, Xu B, Ficco R, Vogelbaum MA, Cathcart MK. Silencing IL-13Rα2 promotes glioblastoma cell death via endogenous signaling. Mol Cancer Ther. 2011 Jul;10(7):1149-60. doi: 10.1158/1535-7163.MCT-10-1064. Epub 2011 May 19. PMID: 21596889; PMCID: PMC3132296.
  • Xu B, Thong N, Tan D, Khoury T. Expression of thyroid transcription factor-1 in colorectal carcinoma. Appl Immunohistochem Mol Morphol. 2010 May;18(3):244-9. doi: 10.1097/PAI.0b013e3181c29407. PMID: 20042854.
  • Xu B, Lin L, Chen F. Desmoplastic Trichoepithelioma with Milia-like Structure. North Am J Med Sci. 2009; 2(1):22-23.
  • Xu B, Balos L, Goodloe S, Krabill K, Chmiel R, Chen F. Immunohistochemical studies of cell cycle-associated proteins in mandible central giant cell tumor. North Am J Med Sci. 2009; 2(2):10-12.
  • Bhattacharjee A, Xu B, Frank DA, Feldman GM, Cathcart MK. Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3. J Immunol. 2006 Sep 15;177(6):3771-81. doi: 10.4049/jimmunol.177.6.3771. PMID: 16951338.
  • Skacel M, Siva A, Xu B, Tubbs RR. From array to array: Confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays. J Mol Histol. 2007 May;38(2):135-40. doi: 10.1007/s10735-006-9051-8. Epub 2006 Oct 17. PMID: 17043918.
  • Xu B, Tubbs RR, Kottke-Marchant K. Molecular genetic testing of polymorphisms associated with venous thrombosis: A review of molecular technologies. Diagn Mol Pathol. 2005 Dec;14(4):193-202. doi: 10.1097/01.pas.0000177796.73583.ml. PMID: 16319689.
  • Zhao X, Xu B, Bhattacharjee A, Oldfield CM, Wientjes FB, Feldman GM, Cathcart MK. Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes. J Leukoc Biol. 2005 Mar;77(3):414-20. doi: 10.1189/jlb.0504284. Epub 2004 Dec 9. PMID: 15591124.
  • Lin L, Hicks D, Xu B, Sigel JE, Bergfeld WF, Montgomery E, Fisher C, Hartke M, Tubbs R, Goldblum JR. Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma. 2004. Mod Pathol. 2005 May;18(5):705-9. doi: 10.1038/modpathol.3800349. PMID: 15578074.
  • Xu B, Bhattacharjee A, Roy B, Feldman GM, Cathcart MK. Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytes. J Biol Chem. 2004 Apr 16;279(16):15954-60. doi: 10.1074/jbc.M400413200. Epub 2004 Feb 2. PMID: 14757756.
  • Bey EA, Xu B, Bhattacharjee A, Oldfield CM, Zhao XX, Li Q, Subbulakshmi V, Feldman GM, Wientjes FB, Cathcart, MK. Protein Kinase Cδ Is Required for p47phox Phosphorylation and Translocation in Activated Human Monocytes. J Immunol. 2004 Nov 1;173(9):5730-5738. doi: 10.4049/jimmunol.173.9.5730.
  • Das M, Xu B, Lin L, Chakrabarti S, Shivaswamy V, Rote NS. Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. Placenta. 2004 May;25(5):396-407. doi: 10.1016/j.placenta.2003.11.004. PMID: 15081634.
  • Agrawai S, Podrez E, Xu B, Cathcart M, Stark GR, Chisoim, GM. Inhibition of stat1 activity inhibits foam cell formation in macrophages. Cardiovasc Pathol. 2004 May;13(3):93-94. doi: 10.1016/j.carpath.2004.03.277.
  • Xu B, Bhattacharjee A, Roy B, Xu HM, Anthony D, Frank DA, Feldman GM, Cathcart MK. Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3. Mol Cell Biol. 2003 Jun;23(11):3918-28. doi: 10.1128/mcb.23.11.3918-3928.2003. PMID: 12748293; PMCID: PMC155212.
  • Zhang YM, Xu B, Rote N, Peterson L, Amesse LS. Expression of homeobox gene transcripts in trophoblastic cells. Am J Obstet Gynecol. 2002 Jul;187(1):24-32. doi: 10.1067/mob.2002.122850. PMID: 12114884.
  • Roy B, Bhattacharjee A, Xu B, Ford D, Maizel AL, Cathcart MK. IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats. J Leukoc Biol. 2002 Sep;72(3):580-9. PMID: 12223527.
  • Lin L, Xu B, Rote NS. The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo. Placenta. 2000 Jan;21(1):73-8. doi: 10.1053/plac.1999.0443. PMID: 10692254.
  • Zhang YM, Xu B, Peterson L, Rote NS, Amesse L. Regulation of HOX A11 in trophoblastic cells. Fertility and Sterility. 2000 Sep;74(3):S195. doi: 10.1016/S0015-0282(00)01294-2.
  • Xu B, Lin L, Rote NS. Identification of a stress-induced protein during human trophoblast differentiation by differential display analysis. Biol Reprod. 1999 Sep;61(3):681-6. doi: 10.1095/biolreprod61.3.681. PMID: 10456845.
  • Lin L, Xu B, Rote NS. Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast. Placenta. 1999 Jan;20(1):109-18. doi: 10.1053/plac.1998.0337. PMID: 9950152.
  • Rote NS, Lin L, Xu B. The expression of ERV-3 mRNA in a choriocarcinoma model of trophoblastic differentiation. Placenta. 1998; 19(2):315-326. doi: 10.1016/S0143-4004(98)80051-9.
  • Wang L, Xu B, White RE, Lu L. Growth factor-mediated K+ channel activity associated with human myeloblastic ML-1 cell proliferation. Am J Physiol. 1997 Nov;273(5):C1657-65. doi: 10.1152/ajpcell.1997.273.5.C1657. PMID: 9374652.
  • Xu B, Wilson BA, Lu L. Induction of human myeloblastic ML-1 cell G1 arrest by suppression of K+ channel activity. Am J Physiol. 1996 Dec;271(6 Pt 1):C2037-44. doi: 10.1152/ajpcell.1996.271.6.C2037. PMID: 8997206.
  • Xu B, Lu L. Protein kinase A-regulated Cl- channel in ML-1 human hematopoietic myeloblasts. J Membr Biol. 1994 Oct;142(1):65-75. doi: 10.1007/bf00233384. PMID: 7707354.

Request an Appointment

Make an appointment by calling 1-800-ROSWELL (1-800-767-9355)

Make an Appointment