Bo Xu

Bo Xu

MD, PhD

Specializing In:

Oncologic surgical pathology with emphasis in genito-urologic tumors Thoracic pathology Head/neck pathology

Special Interests:

Histomorphological diagnosis, Classification and staging of urologic and male genital tumors, lung and mediastinal tumors, head & neck tumors Clinicopathologic correlation and translational research on above tumors

Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • Staff Physician
  • Associate Professor of Oncology
  • Department of Pathology & Laboratory Medicine

Background

Education and Training:

  • PhD - Wright State University Biomedical Science Ph.D. Program, Dayton, OH
  • MD - Nanjing Medical University Faculty of Medicine, Nanjing, China

Residency:

  • Department of Pathology, SUNY at Buffalo, Buffalo, NY
  • Department of Medicine, Section of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Fellowship:

  • Visiting Fellow, Section of Genitourinary Pathology, Indiana University School of Medicine, Indianapolis, IN
  • Fellow, Ontological Surgical Pathology, Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY
  • Post-doctoral Fellow, Howard Hughes Medical Institute Department of Microbiology & Immunology Vanderbilt University School of Medicine, Nashville, TN

Board Certification:

  • Anatomic Pathology, American Board of Pathology
  • Clinical Pathology, American Board of Pathology

Professional Memberships:

  • United States and Canadian Academy of Pathology
  • American Society of Clinical Pathologists
  • College of American Pathologists
  • Association of Molecular Pathology

Publications

  • Shen, H, Blijlevens, M, Yang, N, Frangou, C, Wilson, KE, Xu, B, Zhang, Y, Zhang, L, Morrison, CD, Shepherd, L, Hu, Q, Zhu, Q, Wang, J, Liu, S and Zhang, J. Sox-4 expression confers bladder cancer stem cell properties and predicts for poor patient outcome. 2015. Int. J. Biol. Sci. In Press
  • Sule, N, Xu, B, Zein, D, Szigeti, K, Kane, J, Cheney, RT. Radiation induced chondrosarcoma of the bladder, case report and review of literature. 2015. Anticancer. 35(5):2857-60.
  • Cheng, J, Ondracek, RP, Mehedint, D, Kasza, K, Xu, B, Gill, S, Azabdaftari G,Yao, S, Morrison, C, Mohler, J, Marshall, J,. Association of Fatty Acid Synthase Polymorphisms and Expression with Outcomes after Radical Prostatectomy. 2015. Prostate Cancer Prostatic Dis. 18(2):182-9.
  • Pokuri, VK, Xu, B, Neppalli, V, Czyzyk, J, Berenji, F, Holstein, SA, McCarthy, PL. Synchronous presentation of monoclonal gammopathy and Fabry nephropathy; diagnostic renal biopsy obviates initiation of myeloma therapy. 2015. Ann. Hematol. 94(6):1067-68.
  • Li, YW, Shen H, Yang, N, Guo, J, Xu, B, Bshara, W, Shepherd, L, Zhu, Q, Wang, J, Hu, Q, Liu, S, Morrison, CM, Sun, P and Zhang, J. Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis. 2015. Cell Cycle. 14(1):146-156.
  • Zhong, H, George, S, Kauffman, E, Guru, K, Azabdaftari, G and Xu, B. Clinicopathologic characterization of intradiverticular carcinoma of urinary bladder - a study of 22 cases from a single cancer center. 2014. Diagn Pathol. 9:222-228.
  • Vacchio, M, Attwood, K, Mechedint, D, Murekeyioni, Azabdaftari, G, Xu, B, Mohler, J and Kauffman E. Does prospectively assigned tertiary pattern 4 affect prognosis of Gleason grade 3+3=6 prostatectomy patients? 2014. J. Urol. 191(4):926-927
  • Nakanishi, Y, Xu, B and LeVea, C. Oral Floor and Gingival Metastasis of Cholangiocarcinoma: A Case Report and Review of the Literature. 2014. Case Reports in Pathology. Volume 2014, Article ID 712912, 3 pages. http://dx.doi.org/10.1155/2014/712912.
  • Zhong, H, Xu, B and Popiolek, DA. Growth Patterns of Placental and Paraovarian Adrenocortical Heterotopias Are Different. Case Reports in Pathology. Volume 2013, Article ID 205692, 6 pages. http://dx.doi.org/10.1155/2013/205692
  • Pokuri, V, Sule, S, Soofi, Y, Xu, B, Guru K and George, S. A Case of Unusual Mast Cell Response with Interstitial Cystitis-Like Symptoms to Neoadjuvant Chemotherapy for Muscle-Invasive Transitional Cell Carcinoma of the Bladder. J Natl Compr Canc Netw 2013;11:1459-1463.
  • Gao, C, D’Angelis, CD, Qiu, J and Xu, B. Hyalin globules in epithelial neoplasm of kidney (Review article). 2013. North Am J Med & Sci. 6 (1):41-43.
  • Liu, YG, Cheney, RT, Omilian, A, Morrison C and Xu, B. Expression of PAX2 and renal cell carcinoma antigen in mucoepidermoid carcinoma. 2012. North Am J Med & Sci. 5 (4):203-207.
  • Sinnott, M, Chen, F, Kanehira, K, Sule, N and Xu, B. Clear cell papillary renal cell carcinoma – A new emerging entity (Review article). 2012. North Am J Med & Sci. 5 (4):224-227.
  • Liu, YG, Xu, B and Chen F. Recent advances in renal cell carcinoma associated with Xp11.2 translocations/TFE gene fusions (Review article). 2012. North Am J Med & Sci. 5 (1):43-47.
  • Hsi, LC, Kundu, S, Palomo J., Xu, B, Ficco, R, Vogelbaum, MA and Cathcart, MK. Silencing IL-13Ra2 promotes glioblastoma cell death via endogenous signaling. 2011. Mol Cancer Ther. 10(7):1149-60.
  • Xu, B, Tan, DF, Thong, T and Khoury, T. Expression of thyroid transcription factor-1 in Colorectal Carcinoma. 2010. Appl Immunohistochem Mol Morphol. 18(3):244-249.
  • Xu, B, Lin, L, and Chen, F. Desmoplastic Trichoepithelioma with Milia-like Structure. 2009. North Am J Med & Sci. 2 (1):22-23.
  • Xu, B, Balos, L, Goodloe, S., Krabill, K, Chmiel, R and Chen, F. Immunohistochemical studies of cell cycle-associated proteins in mandible central giant cell tumor. 2009. North Am J Med & Sci. 2 (2):10-12.
  • Bhattacharjee, A, Xu, B, Frank, DA, Feldman, GM and Cathcart, MK. Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3. 2006. J Immunol. 177:3771-81.
  • Skacel, M., Siva, A., Xu, B and Tubbs, RR. From array to array: Confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays. 2006. J Mol Histol. 38 (2):135-140.
  • Xu, B, Tubbs, RR and Kottke-Marchant, K. Molecular genetic testing of polymorphisms associated with venous thrombosis: A review of molecular technologies (Review article). 2005. Diagn Mol Pathol. 14 (4):193-202.
  • Zhao, X, Xu, B, Bhattacharjee, A, Horton, HM, Wientjes, FB, Cathcart, MK. Protein kinase C-delta regulates p67phox phosphorylation in human monocytes. 2005. J Leukoc Biol. 77:414-420.
  • Lin, L, Hicks, D, Xu, B, Sigel, JE, Bergfeld, WF, Montgomery, E, Fisher, C, Hartke, M, Tubbs, RR, Goldblum. JR. Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma. 2004. Modern Pathol. 18:705-709.
  • Xu, B, Bhattacharjee, A, Roy, B, Feldman, GM, Cathcart, MK, Role of protein kinase C isoforms in the regulation of IL-13-induced 15-lipoxygenase gene. 2004. J Bio Chem. 279 (16):15954-15960.
  • Bey, EA, Xu, B, Horton, CM, Bhattacharjee, A, Zhao, XX, Cathcart, MK. Protein kinase C-delta isoform mediates phosphorylation and membrane translocation of p47phox of NADPH oxidase in human monocytes. 2004. J Immunol. 173:5730-5738.
  • Das, M., Xu, B., Lin, L, Chakrabarti, S, Shivaswamy, V, Rote, NS. Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. 2004. Placenta. 25(5):396-407.
  • Agrawai, S, Podrez, E, Xu, B, Cathcart, M, Stark, GR and Chisoim, GM. Inhibition of stat1 activity inhibits foam cell formation in macrophages. 2004. Cardiovasc Pothol. 13(3):93-94.
  • Xu, B, Bhattacharjee, A, Roy B, Xu, HM, Anthony D, Frank, DA, Feldman, GM and Cathcart, MK. Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated Serine 727 phosphorylation of Stat1 and Stat3. 2003. Mol Cell Biol. 23:3918-3928.
  • Zhang, YM, Xu, B, Rote, NS, Peterson, L, and Amesse, L. Expression and function of HOX genes in human trophoblastic cells. 2002. Am J Obstet Gynecol. 187:24-32.
  • Roy, B, Bhattacharjee, A, Xu, B, Ford, D, Maizel, AL and Cathcart, MK. IL-13 signal transduction in human monocytes: Phosphorylation of receptor components, association with Jaks and phosphorylation of Stats. 2002. J Leukoc Biol. 72:580-589.
  • Lin, L, Xu, B, and Rote, NS. The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in human placental trophoblast model, BeWo. 2000. Placenta. 21:73-78.
  • Zhang YM, Xu, B, Peterson, L, Rote, NS and Amesse, L. Regulation of HOX A11 in trophoblastic cells. 2000. Fertility and Sterility. 74(3). DOI: 10.1016/S0015-0282(00)01294-2
  • Xu, B, Lin, L. and Rote, NS. Identification of a novel stress-induced protein involved in human choriocarcinoma BeWo cell differentiation by differential display analysis. 1999. Biol Reprod. 61:681-686.
  • Lin, L, Xu, B, and Rote, NS. Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast. 1999. Placenta. 20: 109-118.
  • Rote, N.S, Lin, L and Xu, B. The expression of ERV 3 mRNA in a choriocarcinoma model of trophoblastic differentiation. In: Carter, A. and H. Thiede (ed.), New Directions in Placental Research. University of Rochester Press, Rochester, NY, 1998. Trophoblast Research. 12: 315-326.
  • Wang, L, Xu, B, White, RE and Lu, L. Growth factor-mediated K+ channel activity associated with human myeloblastic ML-1 cell proliferation. 1997. Am J Physiol. 273: C1657-1665
  • Xu, B, Wilson, B, Lu, L. Induction of human myeloblastic ML-1 cell G1 arrest by suppression of K+ channel activity. 1996. Am J Physiol. 271: C2037-C2044.
  • Xu, B, Lu, L. Protein kinase A-regulated Cl- channel in ML-1 human hematopoietic myeloblasts. 1994. J Membrane Biol. 142: 65-75.