Dr. Wiam Bshara Wiam Bshara, MD

Wiam Bshara

MD
Pathology

Specializing In:

Breast cancer Prostate cancer Gynecologic cancers

Special Interests:

Basic and translational research in gynecologic, breast and genitourinary cancers

About Wiam Bshara

Biography:

Dr. Bshara is responsible for assisting Dr. Carl Morrison in directing the day-to-day operation of all aspects of the Roswell Park Pathology Resource Network. As a pathologist, Dr. Bshara works very closely with the faculty and staff in Tissue Procurement and leads the overall organization of this vital resource. In addition, Dr. Bshara oversees the Tissue Microarray Laboratory as well as the Image Scanning and Analysis Laboratory.

Positions

Roswell Park Comprehensive Cancer Center
  • Assistant Director, Pathology Resource Network

Background

Education and Training:

  • 1989-1995 - Tishreen University School of Medicine, Lattakia, Syria

Residency:

  • 2002-2003 - State University of New York at Buffalo, Buffalo, NY
  • 2000-2002 - Allegheny General Hospital, Pittsburgh, PA
  • 1996-1998 - Damascus University, Damascus, Syria

Fellowship:

  • 2005-2007 - Roswell Park Cancer Institute, Buffalo, NY

Publications

  • Francis J, Smiley S, Battiwalla M, Wetzler M, Barcos M, Bshara W, Paplham P, Brown K, Syta M, Lamonica D, Loud P, McCarthy P. Detection of extra-medullary relapse of acute lymphoblastic leukemia by radiographic imaging following allogeneic hematopoietic SCT. Bone Marrow Transplant. 2009 Dec;44(12):827-8. doi: 10.1038/bmt.2009.183. Epub 2009 Jul 27. PMID: 19633688.
  • Khoury T, Tan D, Bshara W. HER2 testing: The equivocal category by immunohistochemistry should be expanded to include cases with any 2+ staining and cases with 3+ staining in < 70% instead of < 30% of tumor cells to have high concordance rate with FISH. Laboratory Investigation. 2011;91(Suppl. 1):192
  • Riddell JR, Bshara W, Moser MT, Spernyak JA, Foster BA, Gollnick SO. Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature. Cancer Res. 2011 Mar 1;71(5):1637-46. doi: 10.1158/0008-5472.CAN-10-3674. Epub 2011 Feb 22. PMID: 21343392; PMCID: PMC3076642.
  • Kurenova E, Liau J, Seshadri M, Bshara W, Cance W. The novel FAK inhibitor CFAK-C4 targeted to the binding site of VEGFR-3 inhibits pancreatic cancer proliferation and interferes with tumor vasculogenesis. Annals of Oncology. 2011; 22(Suppl. 5):v57-v58
  • Mhawech-Fauceglia P, Herrmann F, Bshara W, Zhang S, Penetrante R, Lele S, Odunsi K, Rodabaugh K. Intraobserver and interobserver variability in distinguishing between endocervical and endometrial adenocarcinoma on problematic cases of cervical curettings. Int J Gynecol Pathol. 2008 Jul;27(3):431-6. doi: 10.1097/PGP.0b013e3181601792. PMID: 18580323.
  • Pande R, Sunga A, Levea C, Wilding GE, Bshara W, Reid M, Fakih MG. Significance of signet-ring cells in patients with colorectal cancer. Dis Colon Rectum. 2008 Jan;51(1):50-5. Epub 2007 Nov 21. doi: 10.1007/s10350-007-9073-7. PMID: 18030531.
  • Mhawech-Fauceglia P, Herrmann FR, Bshara W, Odunsi K, Terracciano L, Sauter G, Cheney RT, Groth J, Penetrante R, Mhawech-Fauceglia P. Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody. J Clin Pathol. 2007 Jun;60(6):694-700. doi: 10.1136/jcp.2006.039230. Epub 2006 Aug 17. PMID: 16917000; PMCID: PMC1955051.
  • Mhawech-Fauceglia P, Ramzy P, Bshara W, Sait S, Rigual N. Synovial sarcoma of the larynx in a 79-year-old woman, confirmed by karyotyping and fluorescence in situ hybridization analysis. Ann Diagn Pathol. 2007 Jun;11(3):223-7. doi: 10.1016/j.anndiagpath.2006.02.007. PMID: 17498599.
  • Mhawech-Fauceglia P, Smiraglia DJ, Bshara W, Andrews C, Schwaller J, South S, Higgs D, Lele S, Herrmann F, Odunsi K. Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):571-7. doi: 10.1158/1055-9965.EPI-07-0511. PMID: 18349274.
  • Akakura S, Bouchard R, Bshara W, Morrison C, Gelman IH. Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlate with FAK upregulation. Int J Cancer. 2011 Oct 15;129(8):2025-31. doi: 10.1002/ijc.25828. Epub 2011 Apr 1. PMID: 21128249; PMCID: PMC3107938.
  • Deeb KK, Luo W, Karpf AR, Omilian AR, Bshara W, Tian L, Tangrea MA, Morrison CD, Johnson CS, Trump DL. Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate. Epigenetics. 2011 Aug;6(8):994-1000. doi: 10.4161/epi.6.8.16536. Epub 2011 Aug 1. PMID: 21725204; PMCID: PMC3219083.
  • Khoury T, Kulkarni S, Morrison C, Bshara W, Zakharia Y, Edge S. HER2 Testing: How to Reach a High Concordance Rate Between Immunohistochemistry and Fluorescence In Situ Hybridization. Appl Immunohistochem Mol Morphol. 2011 Oct;19(5):424-30. doi: 10.1097/PAI.0b013e31820b62be. PMID: 21386703.
  • Chan A, Bshara W, Odunsi K, Pejovic T, Mhawech-Fauceglia P. Clinico-pathologic features of female genital tract neuroendocrine carcinoma: A series study of 25 cases from two institutes. Laboratory Investigation. 2008; 88(Suppl. 1):199A (Abstract #912).
  • Mhawech-Fauceglia P, Bshara W, South S, Andrews C, Lele S, Odunsi K. PSMA mRNA and protein expression as potential prognostic markers in endometrial adenocarcinoma. American Association for Cancer Research. 2007 May;67(9):399.
  • Ademuyiwa FO, Bshara W, Attwood K, Edge SB, Ambrosone CB, Morrison CD, Ritter G, Miliotto A, Gnjatic S, Odunsi K. Immunogenicity of NY-ESO-1 cancer testis antigen in triple-negative breast cancer. Journal of Clinical Oncology. 2012; 30(15 Suppl.):e11563-e11563
  • Yang N, Morrison CD, Liu P, Miecznikowski J, Bshara W, Han S, Zhu Q, Omilian AR, Li X, Zhang J. TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin. Cell Cycle. 2012 Aug 1;11(15):2922-30. doi: 10.4161/cc.21386. Epub 2012 Aug 1. PMID: 22825057; PMCID: PMC3419062.
  • Ademuyiwa FO, Bshara W, Attwood K, Morrison C, Edge SB, Karpf AR, James SA, Ambrosone CB, O'Connor TL, Levine EG, Miliotto A, Ritter E, Ritter G, Gnjatic S, Odunsi K. NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer. PLoS One. 2012;7(6):e38783. doi: 10.1371/journal.pone.0038783. Epub 2012 Jun 28. Erratum in: PLoS One.2012;7(8). doi:10.1371/annotation/5cdf6105-2a52-497a-86b3-db8f4a4e439c. Karpf, Adam R [added]; James, Smith A [added]. PMID: 22761704; PMCID: PMC3386262.

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