Dr. William J. Magner joined the faculty of Roswell Park Comprehensive Cancer Center in 1999 as a Research Scientist in the Department of Immunology, and was appointed Affiliate Member in 2000.
Dr. Magner earned his doctoral degree in Biochemistry, with a minor in Immunology, from Case Western Reserve University, Cleveland, OH, in 1994. Between 1994 and 1999, he completed postdoctoral fellowship training at the National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD. Dr. Magner also is Instructor, Immunology Program, Roswell Park Graduate Division, University at Buffalo.
Dr. Magner’s research interests, in collaboration with Dr. Tomasi, include the role of miRNA in regulating immune gene expression; the effect of histone acetylation on gene expression; effect of trichostatin A treatment on expression of genes of immunological interest in various tumors; use of targeted therapeutics which activate immune gene expression and enhance tumor immunogenicity; definition of the mechanisms of action of trichostatin A.
Dr. Magner has authored or co-authored a number of journal publications and abstracts.
Tomasi TB, Magner WJ, Wiesen JL, Oshlag JZ, Cao F, Pontikos AN, Gregorie CJ. MHC class II regulation by epigenetic agents and microRNAs. Immunologic research 2010; 46(1-3):45-58
Asirvatham AJ, Magner WJ, Tomasi TB. miRNA regulation of cytokine genes.Cytokine 2009; 45(2):58-69
Gregorie CJ, Wiesen JL, Magner WJ, Lin AW, Tomasi TB. Restoration of immune response gene induction in trophoblast tumor cells associated with cellular senescence. Journal of reproductive immunology 2009; 81(1):25-33
Asirvatham AJ, Gregorie CJ, Hu Z, Magner WJ, Tomasi TB. MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components.Molecular immunology 2008; 45(7):1995-2006
Khan AN, Magner WJ, Tomasi TB. An epigenetic vaccine model active in the prevention and treatment of melanoma. Journal of translational medicine 2007;5:64